Policresulen gel in treatment of cervical erosion:a random,positive drug parallel controlled,multicenter clinical study

AIM To evaluate the effectiveness and safety of policresulen gel in treatment of cervical erosion.METHODS All the chosen patients with cercial erosion were randomly divided into trial group(policresulen gel) and control group(policresulen vaginal suppository).One piece/suppository was used every two nights for total 6 times,starting from 3-7 days after the end of menstruation.The patients were followed up and the change of erosion type,symptom and adverse events were recorded.RESULTS Totally 251 patients were included,126 in the trial group and 125 in the control group.For Per-protocol Set(PPS),the effectiveness was 83.0%in the trial group(n = 106) and 82.1%in the control group(n = 112),showing no statistical difference(P 0.05);there was non-inferiority in the trial group compared with the control group with non-inferior standard setting 0.1.For Safety Set(SS),there were 15 adverse events in the trial group(12.7%,n = 118) and 10 in control group(8.3%,n = 120),with no statistical difference(P 0.05).CONCLUSION Policresulen gel can be used effectively and safely in treatment of cercial erosion.