The Effect of Prostaglandin Synthetase Inhibitors on Human Preovulatory Follicular Fluid Prostaglandin, Thromboxane, and Leukotriene Concentrations*

A.R. Priddy, S.R. Killick, Max Elstein, Julie Morris, Mark Sullivan, Lata Patel, Murdo G. Elder
In: The Journal of Clinical Endocrinology & Metabolism · 1990 · vol. 71(1) , pp. 235–242 · doi:10.1210/jcem-71-1-235 · PMID:2115045 · W1991689324
article OA: closed CC0 ⤵ 2 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study found that indomethacin and bromfenac significantly reduced prostaglandin E2 and PGF2 alpha levels in human preovulatory follicular fluid, with bromfenac also decreasing leukotriene B4.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

This study evaluates the eicosanoid concentration in luteinized unruptured follicles (LUFs) on the ovaries of patients who had been treated with inhibitors of prostaglandin synthetase. Indomethacin, bromfenac, or azapropazone (or a placebo) was administered orally to 41 women during the periovulatory period. Follicular development was monitored by serial ultrasound examinations, and the onset of ovulation was regulated by an injection of hCG. Follicular fluid was aspirated during sterilization by minilaparotomy, which was performed just before the expected time of ovulation. Prostaglandin E2 and PGF2 alpha levels in the fluid were significantly reduced by indomethacin and bromfenac compared to those after placebo treatment. Bromfenac also reduced the follicular fluid leukotriene B4 level. Therefore, the development of luteinized unruptured follicles after treatment with nonsteroidal antiinflammatory drugs appears to be associated with a significant decrease in the synthesis of ovarian eicosanoids.

My notes (saved in your browser only)

Citation neighborhood (sparse)

Too few in-corpus citations on either side for a chart; here are the lists.

Cites (2)

Cited by (2)

References (14)

Cited by (2)

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
License: CC0 · commercial use OK