Some clotting factors in plasma during danazol therapy: free and total protein S, but not C4b-binding protein, are elevated by danazol therapy.

H Thorisdottir; Hilda Thorisdottir; Thorisdottir H; J A Evans; Judith A. Evans; Evans Ja; Schwartz HJ; H J Schwartz; Howard J. Schwartz; Comp P; P C Comp; P Comp; J Haluschak; Haluschak J; John J. Haluschak; Ratnoff OD; O D Ratnoff

Some clotting factors in plasma during danazol therapy: free and total protein S, but not C4b-binding protein, are elevated by danazol therapy.

H Thorisdottir, Hilda Thorisdottir, Thorisdottir H, J A Evans, Judith A. Evans, Evans Ja, Schwartz HJ, H J Schwartz, Howard J. Schwartz, Comp P, P C Comp, P Comp, J Haluschak, Haluschak J, John J. Haluschak, Ratnoff OD, O D Ratnoff

The Journal of laboratory and clinical medicine · 1992 · vol. 119(6) , pp. 698–701 · PMID:1534346 · W2410319074

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Danazol therapy increased plasma concentrations of heparin cofactor II, Hageman factor, protein C, and both free and total protein S, with total protein S remaining elevated after therapy cessation.

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Abstract

Anabolic steroids are known to increase the plasma concentrations of certain plasma proteins. In four patients given treatment with danazol, an attenuated androgen, the concentrations of heparin cofactor II, Hageman factor (factor XII), protein C, and both free and total protein S increased significantly when tested 39 to 103 days after the start of therapy. The titers of these proteins in samples obtained 21 days to 5 years after therapy was discontinued were similar to those before treatment, except for total protein S, the titer of which remained elevated. No significant changes in the titers of C4b binding protein or plasma plasmin inhibitory activity were found.

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Condition tags

endometriosis

MeSH descriptors

alpha 1-Antitrypsin Deficiency Blood Coagulation Factors Carrier Proteins Complement C4b Complement Inactivator Proteins Danazol Endometriosis Glycoproteins Adult Blood Coagulation Factors Carrier Proteins Complement C4b Danazol Endometriosis Endometriosis Female Glycoproteins Humans Male Protein S

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