⚙
AI-generated deep summary
by qwen3.7-flash, 2026-09-09
· read from full text
ⓘ
The provided text does not contain a scientific paper or research data regarding lesion dynamics in endometriosis. Instead, it displays a security challenge page generated by Anubis, a bot protection system that uses Proof-of-Work schemes to prevent automated scraping. The message explains technical requirements for accessing the site, such as enabling modern JavaScript features and disabling specific browser plugins like JShelter. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.
Abstract
In the present study two experimental animal models for endometriosis were used to characterize the dynamics of endometriotic lesions in the peritoneal cavity. The effect of 17ß-estradiol (E2) on mouse endometriotic lesions was analyzed using a syngeneic transplantation mouse model of endometriosis and two strains of ova-riectomized mice. Interestingly, at days 14 and 28 post transplantation, higher le-sion area in E2 treated animals was observed in comparison to vehicle treated ani-mals. This difference in area was not due to changes in cellular proliferation. De-tailed cell composition and apoptosis analysis revealed sex hormone dependent regulation of immune and non-immune cells within the lesions. Additionally, using a novel syngeneic transplantation luminescence mouse model demonstrated decrease in the concentration of cells from the originally transplanted tissue in the vehicle treated animals. Consequently, we proposed that apoptosis in resident lesion im-mune cells plus reduction in inflammation, and not proliferation or infiltration of host peritoneal cells, was responsible for the decrease in lesion area seen in estro-gen depleted animals. Macroscopic appearance and kinetic of endometriotic lesions was analyzed retro-spectively in a non-human primate (baboon) model of endometriosis with the goal of providing a better understanding of lesion dynamics over a 15 month period. The lesions changed their morphology from red to white over time. Different lesion types underwent metamorphosis at different rates. Surgical excision/ablation of ba-boon endometriotic lesions resulted in a high incidence of recurrence. Spontaneous endometriosis developed in control baboons in the absence of deposited autologous menstrual endometrium suggesting that repetitive surgical procedures alone can induce the spontaneous evolution of the chronic disease. In conclusion, using experimental endometriosis in two animal species the dynamic nature of edometriotic lesions as well as dependence on time and hormonal supply was demonstrated. Additional studies on the role of E2 in modulation of immune cell-facilitated inflammation and changes in morphological appearance may help further the understanding of lesion growth, effects of the lesions on symptoms, and the prognosis of the disease.
Full text
1,068 characters
· extracted from
oa-html
· click to expand
Making sure you're not a bot!
Loading...
You are seeing this because the administrator of this website has set up Anubis to protect the server against the scourge of AI companies aggressively scraping websites. This can and does cause downtime for the websites, which makes their resources inaccessible for everyone.
Anubis is a compromise. Anubis uses a Proof-of-Work scheme in the vein of Hashcash, a proposed proof-of-work scheme for reducing email spam. The idea is that at individual scales the additional load is ignorable, but at mass scraper levels it adds up and makes scraping much more expensive.
Ultimately, this is a placeholder solution so that more time can be spent on fingerprinting and identifying headless browsers (EG: via how they do font rendering) so that the challenge proof of work page doesn't need to be presented to users that are much more likely to be legitimate.
Please note that Anubis requires the use of modern JavaScript features that plugins like JShelter will disable. Please disable JShelter or other such plugins for this domain.
Text is read by the "Ask this paper" AI Q&A widget below.
Extraction quality varies by source — PMC NXML preserves structure
cleanly, OA-HTML may include some navigation residue, and OA-PDF can
have broken hyphenation. The publisher copy
(via DOI)
is the canonical version.