Analysis of the correlation between the expression of non-classical E2F transcription factor 8 (E2F8) in pan-cancer and prognosis and immune infiltration

Despite emerging cell-or animal-based evidence supporting a relationship between E2F8 and cancer, a pan-cancer analysis has not been performed. By integrating various databases containing transcriptome, prognosis, and immune-related data, such as gene expression matrices, this study utilized the ESTIMATE algorithms and R program package to comprehensively investigate the pathogenic implications of E2F8 in diverse tumors. Multiple aspects were explored, including gene expression, survival analysis, gene variation, immune infiltration, and co-expression pathway analysis. The results of the analysis demonstrated that the expression of E2F8 differed significantly in 23 types of tumors as compared to normal tissues, and was also linked to unfavorable prognosis in some cancer patients. Additionally, the E2F8 gene showed a considerable frequency of mutation, particularly at the P56L/S site. Furthermore, in several tumors, E2F8 was found to be significantly correlated with immune scores and the infiltration of immune cells in the tumor microenvironment.