AN IDENTIFICATION OF RODENT AND HUMAN NEURAL STEM CELLS: A SYSTEMATIC REVIEW

AN IDENTIFICATION OF RODENT AND HUMAN NEURAL STEM CELLS: A SYSTEMATIC REVIEW | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 31 January 2025 V1 Latest version Share on AN IDENTIFICATION OF RODENT AND HUMAN NEURAL STEM CELLS: A SYSTEMATIC REVIEW Author : Nurul Hidayah Authors Info & Affiliations https://doi.org/10.22541/au.173832301.17199707/v1 196 views 147 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Neural stem cells (NSCs) are primitive cells that are multipotent, undifferentiated, and self-renewable. The discovery of NSCs challenges the long-held belief that neurons, once lost or damaged, cannot be replaced. However, there is a lack of studies identifying NSCs in rodents and humans. This study aims to identify and analyze NSCs, specifically their protein markers and locations in rodents and humans. The study employed a systematic review, conducted according to the PRISMA guidelines. Data were retrieved from databases such as PubMed, Science Direct, and Nature. A total 47 studies were analyzed, highlighting the positive staining of proteins such as Nestin, GFAP, Olig2, DCX, SOX2, SOX9, Ki-67, β-tubulin III, and S100β. These proteins were predominantly located in the inner part of the subventricular zone (SVZ) or subependymal zone (SEZ) along the lateral ventricle walls, as well as the subgranular zone (SGZ) of the hippocampus. In humans, NSC can be detected by analyzing GFAP-positive areas in the SVZ and the hippocampus region of the human brain. NSC-positive markers detected in rodents included Nestin and GFAP, which align with findings in the human brain. Furthermore, the location of NSCs in both rodents and humans predominantly shows positive results in the SVZ along the lateral ventricle walls and SGZ of the dentate gyrus in the hippocampus. This comprehensive analysis provides a foundation for future research and clinical applications. Supplementary Material File (manuscript.pdf) Download 587.42 KB File (table.pdf) Download 114.72 KB Information & Authors Information Version history V1 Version 1 31 January 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords human brain neural stem cells neurogenesis protein markers rodents Authors Affiliations Nurul Hidayah Universitas Indonesia View all articles by this author Metrics & Citations Metrics Article Usage 196 views 147 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Nurul Hidayah. AN IDENTIFICATION OF RODENT AND HUMAN NEURAL STEM CELLS: A SYSTEMATIC REVIEW. Authorea . 31 January 2025. DOI: https://doi.org/10.22541/au.173832301.17199707/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. 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