The effects and safety of hormone replacement therapy on women with endometriosis and underwent hysterectomy and bilateral salpingo-ophorectomy

Objective:To estimate the recurrence of endometriosis and clinical effects after administration of hormone replacement therapy(HRT) among women who have had endometriosis and underwent hysterectomy and bilateral salpingo-ophorectomy(BSO) and had the symptoms of perimenopause.Methods:42 patients were divided into two groups randomly.20 received livial 1.25 mg every day orally,and 22 received Premarin 0.3 mg everyday orally.Periodical clinical examination and vaginal ultrasound were performed,and the level of E_2/FSH and the symptoms of endometriosis were recorded.Kupperman score were observed before and after treatment between two groups.Results:After treatment,there was no recurrence in two groups.The symptoms of perimenopause were significantly improved in both groups(P0.01),and the level of E_2 significantly increased in two groups(P0.01).The group who received premarin had higher level of E_2 than the group who received livial(P0.05).Conclusion:The low dose premarin and livial can relieve climacteric symptoms safely on women who have had endometriosis and underwent hysterectomy and bilateral salpingo-ophorectomy.