Unilateral Mandible Hyperplasia : a Case Series and Our Individualized Protocol

Unilateral Mandible Hyperplasia : a Case Series and Our Individualized Protocol | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Case Report Unilateral Mandible Hyperplasia : a Case Series and Our Individualized Protocol Qin Yang, Wu Zhongxing This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-8174792/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Background :: Unilateral mandibular hyperplasia (UMH) often leads to facial asymmetry and occlusal disturbances, with no unified diagnostic or therapeutic guidelines currently available.Therefore, this study aims to establish principles for developing individualized treatment protocol and illustrate some refinements in surgical approach by presenting a series of UMH cases. Case Presentation :: A retrospective analysis was conducted on 8 adult UMH patients (aged 19-39). All patients presented with facial asymmetry and occlusal deviation. Treatment involved three protocols incorporating techniques such as modified intraoral vertical ramus osteotomy(IVRO) with synchronous condylectomy and modified sagittal split ramus osteotomy(SSRO) enabling single-stage nerve dissection. Postoperatively, patients achieved restored facial symmetry, stable occlusion, functional improvement, and no recurrence. Conclusion :: Despite limitations including a small sample size and lack of pediatric cases, this study establishes a systematic framework based on the "surgery-first" principle for adult UMH. Integrating digital technology with refined surgical techniques can effectively achieve facial and functional reconstruction. Unilateral mandibular hyperplasia individualized protocol SPECT surgery-first intraoral vertical ramus osteotomy sagittal split ramus osteotomy Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-8174792","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Case Report","associatedPublications":[],"authors":[{"id":557200019,"identity":"ddcbef0c-7869-4e99-a86f-66b9d9c68543","order_by":0,"name":"Qin Yang","email":"","orcid":"","institution":"Wuhan University","correspondingAuthor":false,"prefix":"","firstName":"Qin","middleName":"","lastName":"Yang","suffix":""},{"id":557200020,"identity":"f100bcab-dc24-475e-bf0b-ced650636699","order_by":1,"name":"Wu 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Protocol","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Unilateral mandibular hyperplasia, individualized protocol, SPECT, surgery-first, intraoral vertical ramus osteotomy, sagittal split ramus osteotomy","lastPublishedDoi":"10.21203/rs.3.rs-8174792/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-8174792/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cstrong\u003eBackground\u003c/strong\u003e:: Unilateral mandibular hyperplasia (UMH) often leads to facial asymmetry and occlusal disturbances, with no unified diagnostic or therapeutic guidelines currently available.Therefore, this study aims to establish principles for developing individualized treatment protocol and illustrate some refinements in surgical approach by presenting a series of UMH cases.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eCase Presentation\u003c/strong\u003e:: A retrospective analysis was conducted on 8 adult UMH patients (aged 19-39). All patients presented with facial asymmetry and occlusal deviation. Treatment involved three protocols incorporating techniques such as modified intraoral vertical ramus osteotomy(IVRO) with synchronous condylectomy and modified sagittal split ramus osteotomy(SSRO) enabling single-stage nerve dissection. Postoperatively, patients achieved restored facial symmetry, stable occlusion, functional improvement, and no recurrence.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConclusion\u003c/strong\u003e:: Despite limitations including a small sample size and lack of pediatric cases, this study establishes a systematic framework based on the \"surgery-first\" principle for adult UMH. Integrating digital technology with refined surgical techniques can effectively achieve facial and functional reconstruction.\u003c/p\u003e","manuscriptTitle":"Unilateral Mandible Hyperplasia : a Case Series and Our Individualized Protocol","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2025-12-09 12:34:20","doi":"10.21203/rs.3.rs-8174792/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"f69cad69-a69f-401b-91c6-ea6e5b1bd86a","owner":[],"postedDate":"December 9th, 2025","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[],"tags":[],"updatedAt":"2026-02-11T11:42:07+00:00","versionOfRecord":[],"versionCreatedAt":"2025-12-09 12:34:20","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-8174792","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-8174792","identity":"rs-8174792","version":["v1"]},"buildId":"8U1c8b4HqxoKbykW_rLl7","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}