Fibrin-Associated Large B-Cell Lymphoma: First Case Report Within A Cerebral Artery Aneurysm And Literature Review

Fibrin-Associated Large B-Cell Lymphoma: First Case Report Within A Cerebral Artery Aneurysm And Literature Review | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Case report Fibrin-Associated Large B-Cell Lymphoma: First Case Report Within A Cerebral Artery Aneurysm And Literature Review Magda Zanelli, Maurizio Zizzo, Marco Montanaro, Vito Gomes, Giovanni Martino, and 4 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.2.12131/v3 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 13 Sep, 2019 Read the published version in BMC Cancer → Version 3 posted 4 You are reading this latest preprint version Show more versions Abstract Background: Fibrin-associated diffuse large B-cell lymphoma (FA-DLBCL) is a rare Epstein-Barr virus (EBV) positive lymphoproliferative disorder included in the current World Health Organization (WHO) classification. It arises within fibrinous material in the context of hematomas, pseudocysts, cardiac myxoma or in relation with prosthetic devices. In these clinical settings the diagnosis requires an high index of suspicion, because it does not form a mass itself, being composed of small foci of neoplastic cells. Despite overlapping features with diffuse large B-cell lymphoma associated with chronic inflammation, it deserves a separate classification, being not mass-forming and often following an indolent course. Case presentation: A 64-year-old immunocompetent woman required medical care for cerebral hemorrhage. Computed Tomography (CT) angiography identified an aneurysm in the left middle cerebral artery. A FA-DLBCL was incidentally identified within thrombotic material in the context of the arterial aneurysm. After surgical removal, it followed a benign course with no further treatment. Conclusions: The current case represents the first report of FA-DLBCL identified in a cerebral artery aneurysm, expanding the clinicopathologic spectrum of this rare entity. A complete literature review is additionally made. Oncology Fibrin B-cell Lymphoma Epstein-Barr virus Figures Figure 1 Figure 2 Figure 3 Introduction In the current WHO classification, diffuse large B-cell lymphoma associated with chronic inflammation (DLBCL-CI) is defined as an EBV-driven neoplasm, occurring in longstanding chronic inflammation in restricted spaces [1]. The prototype is pyothorax-associated lymphoma (PAL) arising in patients with a long history of pyothorax, following artificial pneumothorax as treatment for tuberculosis [1]. Recently, another EBV-related entity has been included among DLBCL-CI, but renamed fibrin-associated diffuse large B-cell lymphoma (FA-DLBCL) because it develops within fibrinous material [1]. It has been reported in association with pseudocysts, cardiac myxoma, valve prosthesis, fibrin thrombus, synthetic tube graft, hydrocele, metallic implants, and chronic subdural hematoma [1-25]. Differently from PAL, it does not form masses, being composed of rare neoplastic cells and it represents often an incidental finding [1]. Whereas PAL follows an aggressive course, the majority of FA-DLBCL behave favorably and may not require therapies other than surgery. Rare cases with persistent or localized recurrent disease have been described [9]. Only one case with a poor outcome has been reported so far [24]. We present the first report of FA-DLBCL incidentally disclosed in a cerebral artery aneurysm, widening the clinicopathological spectrum of this rare entity. Case presentation A 64-year-old immunocompetent woman was referred to hospital for cerebral hemorrhage in left temporal-parietal region. CT angiography detected an aneurysm in the distal segment of left middle cerebral artery. Tiny fragments of brain tissue together with partially organized thrombus were surgically removed. Histologically, it was identified an artery, with an interrupted wall, occluded by thrombotic material (Fig. 1). Small foci of large atypical lymphoid cells (Fig. 1, inset ; Fig. 2) were disclosed within thrombus. The cells were positive for PAX5 (Fig. 2, inset left ), CD30 and MUM1 (Fig. 2, inset right ) with partial expression of CD79α and CD20. The proliferative index (Fig. 3 A) was high (Ki67 about 90%). The cells expressed LMP-1 and were diffusely positive for EBV by in situ hybridization for EBV-encoded RNA (EBER) (Fig. 3, B). Clonal immunoglobulin heavy chain (IGH) rearrangement was detected. A fibrin-associated diffuse large B-cell lymphoma was diagnosed. Staging procedures (CT scan and bone marrow biopsy) were negative. Three months later, CT scan showed an almost complete hemorrhage resorption. No further treatment was given. The patient is alive, free of disease at 8 months from diagnosis. Discussion and Conclusions FA-DLBCL is a rare EBV-associated B-cell lymphoma included in the current WHO classification, in the chapter of DLBCL-CI [1]. Differently from DLBCL-CI, it is not mass-forming and therefore disclosed incidentally on histological evaluation of surgical specimens removed for other diseases [1]. 47 cases, including our, have been reported so far [1-25]. Clinicopathological data are summarized in Table 1. It shows male predominance with a wide age range. No ethnic differences have been apparently identified so far [9]. All cases, except 2 [9], occurred in immunocompetent individuals, presenting with different symptoms, depending on the underlying conditions in which FA-DLBCL occurred. Cardiac myxoma represents one of the most frequent site of occurrence with 14 cases identified, whereas only occasional cases arose in atrial thrombi and within mixomatous valve degeneration. Some cases have been identified in association with prosthetic devices such as endovascular graft, cardiac valve prosthesis and metallic implant. Time from placement of devices to lymphoma diagnosis is extremely variable, ranging from 1 to more than 20 years. A rather frequent site of presentation is represented by pseudocysts, with a total of 10 cases, in different organs (adrenal gland, spleen, kidney, retroperitoneum, testis). Single descriptions at unusual sites as within testicular hydrocele, ovarian teratoma and testicular hematoma are also reported. The intracranial location appears to be rare, with only 4 cases within chronic subdural hematomas 9,22,23,24, and 1 within an arachnoid cyst 25 . Our case represents the first report in a patient with a brain hemorrhage and incidentally identified within thrombotic material in a cerebral artery aneurysm. Notably in all cases evaluated (45/47) staging workup at diagnosis revealed no other sites of disease. Histologically all cases were remarkably similar and found incidentally, being composed of microscopic foci of large lymphoid cells, embedded within fibrin and not invading adjacent tissue structures. Most cases had a non-germinal center B-cell phenotype and high proliferative index. A strong association with EBV infection is present; as 41/43 evaluated were positive for EBV by EBER-ISH. Notably a type III EBV latency profile, with positivity for LMP-1 and Epstein-Barr nuclear antigen-2 (EBNA-2) was found in most cases (18/22 tested). Type III latency of EBV infection is the hallmark of lymphoproliferative disorders arising in the setting of severe immunosuppression. EBV-infected cells expressing EBNA-2 do not survive in immunocompetent individuals, because destroyed by cytotoxic T-lymphocytes. As patients with FA-DLBCL are immunocompetent, it has been assumed that the restricted environment where FA-DLBCL occurs, allows the EBV-infected B-cells to escape T-cell surveillance [9]. Clonal immunoglobulin rearrangement was identified in most cases evaluated. None of the cases tested by fluorescence in situ hybridization (FISH) showed c-MYC, BCL6 and/or BCL2 rearrangements or amplifications: a rather striking difference from PAL, presenting MYC amplification in 80% of cases [9]. Clinical course of FA-DLBCL is commonly indolent. Remarkably of 36 cases with available follow-up, 30 pursued a benign course, with no evidence of disease from 1 to 130 months. Treatment is variable, although surgery alone often represents the treatment of choice. Sixteen/30 cases were treated with surgery alone, 11 with surgery plus chemotherapy, 1 with surgery plus radiotherapy, 1 with surgery plus immunotherapy, and 1 with surgery plus chemotherapy and radiotherapy. All cases arising within pseudocysts behaved favorably. Local recurrences or persistent disease were seen only in isolated cases in which the primary disease had arisen either within an atrial myxoma (1) or at sites of previous vascular graft (2) [9]. The recurrent or persistent disease presented close to the site initially involved. Two/3 patients died of thromboembolic disease and 1 is alive with stable and localized disease. It has been hypothesized that FA-DLBCL arising at cardiac or vascular sites can recur or persist more easily than cases occurring in sites more amenable to complete surgical removal [9]. Kameda et al reported the unique case with an aggressive course, occurring in an elderly patient within a chronic subdural hematoma observed conservatively [1,24]. Seven months later, a de novo brain mass developed beneath the hematoma [24]. After surgical removal, the neoplasm within the subdural hematoma appeared consistent with FA-DLBCL and the brain mass was an EBV-positive DLBCL [24]. The authors hypothesized that the lymphoid process developed in the hematoma before infiltrating the brain parenchyma [24]. Once the lymphoma infiltrates outside the subdural hematoma, the prognosis becomes poor [1]. FA-DLBCL shares similarities with breast implant-associated anaplastic large B-cell lymphoma (BIA-ALCL), although the latter is a T/null lymphoma, not EBV-related [1]. Both entities portend a worse prognosis, when infiltrate the surrounding tissues outside the restricted space of origin. Our case arose in a previously unreported setting, being identified in a cerebral artery aneurysm of a patient with a brain hemorrhage. The disease was totally confined within thrombotic material occluding the artery. After surgical removal, it pursued a benign course with no additional treatment. In conclusion, FA-DLBCL is a rare EBV-related lymphoproliferative disorder, arising within fibrinous material in different clinical settings. Intracranial location is very rare. This represents the first report within a cerebral artery aneurysm. Diagnosis can be tricky, being FA-DLBCL not mass-forming and composed of tiny neoplastic foci. Clinical behavior is mostly indolent. The limited number of FA-DLBCL reported so far makes difficult to draw definitive conclusion regarding the best treatment. Further cases with longer follow-up would help to adopt the most appropriate therapeutic options for each individual patient. Abbreviations FA-DLBCL: Fibrin-associated diffuse large B-cell lymphoma; EBV: Epstein-Barr virus; WHO: World Health Organization; CT: Computed Tomography; DLBCL-CI: Diffuse large B-cell lymphoma associated with chronic inflammation; PAL: Pyothorax-associated lymphoma; EBER: EBV-encoded RNA; BIA-ALCL: breast implant-associated anaplastic large B-cell lymphoma. Declarations Ethics approval and consent to participate Local ethics committee (Comitato Etico dell'Area Vasta Emilia Nord, Italy) ruled that no formal ethics approval was required in this particular case. Patient gave consent to participate. Consent for publication Written informed consent was obtained from patient for publication of this Case Report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal. Availability of data and materials All the original data supporting our research are described in the Case presentation section and in the figures' legends. Competing interests The authors declare they have no competing interests. Funding The authors have no financial ties to disclose. Authors' contributions ZaM wrote the manuscript and performed literature review; AS performed histopathological examination and designed the study; MM studied the patient; GV, MG, DL, FOG, MMP performed literature review; ZiM was involved in review, editing and validation of the manuscript. All authors have read and approved the manuscript. Acknowledgements None. References Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Arber DA, Hasserjian RP, Le Beau MM, Orazi A, Siebert R (eds 2017). WHO classification of tumours of hematopoietic and lymphoid tissues. IARC, Lyon. Bagwan IN, Desai S, Wotherspoon A, Sheppard MN. Usual presentation of primary cardiac lymphoma. Interactive cardiovascular and thoracic surgery 2009 (9): 127-129. Dimitrova KR, Hoffman DM, Geller CM, thiagarjah P, Master J, Berger M, Tranbaugh RF. Malignant B-cell lymphoma arising in a large, left atrial mass. Ann Thorac Surg 2010; 89: 626-9. 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CT/BM staging: neg Surgery only NED at 42 mo Atrial myxoma Tapan 2015 (ref 8) 49/M negative Palpitations Foci of large lymphoid cells CD20+, CD79 a +, CD30+, MUM1+, CD3-, CD5-, CD10-, CD138-, cyclin D1-, ALK1-, EMA-. Ki67 80%. EBNA2+, EBER+. Ig clonality NP. NS Staging: neg BM neg Surgery + R-CHOP NED at 12 mo Atrial myxoma Boyer 2017 (ref 9) 54/F negative Syncope Foci of large lymphoid cells CD20+, PAX5+, CD79 a +, BCL6+, CD30+, CD10-, CD138- CD3-, HHV8-, Ki67 80%. EBER+. Ig clonality NP. NS Staging: neg Surgery Other therapy: NA NED at 130 mo Atrial myxoma Boyer 2017 (ref 9) 55/F negative Syncope, cough, dyspnea Foci of large lymphoid cells CD20+, PAX5+, CD79 a +, BCL6+, MUM1+, CD10-, CD45+, CD30+, HHV-8-, CD138-, CD3-. Ki67: >95%. EBER+, LMP1+, EBNA2+. FISH for MYC-. Ig clonality NP. NS Staging: neg Surgery only Died at 2 mo for cardiac cause. Autopsy: No lymphoma Atrial myxoma Boyer 2017 (ref 9) 54/M negative Dyspnea, respiratory failure Foci of large lymphoid cells CD20+, PAX5+, BCL6+, MUM1+, CD10-, CD38+, CD45+, CD30+, CD3-. Ki67:90% EBER+, LMP1+, EBNA2+. FISH MYC, BCL6, BCL2 -. Ig clonality NP. CT/BM Staging: neg Surgery only Recurrent FA-DLBCL at mitral valve after 25 mo. Died at 26 mo (embolic stroke). No autopsy. Atrial myxoma Yan 2017 (ref 9) 54/M negative Congestive heart failure Foci of large lymphoid cells within fibrin CD20+, CD79α+, MUM1+, CD10-, BCL6+, CD30+. ALK-, BCL2+, CD3-, CD5-, Ki67 90% LMP1+, EBNA-2+, EBER+, FISH for MYC, Bcl6, BCL2-. Ig clonality NP. CT/BM Staging: neg Surgery only NED at 7 MO Atrial myxoma Yan 2017 (ref 10) 61/F negative Congestive heart failure Foci of large lymphoid cells within fibrin CD20+, CD79α+, MUM1+, CD10+, BCL6+, CD30+. ALK-, BCL2+, CD3-, CD5-, Ki67 95% LMP1+, EBNA-2+, EBER+, FISH for MYC, Bcl6, BCL2-. Ig clonality NP. CT/BM Staging: neg Surgery only NED at 84 mo Atrial myxoma Yan 2017 (ref 10) 46/F negative Congestive heart failure Foci of large lymphoid cells within fibrin CD20+, CD79α+, MUM1+, CD10-, BCL6+, CD30+. ALK-, BCL2+, CD3-, CD5-, Ki67 90% LMP1+, EBNA-2+, EBER+, FISH for MYC, Bcl6, BCL2-. Ig clonality NP. CT/BM Staging: neg. Surgery only NED at 3 mo Atrial myxoma Yan 2017 (ref 10) 46/F negative Congestive heart failure Foci of large lymphoid cells within fibrin CD20+, CD79α+, MUM1+, CD10-, BCL6-, CD30+. ALK-, BCL2-, CD3-, CD5-, Ki67 85% LMP1+, EBNA-2+, EBER+, FISH for MYC, Bcl6, BCL2-. Ig clonality NP. CT/BM Staging: neg. Surgery only NED at 120 mo Atrial thrombus Qigley 2003 (ref 11) 29/M negative Cerebral embolic stroke Foci of large lymphoid cells at clot’s surface CD45+, CD20+, CD79 a + , CD43+, CD30+, CD3, LMP -, HHV8-, EBER+. Clonality: k rearrangement +. IGH -, TCR-. Imaging/BM Staging: neg Surgery+ R-CHOP (VI) NED at 24 mo Atrial thrombus Gruver 2012 (ref 12) 56/M negative short breath Foci of large lymphoid cells within fibrin thrombus CD20+, CD79 a +, PAX5+, CD30+, CD43-, CD45+, BCL6+, MUM1+, BCL2+, CD10-, CD3-, CD5-, HHV8-, MYC+30%; KI67 >90% LMP1+, EBNA2+.EBER+. Ig clonality +. NS Staging: neg Surgery+ R-CHOP (VI) NED at 8 mo Myxomatous mitral valve Gruver 2012 (ref 12) 75/M negative Dyspnea, aortic insufficiency, mitral valve regurgitation Foci of large lymphoid cells within fibrin on mitral valve CD20+, CD79 a +, PAX5+, CD30-, CD43-, CD45+, BCL6-, MUM1+, BCL2+, CD10-, CD3-, CD5-, HHV8-, MYC -. KI67100%. LMP1-, EBNA2-. EBER-. Ig clonality +. NS Staging: neg Surgery+R-CVP (I) +R-CHOP (VI) NED at 39 mo Prosthesis (knee) Cheuk 2005 (ref 13) 78/M negative Pain at knee prosthesis (implanted 22 yrs before) Foci of large lymphoid cells within fibrin and necrosis CD20+, CD79 a +, CD138+/-. CD2-, CD3-, CD5-, CD10- , BCL6-, HHV8-. Ki67:70%. LMP1+, EBER+. Ig clonality +. NS Staging: neg Surgery+RT NED at 24 mo Prosthesis (Aortic valve) Bagwan 2009 (ref 2) 50/M negative Symptoms of aortic regurgitation. Aortic valve prosthesis (16yrs before) Foci of large lymphoid cells within aortic valve leaflets CD45+, CD20+, CD79 a +, CD10+, BC6+/-, BCL2+/-, Ki67:80% LMP1-. Ig clonality: NP. NS Staging: neg BM: neg Surgery+ R-CHOP Died after 6mo for prosthesis rupture. Autopsy: no lymphoma Prosthesis (aortic valve) Berrio 2010 (ref 14) 60/M negative Acute left heart failure. History of aortic valve prosthesis for stenosis Foci of large lymphoid cells within valve vegetations CD20+, CD43+, CD3-. Ki67:80-90% EBV: NV. Ig clonality: NP. NS Staging: neg Surgery only Died for tricuspidal endocarditis, pneumonia 2yrs later. No autopsy. Prosthesis (aortic graft) Miller 2010 (ref 15) 48/M negative Ischemic attack. Marfan sy. Asc.a. aneurysm graft+ aortic valve prosthesis (24 yrs before) Foci of large lymphoid cells within fibrin CD20+, MUM1+, CD10-, BCL6- BCL2+, CD3-, HHV8-. EBER+. Ig clonality +. CT/PET/BM Staging: neg Surgery only NED at 6 mo Prosthesis (aortic valve) Miller 2010 (ref 15) 80/F negative Heart failure. Aortic valve prosthesis (8 yrs before) Foci of large lymphoid cells within fibrin CD20+, MUM1+, CD10-, BCL6-BCL2-, CD3-, HHV8-, EBER+. Ig clonality +. CT/PET/BM Staging: neg Surgery only Died (for breast cancer 18 mo after aortic valve surgery). No autopsy. Prosthesis (aortic graft) Miller 2010 (ref 15) 79/F negative Short breath, thoracic pulsing sensation. Tube graft for asc. a. dissection (5 yrs before) Foci of large lymphoid cells within fibrin CD20+, MUM1+, CD10-, BCL6+, BCL2+, CD3-, HHV8-, EBER+, Ig clonality +. CT/PET/BM Staging: neg Surgery only Died for surgical complications. No autopsy Prosthesis (aortic graft) Gruver 2012 (ref 12) 55/M negative Stroke. Aortic graft for aneurysm (4 yrs before) Foci of large lymphoid cells within thrombus CD20+, CD79 a +, PAX5+, CD30+, CD43+, CD45+, BCL6+, MUM1+, BCL2-, CD10-, CD3-, CD5-, HHV8-, MYC-; KI67 100%. LMP1+, EBNA2+.EBER+. Ig clonality +. NS Staging: neg Surgery + R-CEOP (VIII) NED at 16 mo Prosthesis (vascular graft) Boyer 2017 (ref 9) 56/M negative IR aorta+ CIA aneurysms. TAA aneurysm graft + thrombectomy (1 yr before). Asc a. dissection graft (9 yrs before). Foci of large lymphoid cells within thrombus of IR aorta and CIA aneurysms. In retrospect foci within thrombus of TAA aneurysm CD20+, PAX5+, BCL6-, MUM1+, CD10-, CD138-, HHV8-, CD30+, KI67: 95%. EBER+, LMP1+, EBNA2+. FISH for MYC -. Ig clonality +. CT/PET/BM Staging: neg Surgery+ R-CHOP (VI) + IT MTX AWSD at 24 mo. Surgical revision of aortic graft: persistent foci of EBV+ large B cell. Prosthesis (vascular graft) Boyer 2017 (ref 9) 68/M negative Lower limbs ischemia. AA aneurysm repair with IR graft (7 yrs before). Foci of large lymphoid cells within thrombus CD20+, PAX5+, BCL6+, CD10-MUM1+, CD30+, HHV8-, KI67 90%, EBER+, LMP1+, EBNA2+. FISH for MYC -. Ig clonality NP. CT/PET Staging neg. 3 mo after: PET/CT/biopsy: foci of EBV+ cells near adrenal gland. R-COEP (II) Died at 10 mo for embolic stroke. No progressive lymphoma. No autopsy Prosthesis (vascular) Boyer 2017 (ref 9) 71/M MG for THY treated with surgery+ steroids+ AZA AF graft (6 yrs before). Foci of large lymphoid cells within thrombus associated with graft CD20+, CD79 a +, PAX5+, CD10-BCL6+, MUM1+, CD30+, CD45+, CD138-, HHV8-, KI67>95%, EBER+, LMP1+. Ig clonality +. NS Staging: neg Surgery only NED at 10 mo Pseudocyst (kidney) Lee 2009 (ref 16) 61/M negative Renal cyst (for 20 yrs) Foci of large lymphoid cells within necrosis CD22+, CD45+, CD79 a +, MUM1+, PAX5+, CD3-, CD10-, CD20-, CD138-, BCL6-, ALK1-, HHV8-, k -, l -, EBER+. Ig clonality NP. Staging NA Surgery+ CHOP (VI) NA Pseudocyst (spleen) Loong 2010 (ref 4) 29/M negative Abdominal pain Foci of large lymphoid cells within necrosis CD20+, CD79 a +, PAX5+, CD43+, MUM1+, CD10-, BCL6-CD138-, BCL2+, CD30-, HHV8-, CD3-. Ki67 90%. LMP1+, EBNA2+, EBER+. Ig clonality +. PET/BM Staging: neg Surgery (splenectomy)+ R (IV) NED at 6 mo Pseudocyst (kidney) Valli 2011 (ref 17) 46/M negative Left-sided flank pain Foci of large lymphoid cells within necrosis CD20+, MUM1+, CD10-, BCL6-BCL2+, CD30-, HHV8-;Ki67:90%. EBER+. Ig clonality NP. CT/PET/BM Staging: neg Surgery+ R-CHOP (VI) NED at 1 mo Pseudocyst (adrenal gland) Boroumand 2012 (ref 18) 63/F negative Right abdominal pain Foci of large lymphoid cells within fibrin CD20+, CD79 a +, PAX5+, MUM1+, BCL2+, CD3-, CD10-, CD30- , BCL6-, HHV8-. Ki67 >90%. LMP1-; EBER+. Ig clonality NP. NS Staging: neg Surgery + R-CHOP (VI)+RT NED at 40 mo Pseudocyst (testis) Boroumand 2012 (ref 18) 27/M negative R. scrotal swelling. Herniorraphy followed by l. scrotal hematoma (removed 3 yrs before) Foci of large lymphoid cells within fibrin CD20+, CD79 a +, CD30+, MUM1+, BCL2+, CD3-, CD10- BCL6-, HHV8-. Ki67>90%. LMP1+, EBER+. Ig clonality NP. NS Staging: neg Surgery only NED at 9 mo Pseudocyst (spleen) Boyer 2017 (ref 9) 37/F negative Splenic mass (9 cm), incidentally found Foci of large lymphoid cells within fibrin CD20+, PAX5+, MUM1+, CD10-BCL6-, CD30-, CD45+, KI67>90% EBER+. Ig clonality NP. CT/PET/BM Staging: neg. Surgery + R-CHOP (III) NED at 32 mo Pseudocyst (retrop.) Boyer 2017 (ref 9) 73/M negative Femoral a. aneurysm repair Foci of large lymphoid cells within fibrin CD20+, PAX5+, CD79 a +, BCL6-, CD10-, MUM1+, CD30+, CD45+, HHV8-, KI67>95%, EBER+. Ig clonality NP. CT/BM Staging: neg Surgery+ R-CHOP (VI) NED at 43 mo Pseudocyst (adrenal gland) Boyer 2017 (ref 9) 70/M negative Adrenal mass (7 cm) causing bladder obstruction Foci of large lymphoid cells within fibrin CD20-, PAX5+, CD79 a +, BCL6-, CD10-, MUM1+, CD45+, CD30+, CD138-, HHV8-, KI67>90%, LMP1-, EBNA2+, EBER+. FISH for MYC -. Ig clonality NP. CT/PET Staging: neg Surgery only NED at 14 mo Pseudocyst (retrop.) Boyer 2017 (ref 9) 44/M negative Right flank pain Foci of large lymphoid cells within fibrin CD20+, PAX5+, CD10-, BCL6-, MUM1+, CD45+, CD30-, KI67 40%, LMP1+, EBNA2+, EBER+, FISH for MYC -. Ig clonality +. BM/imaging Staging: neg 5-CHOP NED at 84 mo Pseudocyst (adrenal gland) Zanelli 2019 (ref 19) 71/F negative Lower limbs edema+ abdominal distension Foci of large lymphoid cells within fibrin CD20+, PAX5+, CD30+, MUM1+, CD10-, BCL6-, EBER+, Ki67 90%. Ig clonality NP. CT Staging: neg Surgery only NED at 6 mo Teratoma (ovary) Valli 2014 (ref 20) 56/F negative Abdominal pain+ swelling Foci of large lymphoid cells CD20+, MUM1+, CD45+, PAX5+, CD30-, BCL6-, CD10-, CD3-, CD2-, HHV8-, CD138-. Ki67: 80%. EBER+. Ig clonality +. CT/PET Staging: neg Surgery+ R-CHOP (VI) NED at 8 mo Hydrocele (testis) Loong 2010 (ref 4) 88/M negative Fever, scrotal pain, swelling Foci of large lymphoid cells within necrosis CD20+, CD79 a +, PAX5+, MUM1+, CD10-, BCL6-, CD138-, BCL2+, CD30-, HHV8-, CD3+, CD2-, CD5-, CD7-. Ki67 70% LMP1+, EBNA2+, EBER+. Ig clonality -. Staging NA Surgery only (Orchidectomy) NA Hematoma (testis) Boyer 2017 (ref 9) 79/M negative Testicular trauma (5 yrs before) Foci of large lymphoid cells within hematoma CD20+, PAX5+, CD79 a +, CD10-CD138-, BCL6-, MUM1+, CD45+, CD30+, HHV8-, KI67 > 90%, EBER+, LMP1+, EBNA2+. Ig clonality +. NS Staging: neg. Surgery only NED. Died at 17 mo Hematoma (thigh) Hayes 2014 (ref 21) 91/M negative Thigh hematoma. (6 yrs before leg amputation for popl. a. aneurysm rupture at prior artery bypass graft site) Foci of large lymphoid cells CD45+, CD20+, MUM1+, CD30+, CD43+, BCL2+/-, MYC+, p53+/-, HHV8-, CD3-, CD5-, CD10-, BCL1-, BCL6-. Ki67: 90%. LMP1-, EBER+. Ig clonality NP. NS Staging: neg Surgery only. NED at 18 mo Subdural hematoma Reyes 1990 (ref 22) 56/M negative Headaches, dizziness, unsteady gait Foci of large lymphoid cells within fibrin, clots, necrosis B-cell phenotype. EBV NV. Ig clonality NP. CT/BM Staging: neg Surgery only NA Subdural hematoma Sugita 2012 (ref 23) 77/M negative Dementia due to head trauma (20 yrs before) Foci of large lymphoid cells CD20+, CD79 a +, MUM1+, CD3-, BCL6-, CD10-. Ki67 high. EBNA2+, LMP1-, EBER+. Ig clonality - (rare neoplastic foci). Imaging Staging: neg Surgery only NA Subdural hematoma Kameda 2015 (ref 24) 96/M negative Gait disturbs+ anorexia. Trauma+ subdural hematoma (7 mo before). Brain mass: DLBCL EBV+. Subdural hematoma: FA-DLBCL. No continuity among 2 lesions CD20+, CD79 a +, CD3-, CD4-, CD7-, CD8-, LMP1+, EBNA2+, EBER+. Ig clonality NP. CT Staging: neg at presentation. Brain mass+ subdural hematoma resection. IT MTX + cytarabine+ glucocorticoids Died after 3 mo for lymphoma dissemination. No autopsy Subdural hematoma Boyer 2017 (ref 9) 25/M negative SD hematoma since child. Hydrocephalus+ SD catheter. Steroid tp for pituitary overactivity Foci of large lymphoid cells within hematoma CD20+, PAX5+, MUM1+, CD10-BCL6-, CD30+, HHV8-, KI67>90%; EBER+, LMP1+. Ig clonality NP. CT/PET/BM Staging: neg. Surgery only NED at 7 mo Arachnoid cyst Kirshenbaum 2017 (ref 25) 81/M negative Tremor, gait ataxia, memory disturbs Foci of large lymphoid cells within fibrin CD20+ CD30+, BCL2+, MUM1+, BCL6+/-, CD10-, TdT-, CD5-, cMYC+ (50%) Ki67: >80%. EBER+. FISH MYC -. Ig clonality +. CT/PET staging: neg Surgery (cyst excision)+ R-lenalidomide NA Cerebral artery aneurysm Present case 64/F negative Cerebral hemorrhage. Left middle cerebral artery aneurysm Foci of large lymphoid cells within fibrin CD20+/-, PAX5+, CD79 a +, CD30+, MUM1+, CD10-, BCL6-, EBER+, Ki67 90%. Ig clonality NP. CT/BM Staging: neg Surgery only NED at 5 mo LITERATURE REVIEW OF FIBRIN-ASSOCIATED DIFFUSE LARGE B-CELL LYMPHOMA A: artery; AA: abdominal aorta; AF: aortofemoral; Asc. A: ascending aorta; AWSD: alive with stable disease; AZA: azathioprine; BM: bone marrow; CEOP: cyclophosphamide, etoposide, oncovin, prednisone; CHOP: cyclophosphamide, doxorubicin, vincristine, prednisone; retro: retroperitoneum CIA: common iliac arteries; CH: chemotherapy; CVP: cyclophosphamide, vincristine, prednisone; CT: Computerized tomography; DEXA: dexamethasone; F: female; IT: intrathecal; IR: infrarenal; Ig: immunoglobulin: IGH: immunoglobulin heavy chain; mo: months; M: male; MTX: methotrexate; MG: myasthenia gravis; NA: not available; NED: not evidence of disease; Neg: negative; NP: not performed; NS: not specified; PBL: plasmablastic lymphoma; popl. A: popliteal artery; R: rituximab; Retrop: retroperitoneum; RT: radiotherapy; SD: subdural; sy: syndrome; TAA: thoracoabdominal aorta; TCR: T cell receptor; THY: Thymoma; Tp: therapy; yrs: years. Supplementary Files CAREChecklist.pdf Cite Share Download PDF Status: Published Journal Publication published 13 Sep, 2019 Read the published version in BMC Cancer → Version 3 posted Submission checks completed at journal 18 Nov, 2019 Editorial decision: Accept 21 Aug, 2019 Editor assigned by journal 20 Aug, 2019 Editor invited by journal 19 Aug, 2019 You are reading this latest preprint version Show more versions Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-2924","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Case report","associatedPublications":[],"authors":[{"id":157060,"identity":"38d882d3-b0fb-49bb-8f5a-811de8fd7331","order_by":1,"name":"Magda Zanelli","email":"","orcid":"","institution":"AUSL-IRCCS di Reggio emilia","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Magda","middleName":"","lastName":"Zanelli","suffix":""},{"id":157061,"identity":"2941ff83-c1e8-4666-aa1e-785f56d96f5d","order_by":2,"name":"Maurizio Zizzo","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA6ElEQVRIie2QsQrCMBCGEw7qYnF1EZ9B3H0RF0tXsxfUWijYRXBNQfQVdIlrSqAugg/govgC7dbRaycVau0mmG84/uG+hP8I0Wh+EXgKkjh5AK+OcsoDrVBeoItifla6QeOepOOBdQgaN5luZsNWgErmiPJ3fTLqhcK21oqMolAcGVfUo8vTpbwKEGmbAiyOQZkiZh4qQBflioFlcXOOSh7WMdtWKU0A6ptCoQJEmd6U7aqUNuA/WKHPwSARjyXboxJ96tJdHfFiYtLhLQzJ1GWbs4qumVOuvKOKKb/eR9w6yxqNRvMnPABySVjR5UaPVwAAAABJRU5ErkJggg==","orcid":"https://orcid.org/0000-0001-9841-7856","institution":"Arcispedale Santa Maria Nuova di Reggio Emilia","correspondingAuthor":true,"submittingAuthor":false,"prefix":"","firstName":"Maurizio","middleName":"","lastName":"Zizzo","suffix":""},{"id":157062,"identity":"77e010bb-47ac-4bb4-a4d6-e4d971f6fd15","order_by":3,"name":"Marco Montanaro","email":"","orcid":"","institution":"Ospedale di Belcolle, Viterbo","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Marco","middleName":"","lastName":"Montanaro","suffix":""},{"id":157063,"identity":"e31aba73-b8df-4908-a08e-aa10693e88d4","order_by":4,"name":"Vito Gomes","email":"","orcid":"","institution":"Ospedale di Belcolle, Viterbo","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Vito","middleName":"","lastName":"Gomes","suffix":""},{"id":157064,"identity":"f3213907-2ee2-4907-8282-fe2ef822b3e6","order_by":5,"name":"Giovanni Martino","email":"","orcid":"","institution":"University of Perugia","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Giovanni","middleName":"","lastName":"Martino","suffix":""},{"id":157065,"identity":"ed85c17a-7f99-47d4-bcd7-ca85a6732a60","order_by":6,"name":"Loredana De Marco","email":"","orcid":"","institution":"AUSL-IRCCS di Reggio Emilia","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Loredana","middleName":"","lastName":"De Marco","suffix":""},{"id":157066,"identity":"e56bccc1-9aa6-4b48-b295-1a3e736c9e6c","order_by":7,"name":"Giulio Fraternali Orcioni","email":"","orcid":"","institution":"Azienda Opedaliera S. Croce e Carle, Cuneo","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Giulio","middleName":"Fraternali","lastName":"Orcioni","suffix":""},{"id":157067,"identity":"f1c0f901-eb3b-48d8-97a9-fe2178e1cd9a","order_by":8,"name":"Maria Paola Martelli","email":"","orcid":"","institution":"University of Perugia","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Maria","middleName":"Paola","lastName":"Martelli","suffix":""},{"id":157068,"identity":"98655a70-2998-452c-b2a9-dd6131be7c6d","order_by":9,"name":"Stefano Ascani","email":"","orcid":"","institution":"Ospedale di Terni","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Stefano","middleName":"","lastName":"Ascani","suffix":""}],"badges":[],"createdAt":"2019-07-24 18:25:09","currentVersionCode":3,"declarations":"","doi":"10.21203/rs.2.12131/v3","doiUrl":"https://doi.org/10.21203/rs.2.12131/v3","draftVersion":[],"editorialEvents":[{"content":"https://doi.org/10.1186/s12885-019-6123-1","type":"published","date":"2019-09-13T12:00:00+00:00"}],"editorialNote":"","failedWorkflow":false,"files":[{"id":123037,"identity":"ed568877-49bf-4c98-b0ba-e9ab25e6fcf4","added_by":"auto","created_at":"2019-10-12 12:26:24","extension":"png","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":61517705,"visible":true,"origin":"","legend":"Low power view of artery with interrupted wall and containing thrombotic material (HE 4x); inset Rare atypical lymphoid cells lying within the thrombus are recognizable at high power view (HE 20x).","description":"","filename":"Figure1.png","url":"https://assets-eu.researchsquare.com/files/b781bd1c-0841-4a34-8b02-f5d81d00111e/v3/Figure 1.png"},{"id":123039,"identity":"366d8058-790b-405b-b364-0ab332efa315","added_by":"auto","created_at":"2019-10-12 12:26:43","extension":"png","order_by":2,"title":"Figure 2","display":"","copyAsset":false,"role":"figure","size":57209569,"visible":true,"origin":"","legend":"High power detail of large lymphoid cells (HE 40x); inset left PAX5 positivity of lymphoid cells; inset right MUM1 expression of lymphoid cells.","description":"","filename":"Figure2.png","url":"https://assets-eu.researchsquare.com/files/b781bd1c-0841-4a34-8b02-f5d81d00111e/v3/Figure 2.png"},{"id":123040,"identity":"5444c9f8-a310-4aef-9f4b-1039acd34955","added_by":"auto","created_at":"2019-10-12 12:26:43","extension":"png","order_by":3,"title":"Figure 3","display":"","copyAsset":false,"role":"figure","size":41569689,"visible":true,"origin":"","legend":"High proliferative index (Ki67) (A); Epstein-Barr virus positivity in large-sized cells by in situ hybridization for EBV-encoded RNA (EBER) (B).","description":"","filename":"Figure3.png","url":"https://assets-eu.researchsquare.com/files/b781bd1c-0841-4a34-8b02-f5d81d00111e/v3/Figure 3.png"},{"id":13476799,"identity":"da2dd8f0-a584-4f03-a452-459f34785498","added_by":"auto","created_at":"2021-09-16 21:28:51","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":444317,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-2924/v3/59ad5fc5-fb57-46bb-a476-23faed3f580e.pdf"},{"id":123038,"identity":"b865aa4c-67ef-4ad0-8dab-b4dfbbc163b3","added_by":"auto","created_at":"2019-10-12 12:26:24","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"supplement","size":76109,"visible":true,"origin":"","legend":"","description":"","filename":"CAREChecklist.pdf","url":"https://assets-eu.researchsquare.com/files/b781bd1c-0841-4a34-8b02-f5d81d00111e/v3/CARE Checklist.pdf"}],"financialInterests":"","formattedTitle":"Fibrin-Associated Large B-Cell Lymphoma: First Case Report Within A Cerebral Artery Aneurysm And Literature Review","fulltext":[{"header":"Introduction","content":"\u003cp\u003eIn the current WHO classification, diffuse large B-cell lymphoma associated with chronic inflammation (DLBCL-CI) is defined as an EBV-driven neoplasm, occurring in longstanding chronic inflammation in restricted spaces [1]. The prototype is pyothorax-associated lymphoma (PAL) arising in patients with a long history of pyothorax, following artificial pneumothorax as treatment for tuberculosis [1]. Recently, another EBV-related entity has been included among DLBCL-CI, but renamed fibrin-associated diffuse large B-cell lymphoma (FA-DLBCL) because it develops within fibrinous material [1].\u003c/p\u003e\n\u003cp\u003eIt has been reported in association with pseudocysts, cardiac myxoma, valve prosthesis, fibrin thrombus, synthetic tube graft, hydrocele, metallic implants, and chronic subdural hematoma [1-25]. Differently from PAL, it does not form masses, being composed of rare neoplastic cells and it represents often an incidental finding [1]. Whereas PAL follows an aggressive course, the majority of FA-DLBCL behave favorably and may not require therapies other than surgery. Rare cases with persistent or localized recurrent disease have been described [9]. Only one case with a poor outcome has been reported so far [24]. We present the first report of FA-DLBCL incidentally disclosed in a cerebral artery aneurysm, widening the clinicopathological spectrum of this rare entity.\u003c/p\u003e"},{"header":"Case presentation","content":"\u003cp\u003eA 64-year-old immunocompetent woman was referred to hospital for cerebral hemorrhage in left temporal-parietal region. CT angiography detected an aneurysm in the distal segment of left middle cerebral artery. Tiny fragments of brain tissue together with partially organized thrombus were surgically removed. Histologically, it was identified an artery, with an interrupted wall, occluded by thrombotic material (Fig. 1). Small foci of large atypical lymphoid cells (Fig. 1, \u003cem\u003einset\u003c/em\u003e; Fig. 2) were disclosed within thrombus. The cells were positive for PAX5 (Fig. 2, \u003cem\u003einset left\u003c/em\u003e), CD30 and MUM1 (Fig. 2, \u003cem\u003einset right\u003c/em\u003e) with partial expression of CD79\u0026alpha; and CD20. The proliferative index (Fig. 3 A) was high (Ki67 about 90%). The cells expressed LMP-1 and were diffusely positive for EBV by in situ hybridization for EBV-encoded RNA (EBER) (Fig. 3, B). Clonal immunoglobulin heavy chain (IGH) rearrangement was detected. A fibrin-associated diffuse large B-cell lymphoma was diagnosed. Staging procedures (CT scan and bone marrow biopsy) were negative. Three months later, CT scan showed an almost complete hemorrhage resorption. No further treatment was given. The patient is alive, free of disease at 8 months from diagnosis.\u003c/p\u003e"},{"header":"Discussion and Conclusions","content":"\u003cp\u003eFA-DLBCL is a rare EBV-associated B-cell lymphoma included in the current WHO classification, in the chapter of DLBCL-CI [1]. Differently from DLBCL-CI, it is not mass-forming and therefore disclosed incidentally on histological evaluation of surgical specimens removed for other diseases [1]. 47 cases, including our, have been reported so far [1-25]. Clinicopathological data are summarized in Table 1. It shows male predominance with a wide age range. No ethnic differences have been apparently identified so far [9]. All cases, except 2 [9], occurred in immunocompetent individuals, presenting with different symptoms, depending on the underlying conditions in which FA-DLBCL occurred.\u003c/p\u003e\n\u003cp\u003eCardiac myxoma represents one of the most frequent site of occurrence with 14 cases identified, whereas only occasional cases arose in atrial thrombi and within mixomatous valve degeneration. Some cases have been identified in association with prosthetic devices such as endovascular graft, cardiac valve prosthesis and metallic implant. Time from placement of devices to lymphoma diagnosis is extremely variable, ranging from 1 to more than 20 years. A rather frequent site of presentation is represented by pseudocysts, with a total of 10 cases, in different organs (adrenal gland, spleen, kidney, retroperitoneum, testis). Single descriptions at unusual sites as within testicular hydrocele, ovarian teratoma and testicular hematoma are also reported. The intracranial location appears to be rare, with only 4 cases within chronic subdural hematomas\u003csup\u003e9,22,23,24,\u003c/sup\u003e and 1 within an arachnoid cyst\u003csup\u003e25\u003c/sup\u003e. Our case represents the first report in a patient with a brain hemorrhage and incidentally identified within thrombotic material in a cerebral artery aneurysm. Notably in all cases evaluated (45/47) staging workup at diagnosis revealed no other sites of disease.\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;Histologically all cases were remarkably similar and found incidentally, being composed of microscopic foci of large lymphoid cells, embedded within fibrin and not invading adjacent tissue structures. Most cases had a non-germinal center B-cell phenotype and high proliferative index. A strong association with EBV infection is present; as 41/43 evaluated were positive for EBV by EBER-ISH. Notably a type III EBV latency profile, with positivity for LMP-1 and Epstein-Barr nuclear antigen-2 (EBNA-2) was found in most cases (18/22 tested). Type III latency of EBV infection is the hallmark of lymphoproliferative disorders arising in the setting of severe immunosuppression. EBV-infected cells expressing EBNA-2 do not survive in immunocompetent individuals, because destroyed by cytotoxic T-lymphocytes. As patients with FA-DLBCL are immunocompetent, it has been assumed that the restricted environment where FA-DLBCL occurs, allows the EBV-infected B-cells to escape T-cell surveillance [9]. Clonal immunoglobulin rearrangement was identified in most cases evaluated. None of the cases tested by fluorescence in situ hybridization (FISH) showed c-MYC, BCL6 and/or BCL2 rearrangements or amplifications: a rather striking difference from PAL, presenting MYC amplification in 80% of cases [9]. Clinical course of FA-DLBCL is commonly indolent. Remarkably of 36 cases with available follow-up, 30 pursued a benign course, with no evidence of disease from 1 to 130 months. Treatment is variable, although surgery alone often represents the treatment of choice. Sixteen/30 cases were treated with surgery alone, 11 with surgery plus chemotherapy, 1 with surgery plus radiotherapy, 1 with surgery plus immunotherapy, and 1 with surgery plus chemotherapy and radiotherapy. All cases arising within pseudocysts behaved favorably. Local recurrences or persistent disease were seen only in isolated cases in which the primary disease had arisen either within an atrial myxoma (1) or at sites of previous vascular graft (2) [9]. The recurrent or persistent disease presented close to the site initially involved. Two/3 patients died of thromboembolic disease and 1 is alive with stable and localized disease. It has been hypothesized that FA-DLBCL arising at cardiac or vascular sites can recur or persist more easily than cases occurring in sites more amenable to complete surgical removal [9]. Kameda \u003cem\u003eet al\u003c/em\u003e reported the unique case with an aggressive course, occurring in an elderly patient within a chronic subdural hematoma observed conservatively [1,24]. Seven months later, a de novo brain mass developed beneath the hematoma [24]. After surgical removal, the neoplasm within the subdural hematoma appeared consistent with FA-DLBCL and the brain mass was an EBV-positive DLBCL [24]. The authors hypothesized that the lymphoid process developed in the hematoma before infiltrating the brain parenchyma [24]. Once the lymphoma infiltrates outside the subdural hematoma, the prognosis becomes poor [1]. FA-DLBCL shares similarities with breast implant-associated anaplastic large B-cell lymphoma (BIA-ALCL), although the latter is a T/null lymphoma, not EBV-related [1]. Both entities portend a worse prognosis, when infiltrate the surrounding tissues outside the restricted space of origin.\u003c/p\u003e\n\u003cp\u003eOur case arose in a previously unreported setting, being identified in a cerebral artery aneurysm of a patient with a brain hemorrhage. The disease was totally confined within thrombotic material occluding the artery. After surgical removal, it pursued a benign course with no additional treatment.\u003c/p\u003e\n\u003cp\u003eIn conclusion, FA-DLBCL is a rare EBV-related lymphoproliferative disorder, arising within fibrinous material in different clinical settings. Intracranial location is very rare. This represents the first report within a cerebral artery aneurysm. Diagnosis can be tricky, being FA-DLBCL not mass-forming and composed of tiny neoplastic foci. Clinical behavior is mostly indolent. The limited number of FA-DLBCL reported so far makes difficult to draw definitive conclusion regarding the best treatment. Further cases with longer follow-up would help to adopt the most appropriate therapeutic options for each individual patient.\u003c/p\u003e"},{"header":"Abbreviations","content":"\u003cp\u003eFA-DLBCL: Fibrin-associated diffuse large B-cell lymphoma; EBV: Epstein-Barr virus; WHO: World Health Organization; CT: Computed Tomography; DLBCL-CI: Diffuse large B-cell lymphoma associated with chronic inflammation; PAL: Pyothorax-associated lymphoma; EBER: EBV-encoded RNA; BIA-ALCL: breast implant-associated anaplastic large B-cell lymphoma.\u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003e\u003cstrong\u003eEthics approval and consent to participate\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eLocal ethics committee (Comitato Etico dell'Area Vasta Emilia Nord, Italy) ruled that no formal ethics approval was required in this particular case.\u003c/p\u003e\n\u003cp\u003ePatient gave consent to participate.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConsent for publication\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eWritten informed consent was obtained from patient for publication of this Case Report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAvailability of data and materials\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eAll the original data supporting our research are described in the Case presentation section and in the figures' legends.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eCompeting interests\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe authors declare they have no competing interests.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eFunding\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe authors have no financial ties to disclose.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAuthors' contributions\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eZaM wrote the manuscript and performed literature review; AS performed histopathological examination and designed the study; MM studied the patient; GV, MG, DL, FOG, MMP performed literature review; ZiM was involved in review, editing and validation of the manuscript. All authors have read and approved the manuscript.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAcknowledgements\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNone.\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\n\u003cli\u003eSwerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Arber DA, Hasserjian RP, Le Beau MM, Orazi A, Siebert R (eds 2017). WHO classification of tumours of hematopoietic and lymphoid tissues. IARC, Lyon.\u003c/li\u003e\n\u003cli\u003eBagwan IN, Desai S, Wotherspoon A, Sheppard MN. Usual presentation of primary cardiac lymphoma. Interactive cardiovascular and thoracic surgery 2009 (9): 127-129.\u003c/li\u003e\n\u003cli\u003eDimitrova KR, Hoffman DM, Geller CM, thiagarjah P, Master J, Berger M, Tranbaugh RF. Malignant B-cell lymphoma arising in a large, left atrial mass. Ann Thorac Surg 2010; 89: 626-9.\u003c/li\u003e\n\u003cli\u003eLoong F, Chan ACL, Ho BCS, Chau YP, Lee HY, Cheuk W, Yuen WK, Ng WS, Cheung HL, Chan JKC. Diffuse large B-cell lymphoma associated with chronic inflammation as an incidental finding and new clinical scenarios. Modern Pathology 2010; 23: 493-501.\u003c/li\u003e\n\u003cli\u003eSvec A, Rangaiah M, Giles M, Jaksa R, Mc Aulay KA. EBV+ diffuse large B-cell lymphoma arising within atrial myxoma. An example of a distinct primary EBV+ DLBCL of immunocompetent patients. Pathology Research and Practise 2012; 208: 172-176.\u003c/li\u003e\n\u003cli\u003eBartoloni G, Pucci A, Giorlandino A, Berretta M, Mignosa C, Italia F, Carbone A, Canzonieri V. Incidental Epstein-Barr virus associated atypical lymphoid proliferation arising in a left atrial myxoma: a case of long survival without any postsurgical treatment and review of the literature. Cardiovascular Pathology 2013; 22: 5-10.\u003c/li\u003e\n\u003cli\u003eAguilar C, Beltran B, Quinones P, Carbajal T, Vilcapaza J, Yabar A, Segura P, Quintanilla-Martinez L, Miranda RN, Castillo JJ. Large B-cell lymphoma arising in cardiac myxoma or intracardiac fibrinous mass. A localized lymphoma usually associated with Epstein-Varr virus? Cardiovascular Pathology 2015; 24: 60-64.\u003c/li\u003e\n\u003cli\u003eTapan U, Pestana JB, Lee JC, Lerner A. Epstein-Barr virus-associated diffuse large B-cell lymphoma arising in atrial myxoma: a proposal for a modified therapeutic approach. Leukemia lymphoma 2015; 56 (2): 505-507.\u003c/li\u003e\n\u003cli\u003eBoyer DF, McKelvie PA, de Leval L, Edlefsen KL, Ko YH, Aberman ZA, Kovach AE, Masih A, Nishino HT, Weiss LM, Meeker AK, Nardi V, Palisoc M, Shao L, Pittaluga S, Ferry JA, Lee Harris N, Sohani AR. Fibrin-associtaed EBV-positive large B-cell lymphoma. An indolent neoplasm with features distinct from diffuse large B-cell lymphoma associated with chronic inflammation. Am J Surg Pathol 2017; 41: 299-312.\u003c/li\u003e\n\u003cli\u003eYan J, Luo D, Zhang F, He J, Yao S, Luo X, Hu F, Chen Y, Fu L, Xu J, Liu Y. Diffuse large B-cell lymphoma associated with chronic inflammation arising within atrial myxoma: aggressive histological but indolent clinical behaviour. Histopathology 2017, 71: 951-959.\u003c/li\u003e\n\u003cli\u003eQuiley MM, Schwartzman E, Boswell PD, Christensen RL, Gleason LA, Sharpe RW, d\u0026rsquo;Amato TA. A unique atrial primary cardiac lymphoma mimicking myxoma presenting with embolic stroke: a case report. Blood 2003; 101: 4708-4710.\u003c/li\u003e\n\u003cli\u003eGruver AM, Huba MA, Dogan A, His ED. Fibrin-associated large B-cell lymphoma. Part of the spectrum of cardiac lymphomas. Am J Surg Pathol 2012; 36: 1527-1537.\u003c/li\u003e\n\u003cli\u003eCheuk W, Chan ACL, Chan JKC, Lau GTC, Chan VNH, Yiu HHY. Metallic implant-associated lymphoma. A distinct subgroup of large B-cell lymphoma related to pyothorax-associated lymphoma? Am J Surg Pathol 2005; 29: 832-836.\u003c/li\u003e\n\u003cli\u003eBerrio G, Suryadevara A, Singh NK, Wesly OH. Diffuse large B-cell lymphoma in an aortic valve allograft. Images in cardiovascular medicine 2010; 37 (4): 492-3.\u003c/li\u003e\n\u003cli\u003eMiller DV, Firchau DJ, Mc Clure RF, Kurtin PJ, Feldman AL. Epstein-Barr virus-associated diffuse large B-cell lymphoma arising on cardiac prosthesis. Am J Surg Pathol 2010; 34: 377-384.\u003c/li\u003e\n\u003cli\u003eLee MC, Aron M, His ED, Herts BR, Pohlman B, Gill IS. Age-related Epstein-Barr virus-associated lymphoproliferative disorder presenting as renal mass. Urology 2009; 74 (3): 505-508.\u003c/li\u003e\n\u003cli\u003eValli R, Piana S, Capodanno I, Cavazza A. Diffuse large B-cell lymphoma associated with chronic inflammation arising in a renal pseudocyst. J. Surg Pathol 2011; 19 (1): 117-119.\u003c/li\u003e\n\u003cli\u003eBoroumand N, Ly TL, Sonstein J, Medeiros LJ. Microscopic diffuse large B-cell lymphoma (DLBCL) occurring in pseudocysts. Do these tumors belong to the category of DLBCL associated with chronic inflammation?. Am J. Surg Pathol 2012; 36: 1074-1080.\u003c/li\u003e\n\u003cli\u003eZanelli M, Zizzo M, Loredana De Marco, Bisagni A, Ascani S. Fibrin-associated diffuse large B-cell lymphoma. Br J Haematol. 2019; 185(3): 397.\u003c/li\u003e\n\u003cli\u003eValli R, Froio E, Alvarez De Celis MI, Mandato VD, Piana S. Diffuse large B-cell lymphoma occurring in an ovarian cystica teratoma: expanding the spectrum of large B-cell lymphoma associated with chronic inflammation. Human Pathology 2014; 45: 2507-2511.\u003c/li\u003e\n\u003cli\u003eHayes C, Alkan S, Kitahara S. Indolent fibrin-associated EBV-positive large B-cell lymphoproliferative disorder in a lower extremity aneurysmal hematoma: a case report. J Hematopathol 2014; 7: 139-143.\u003c/li\u003e\n\u003cli\u003eReyes M.G, Homsi MF, Mangkornkanong M, Stone J, Glick RP. Malignant lymphoma presenting as a chronic subdural hematoma. Surg Neurol 1990; 33:35-6.\u003c/li\u003e\n\u003cli\u003eSugita Y, Ohta M, Ohshima K, Niino D, Nakamura Y, Okada Y, Nakashima S. Epstein-Barr virus-positive lymphoproliferative disorder associated with old organized chronic subdural hematoma. Pathology International 2012; 62: 412-417.\u003c/li\u003e\n\u003cli\u003eKameda K, Shono T, Takagishi S, Kono S, Aoki T, Ito Y, Kamimura T, Sugita Y, ohshima K. Epstein-Barr virus-positive diffuse large B-cell primary central nervous system lymphoma associated with organized chronic subdural hematoma: a case report and review of the literature. Pathology International 2015; 65: 138-143.\u003c/li\u003e\n\u003cli\u003eKirschenbaum D, Prommel P, Vasella F, Haralambleva E, Maggio EM, Reisch R, Beer M, Camenisch U, Rushing EJ. Fibrin-associated diffuse large B-cell lymphoma in a hemorrhagic cranial arachnoid cyst. Acta neuropatologica communications 2017; 5:60.\u003c/li\u003e\n\u003c/ol\u003e"},{"header":"Tables","content":"\u003cp\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eTable 1.\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e Demographic data, clinical data, and characteristics of reported cases of Fibrin-Associated Diffuse Large B-Cell Lymphoma\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"margin-left: -2.2pt; border-collapse: collapse;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 23.7pt;\"\u003e\n\u003ctd style=\"width: 72.6pt; border: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 23.7pt;\" width=\"97\"\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eAtrial myxoma\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e \u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eAguilar 2015 (ref 7)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; border: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 23.7pt;\" width=\"47\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e52/M\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 62.1pt; border: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 23.7pt;\" width=\"83\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003enegative\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; border: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 23.7pt;\" width=\"132\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eDysarthria and hemiplegia\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 23.7pt;\" width=\"123\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eFoci of large lymphoid cells\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 134.65pt; border: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 23.7pt;\" width=\"180\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eCD20+, CD79\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: Symbol;\"\u003ea\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e+, PAX5+, CD30+, MUM1+, ALK-1-, CD10-CD43-, cyclinD1-, CD3-, LMP1+, EBNA2+, EBER+. Ig clonality +.\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 79.0pt; border: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 23.7pt;\" width=\"105\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eCT/BM staging: neg\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; Surgery only\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 23.7pt;\" width=\"104\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eNED at 42 mo\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 23.7pt;\"\u003e\n\u003ctd style=\"width: 72.6pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 23.7pt;\" width=\"97\"\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eAtrial myxoma\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e \u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eTapan\u0026nbsp; 2015 (ref 8)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 23.7pt;\" width=\"47\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e49/M\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 62.1pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 23.7pt;\" width=\"83\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003enegative\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 23.7pt;\" width=\"132\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003ePalpitations\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 23.7pt;\" width=\"123\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eFoci of large lymphoid cells\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 134.65pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 23.7pt;\" width=\"180\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eCD20+, CD79\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: Symbol;\"\u003ea\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e+, CD30+, MUM1+, CD3-, CD5-, CD10-, CD138-, cyclin D1-, ALK1-, EMA-. Ki67 80%. EBNA2+, EBER+. Ig clonality NP.\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 79.0pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 23.7pt;\" width=\"105\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eNS Staging: neg\u0026nbsp; BM neg\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; Surgery +\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; R-CHOP\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: solid black 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt; height: 23.7pt;\" width=\"104\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eNED at 12 mo\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 96.55pt;\"\u003e\n\u003ctd style=\"width: 72.6pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 96.55pt;\" width=\"97\"\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eAtrial myxoma\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e \u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eBoyer 2017 (ref 9)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 96.55pt;\" width=\"47\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e54/F\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 62.1pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 96.55pt;\" width=\"83\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003enegative\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 96.55pt;\" width=\"132\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eSyncope\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 96.55pt;\" width=\"123\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eFoci of large lymphoid cells\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 134.65pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 96.55pt;\" width=\"180\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eCD20+, PAX5+, CD79\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: Symbol;\"\u003ea\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e+, BCL6+, CD30+, CD10-, CD138- CD3-, HHV8-, Ki67 80%. EBER+. Ig clonality NP.\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 79.0pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 96.55pt;\" width=\"105\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eNS Staging: neg\u0026nbsp; Surgery\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; Other therapy: NA\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: solid black 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt; height: 96.55pt;\" width=\"104\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eNED at 130 mo\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 96.55pt;\"\u003e\n\u003ctd style=\"width: 72.6pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 96.55pt;\" width=\"97\"\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eAtrial myxoma\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e \u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eBoyer\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 2017\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; (ref 9)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 96.55pt;\" width=\"47\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e55/F\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 62.1pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 96.55pt;\" width=\"83\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003enegative\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 96.55pt;\" width=\"132\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eSyncope, cough, dyspnea\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 96.55pt;\" width=\"123\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eFoci of large lymphoid cells\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 134.65pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 96.55pt;\" width=\"180\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eCD20+, PAX5+, CD79\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: Symbol;\"\u003ea\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e+, BCL6+, MUM1+, CD10-, CD45+, CD30+, HHV-8-, CD138-, CD3-. Ki67: \u0026gt;95%. EBER+, LMP1+, EBNA2+. FISH for MYC-. Ig clonality NP.\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 79.0pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 96.55pt;\" width=\"105\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eNS Staging: neg\u0026nbsp;\u0026nbsp; Surgery only\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: solid black 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt; height: 96.55pt;\" width=\"104\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eDied at 2 mo for cardiac cause. Autopsy: No lymphoma \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 96.55pt;\"\u003e\n\u003ctd style=\"width: 72.6pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 96.55pt;\" width=\"97\"\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eAtrial\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e \u003cstrong\u003emyxoma\u003c/strong\u003e\u003c/span\u003e\u003c/em\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e Boyer 2017 (ref 9)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 96.55pt;\" width=\"47\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e54/M\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 62.1pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 96.55pt;\" width=\"83\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003enegative\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 96.55pt;\" width=\"132\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eDyspnea, respiratory failure\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 96.55pt;\" width=\"123\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eFoci of large lymphoid cells\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 134.65pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 96.55pt;\" width=\"180\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eCD20+, PAX5+, BCL6+, MUM1+, CD10-, CD38+, CD45+, CD30+, CD3-. Ki67:90% EBER+, LMP1+, EBNA2+.\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;FISH MYC, BCL6, BCL2 -. Ig clonality NP.\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 79.0pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 96.55pt;\" width=\"105\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eCT/BM Staging: neg\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; Surgery only\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: solid black 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt; height: 96.55pt;\" width=\"104\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eRecurrent FA-DLBCL at mitral valve after 25 mo. Died at 26 mo (embolic stroke). No autopsy.\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"text-align: justify;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: justify;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"margin-left: -2.2pt; border-collapse: collapse;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 46.25pt;\"\u003e\n\u003ctd style=\"width: 72.6pt; border: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 46.25pt;\" width=\"97\"\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eAtrial myxoma \u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eYan 2017\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; (ref 9)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; border: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 46.25pt;\" width=\"47\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e54/M\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 62.1pt; border: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 46.25pt;\" width=\"83\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003enegative\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; border: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 46.25pt;\" width=\"132\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eCongestive heart failure\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 46.25pt;\" width=\"123\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eFoci of large lymphoid cells within fibrin\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 134.65pt; border: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 46.25pt;\" width=\"180\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eCD20+, CD79\u0026alpha;+, MUM1+, CD10-, BCL6+, CD30+. ALK-, BCL2+, CD3-, CD5-, Ki67 90% LMP1+, EBNA-2+, EBER+,\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; FISH for MYC, Bcl6, BCL2-. Ig clonality NP.\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 79.0pt; border: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 46.25pt;\" width=\"105\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eCT/BM Staging: neg\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; Surgery only\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 46.25pt;\" width=\"104\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eNED at 7 MO\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 46.25pt;\"\u003e\n\u003ctd style=\"width: 72.6pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 46.25pt;\" width=\"97\"\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eAtrial myxoma\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e \u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eYan 2017\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; (ref 10)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 46.25pt;\" width=\"47\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e61/F\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 62.1pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 46.25pt;\" width=\"83\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003enegative\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 46.25pt;\" width=\"132\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eCongestive heart failure\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 46.25pt;\" width=\"123\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eFoci of large lymphoid cells within fibrin\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 134.65pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 46.25pt;\" width=\"180\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eCD20+, CD79\u0026alpha;+, MUM1+, CD10+, BCL6+, CD30+. ALK-, BCL2+, CD3-, CD5-, Ki67 95% LMP1+, EBNA-2+, EBER+,\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; FISH for MYC, Bcl6, BCL2-. Ig clonality NP.\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 79.0pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 46.25pt;\" width=\"105\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eCT/BM Staging: neg\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; Surgery only\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: solid black 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt; height: 46.25pt;\" width=\"104\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eNED at 84 mo\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 46.25pt;\"\u003e\n\u003ctd style=\"width: 72.6pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 46.25pt;\" width=\"97\"\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eAtrial myxoma \u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eYan 2017\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; (ref 10)\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 46.25pt;\" width=\"47\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e46/F\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 62.1pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 46.25pt;\" width=\"83\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003enegative\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 46.25pt;\" width=\"132\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eCongestive heart failure\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 46.25pt;\" width=\"123\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eFoci of large lymphoid cells within fibrin\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 134.65pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 46.25pt;\" width=\"180\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eCD20+, CD79\u0026alpha;+, MUM1+, CD10-, BCL6+, CD30+. ALK-, BCL2+, CD3-, CD5-, Ki67 90% LMP1+, EBNA-2+, EBER+,\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; FISH for MYC, Bcl6, BCL2-. Ig clonality NP.\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 79.0pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 46.25pt;\" width=\"105\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eCT/BM Staging: neg.\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; Surgery only\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: solid black 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt; height: 46.25pt;\" width=\"104\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eNED at 3 mo\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 62.75pt;\"\u003e\n\u003ctd style=\"width: 72.6pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 62.75pt;\" width=\"97\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003eAtrial myxoma \u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003eYan 2017\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; (ref 10)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 62.75pt;\" width=\"47\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e46/F\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 62.1pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 62.75pt;\" width=\"83\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003enegative\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 62.75pt;\" width=\"132\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003eCongestive heart failure\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 62.75pt;\" width=\"123\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003eFoci of large lymphoid cells within fibrin\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 134.65pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 62.75pt;\" width=\"180\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003eCD20+, CD79\u0026alpha;+, MUM1+, CD10-, BCL6-, CD30+. ALK-, BCL2-, CD3-, CD5-, Ki67 85% LMP1+, EBNA-2+, EBER+,\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; FISH for MYC, Bcl6, BCL2-. Ig clonality NP.\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 79.0pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 62.75pt;\" width=\"105\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003eCT/BM Staging: neg.\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; Surgery only\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: solid black 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt; height: 62.75pt;\" width=\"104\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003eNED at 120 mo\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 72.6pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"97\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003eAtrial thrombus \u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003eQigley 2003 (ref 11) \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"47\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e29/M\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 62.1pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"83\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003enegative\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"132\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003eCerebral embolic stroke \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"123\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003eFoci of large lymphoid cells at clot\u0026rsquo;s surface\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 134.65pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"180\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003eCD45+, CD20+, CD79\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: Symbol;\"\u003ea\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e+\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e, CD43+, CD30+, CD3, LMP -, HHV8-, EBER+.\u0026nbsp; \u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;Clonality:\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: Symbol;\"\u003ek\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e rearrangement +. IGH -, TCR-.\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 79.0pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"105\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003eImaging/BM Staging: neg\u0026nbsp;\u0026nbsp;\u0026nbsp; Surgery+\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u0026nbsp;\u0026nbsp;\u0026nbsp;R-CHOP (VI)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: solid black 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"104\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003eNED at 24 mo\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"text-align: justify;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: justify;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: justify;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"margin-left: -2.2pt; border-collapse: collapse;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 101.15pt;\"\u003e\n\u003ctd style=\"width: 1.7pt; padding: 0in 5.4pt 0in 5.4pt; height: 101.15pt;\" width=\"2\"\u003e\n\u003cp style=\"layout-grid-mode: char;\"\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; border: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 101.15pt;\" width=\"95\"\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eAtrial thrombus\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e \u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eGruver 2012 (ref 12)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; border: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 101.15pt;\" width=\"47\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e56/M\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 62.1pt; border: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 101.15pt;\" width=\"83\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003enegative\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; border: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 101.15pt;\" width=\"132\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eshort breath\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 101.15pt;\" width=\"123\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eFoci of large lymphoid cells within fibrin thrombus\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 134.65pt; border: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 101.15pt;\" width=\"180\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eCD20+, CD79\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: Symbol;\"\u003ea\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e+, PAX5+, CD30+, CD43-, CD45+, BCL6+, MUM1+, BCL2+, CD10-, CD3-, CD5-, HHV8-, MYC+30%;\u0026nbsp; KI67 \u0026gt;90% LMP1+, EBNA2+.EBER+. Ig clonality +.\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.4pt; border: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 101.15pt;\" width=\"103\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eNS Staging: neg\u0026nbsp; Surgery+\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; R-CHOP (VI)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 79.55pt; border: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 101.15pt;\" colspan=\"2\" width=\"106\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eNED at 8 mo\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 95.55pt;\"\u003e\n\u003ctd style=\"width: 1.7pt; padding: 0in 5.4pt 0in 5.4pt; height: 95.55pt;\" width=\"2\"\u003e\n\u003cp style=\"layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 95.55pt;\" width=\"95\"\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eMyxomatous mitral valve\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e \u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eGruver\u0026nbsp; 2012\u0026nbsp;\u0026nbsp; (ref 12)\u0026nbsp;\u0026nbsp; \u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 95.55pt;\" width=\"47\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e75/M\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 62.1pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 95.55pt;\" width=\"83\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003enegative\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 95.55pt;\" width=\"132\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eDyspnea, aortic insufficiency, mitral valve regurgitation\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 95.55pt;\" width=\"123\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eFoci of large lymphoid cells within fibrin on mitral valve\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 134.65pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 95.55pt;\" width=\"180\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003eCD20+, CD79\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: Symbol;\"\u003ea\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e+, PAX5+, CD30-, CD43-, CD45+, BCL6-, MUM1+, BCL2+, CD10-, CD3-, CD5-, HHV8-, MYC -. KI67100%.\u0026nbsp; \u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;LMP1-, EBNA2-. EBER-.\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; Ig clonality +.\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.4pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 95.55pt;\" width=\"103\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eNS Staging: neg Surgery+R-CVP (I) +R-CHOP (VI) \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 79.55pt; border: solid black 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt; height: 95.55pt;\" colspan=\"2\" width=\"106\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eNED at 39 mo\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 71.1pt;\"\u003e\n\u003ctd style=\"width: 72.6pt; border: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 71.1pt;\" colspan=\"2\" width=\"97\"\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eProsthesis \u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e(knee) \u003c/span\u003e\u003c/em\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eCheuk 2005\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; (ref 13)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 71.1pt;\" width=\"47\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e78/M\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 62.1pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 71.1pt;\" width=\"83\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003enegative\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 71.1pt;\" width=\"132\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003ePain at \u003cem\u003eknee prosthesis\u003c/em\u003e (implanted 22 yrs before)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 71.1pt;\" width=\"123\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eFoci of large lymphoid cells within fibrin and necrosis\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 134.65pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 71.1pt;\" width=\"180\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003eCD20+, CD79\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: Symbol;\"\u003ea\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e+, CD138+/-. CD2-, CD3-, CD5-, CD10- , BCL6-, HHV8-. Ki67:70%.\u0026nbsp; LMP1+, EBER+. Ig clonality +.\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 79.0pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 71.1pt;\" colspan=\"2\" width=\"105\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eNS Staging: neg\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; Surgery+RT\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: solid black 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt; height: 71.1pt;\" width=\"104\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eNED at 24 mo\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 66.95pt;\"\u003e\n\u003ctd style=\"width: 72.6pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 66.95pt;\" colspan=\"2\" width=\"97\"\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eProsthesis\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e (Aortic valve) \u003c/span\u003e\u003c/em\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eBagwan 2009 (ref 2)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 66.95pt;\" width=\"47\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e50/M\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 62.1pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 66.95pt;\" width=\"83\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003enegative\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 66.95pt;\" width=\"132\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eSymptoms of aortic regurgitation. \u003cem\u003eAortic valve prosthesis\u003c/em\u003e (16yrs before)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 66.95pt;\" width=\"123\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eFoci of large lymphoid cells within aortic valve leaflets \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 134.65pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 66.95pt;\" width=\"180\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eCD45+, CD20+, CD79\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: Symbol;\"\u003ea\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e+, CD10+, BC6+/-, BCL2+/-, \u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eKi67:80%\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u0026nbsp; \u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eLMP1-.\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; Ig clonality: NP.\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 79.0pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 66.95pt;\" colspan=\"2\" width=\"105\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eNS Staging: neg\u0026nbsp; \u0026nbsp;\u0026nbsp;\u0026nbsp;BM: neg\u0026nbsp; Surgery+\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; R-CHOP\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: solid black 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt; height: 66.95pt;\" width=\"104\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003eDied after 6mo for prosthesis rupture. Autopsy: no lymphoma\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 90.9pt;\"\u003e\n\u003ctd style=\"width: 1.7pt; padding: 0in 5.4pt 0in 5.4pt; height: 90.9pt;\" width=\"2\"\u003e\n\u003cp style=\"layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 90.9pt;\" width=\"95\"\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eProsthesis\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e \u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e(aortic valve) Berrio 2010 (ref 14)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 90.9pt;\" width=\"47\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e60/M\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 62.1pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 90.9pt;\" width=\"83\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003enegative\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 90.9pt;\" width=\"132\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eAcute left heart failure. History of \u003cem\u003eaortic valve prosthesis\u0026nbsp; \u003c/em\u003efor\u0026nbsp; stenosis\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 90.9pt;\" width=\"123\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eFoci of large lymphoid cells within valve vegetations\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 134.65pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 90.9pt;\" width=\"180\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eCD20+, CD43+, CD3-.\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; Ki67:80-90%\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; EBV: NV. Ig clonality: NP.\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 79.0pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 90.9pt;\" colspan=\"2\" width=\"105\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eNS Staging: neg Surgery only\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: solid black 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt; height: 90.9pt;\" width=\"104\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eDied for tricuspidal endocarditis, pneumonia 2yrs later.\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; No autopsy.\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"border: none;\" width=\"15\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"88\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"44\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"66\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"100\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"89\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"132\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"87\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"1\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"89\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"text-align: justify;\"\u003e\u0026nbsp;\u003c/p\u003e\n\u003ctable style=\"margin-left: -2.2pt; border-collapse: collapse;\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 72.6pt; border: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"97\"\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eProsthesis\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e \u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e(aortic graft) Miller 2010 (ref 15)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; border: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"47\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e48/M\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 62.1pt; border: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"83\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003enegative\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; border: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"132\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eIschemic attack. Marfan sy. Asc.a. aneurysm graft+ aortic valve prosthesis (24 yrs before)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"123\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eFoci of large lymphoid cells within fibrin\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 134.65pt; border: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"180\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eCD20+, MUM1+, CD10-, BCL6- BCL2+, CD3-, HHV8-. EBER+. Ig clonality +.\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 79.0pt; border: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"105\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eCT/PET/BM Staging: neg Surgery only\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"104\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eNED at 6 mo\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 72.6pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"97\"\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eProsthesis\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e \u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e(aortic valve) Miller 2010 (ref 15)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"47\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e80/F\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 62.1pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"83\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003enegative\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"132\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eHeart failure. Aortic valve prosthesis (8 yrs before)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"123\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eFoci of large lymphoid cells within fibrin\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 134.65pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"180\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eCD20+, MUM1+, CD10-, BCL6-BCL2-, CD3-, HHV8-, EBER+. Ig clonality +.\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 79.0pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"105\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eCT/PET/BM Staging: neg\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; Surgery only\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: solid black 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"104\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eDied (for breast cancer 18 mo after aortic valve surgery). No autopsy.\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 62.75pt;\"\u003e\n\u003ctd style=\"width: 72.6pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 62.75pt;\" width=\"97\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003eProsthesis\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e \u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e(aortic graft) Miller 2010 (ref 15)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 62.75pt;\" width=\"47\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e79/F\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 62.1pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 62.75pt;\" width=\"83\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003enegative\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 62.75pt;\" width=\"132\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003eShort breath, thoracic pulsing sensation. Tube graft for asc. a. dissection (5 yrs before)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 62.75pt;\" width=\"123\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003eFoci of large lymphoid cells within fibrin\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 134.65pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 62.75pt;\" width=\"180\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003eCD20+, MUM1+, CD10-, BCL6+, BCL2+, CD3-, HHV8-, EBER+, Ig clonality +.\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 79.0pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 62.75pt;\" colspan=\"2\" width=\"105\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003eCT/PET/BM Staging: neg\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; Surgery only\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: solid black 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt; height: 62.75pt;\" width=\"104\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003eDied for surgical complications. No autopsy\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 72.6pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"97\"\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eProsthesis \u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e(aortic graft) Gruver 2012 (ref 12)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"47\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e55/M\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 62.1pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"83\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003enegative\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"132\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eStroke. Aortic graft for aneurysm (4 yrs before)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"123\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eFoci of large lymphoid cells within thrombus\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 134.65pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"180\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eCD20+, CD79\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: Symbol;\"\u003ea\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e+, PAX5+, CD30+, CD43+, CD45+, BCL6+, MUM1+, BCL2-, CD10-, CD3-, CD5-, HHV8-, MYC-; KI67 100%. LMP1+, EBNA2+.EBER+. Ig clonality +.\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.4pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"103\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eNS Staging: neg\u0026nbsp;\u0026nbsp; Surgery +\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; R-CEOP (VIII)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 79.55pt; border: solid black 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"106\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eNED at 16 mo\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 72.6pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"97\"\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eProsthesis \u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e(vascular graft)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; Boyer 2017 (ref 9)\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"47\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e56/M\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 62.1pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"83\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003enegative\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"132\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eIR aorta+ CIA aneurysms. TAA aneurysm graft + thrombectomy (1 yr before). Asc a. dissection graft\u0026nbsp; (9 yrs before).\u0026nbsp; \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"123\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eFoci of large lymphoid cells within thrombus of IR aorta and CIA\u0026nbsp; aneurysms. In retrospect\u0026nbsp; foci within thrombus of TAA aneurysm\u0026nbsp; \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 134.65pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"180\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eCD20+, PAX5+, BCL6-, MUM1+, CD10-, CD138-, HHV8-, CD30+, KI67: 95%. EBER+, LMP1+, EBNA2+. FISH for MYC -. Ig clonality +.\u0026nbsp;\u0026nbsp; \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.4pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"103\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eCT/PET/BM Staging: neg Surgery+\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; R-CHOP (VI) +\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; IT MTX\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 79.55pt; border: solid black 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"106\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eAWSD at 24 mo. Surgical revision of aortic graft: persistent foci of EBV+ large B cell.\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"border: none;\" width=\"79\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"45\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"67\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"106\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"91\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"135\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"90\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"1\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"96\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"text-align: justify;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: justify;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"margin-left: -2.2pt; border-collapse: collapse;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 46.25pt;\"\u003e\n\u003ctd style=\"width: 72.6pt; border: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 46.25pt;\" width=\"97\"\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eProsthesis\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e (vascular graft)\u003c/span\u003e\u003c/em\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; Boyer 2017 (ref 9)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; border: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 46.25pt;\" width=\"47\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e68/M\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 62.1pt; border: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 46.25pt;\" width=\"83\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003enegative\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; border: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 46.25pt;\" width=\"132\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eLower limbs ischemia.\u0026nbsp; AA aneurysm repair with IR graft (7 yrs before). \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 46.25pt;\" width=\"123\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eFoci of large lymphoid cells within thrombus \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 134.65pt; border: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 46.25pt;\" width=\"180\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eCD20+, PAX5+, BCL6+, CD10-MUM1+, CD30+, HHV8-, KI67 90%, EBER+, LMP1+, EBNA2+.\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; FISH for MYC -. Ig clonality NP.\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 79.0pt; border: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 46.25pt;\" width=\"105\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eCT/PET Staging neg. 3 mo after: PET/CT/biopsy:\u0026nbsp; foci of EBV+ cells near adrenal gland.\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; R-COEP (II) \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 46.25pt;\" width=\"104\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eDied at 10 mo for embolic stroke. \u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eNo progressive lymphoma.\u0026nbsp;\u0026nbsp;\u0026nbsp; No autopsy\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 103.95pt;\"\u003e\n\u003ctd style=\"width: 72.6pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 103.95pt;\" width=\"97\"\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eProsthesis \u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e(vascular)\u003c/span\u003e\u003c/em\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e Boyer 2017\u0026nbsp;\u0026nbsp; (ref 9)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 103.95pt;\" width=\"47\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e71/M\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 62.1pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 103.95pt;\" width=\"83\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eMG for THY treated with surgery+ steroids+ AZA \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 103.95pt;\" width=\"132\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eAF graft (6 yrs before). \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 103.95pt;\" width=\"123\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eFoci of large lymphoid cells within thrombus associated with graft\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 134.65pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 103.95pt;\" width=\"180\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eCD20+, CD79\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: Symbol;\"\u003ea\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e+, PAX5+, CD10-BCL6+, MUM1+, CD30+, CD45+, CD138-, HHV8-, KI67\u0026gt;95%, EBER+, LMP1+. Ig clonality +.\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 79.0pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 103.95pt;\" width=\"105\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eNS Staging: neg\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; Surgery only\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: solid black 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt; height: 103.95pt;\" width=\"104\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eNED at 10 mo\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 28.05pt;\"\u003e\n\u003ctd style=\"width: 72.6pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 28.05pt;\" width=\"97\"\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003ePseudocyst \u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e(kidney)\u003cem\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u003c/em\u003eLee\u0026nbsp;\u0026nbsp; 2009\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; (ref 16)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 28.05pt;\" width=\"47\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e61/M\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 62.1pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 28.05pt;\" width=\"83\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003enegative\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 28.05pt;\" width=\"132\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eRenal cyst (for 20 yrs)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 28.05pt;\" width=\"123\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eFoci of large lymphoid cells within necrosis\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 134.65pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 28.05pt;\" width=\"180\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eCD22+, CD45+, CD79\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: Symbol;\"\u003ea\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e+, MUM1+, PAX5+, CD3-, CD10-, CD20-, CD138-, BCL6-, ALK1-, HHV8-, \u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: Symbol;\"\u003ek\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e-, \u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: Symbol;\"\u003el\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e-, EBER+. Ig clonality NP.\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 79.0pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 28.05pt;\" width=\"105\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eStaging NA\u0026nbsp;\u0026nbsp; Surgery+\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; CHOP (VI)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: solid black 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt; height: 28.05pt;\" width=\"104\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eNA\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 72.6pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"97\"\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003ePseudocyst\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e \u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e(spleen)\u0026nbsp;\u0026nbsp; \u003cem\u003e\u0026nbsp;\u003c/em\u003eLoong 2010\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; (ref 4)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"47\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e29/M\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 62.1pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"83\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003enegative\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"132\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eAbdominal pain\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"123\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eFoci of large lymphoid cells within necrosis\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 134.65pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"180\"\u003e\n\u003cp style=\"margin-right: -5.2pt;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eCD20+, CD79\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: Symbol;\"\u003ea\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e+, PAX5+, CD43+, MUM1+, CD10-, BCL6-CD138-, BCL2+, CD30-, HHV8-, CD3-. Ki67 90%.\u0026nbsp; LMP1+, EBNA2+, EBER+. Ig clonality +.\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 79.0pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"105\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003ePET/BM Staging: neg\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; Surgery (splenectomy)+ R (IV)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: solid black 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"104\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eNED at 6 mo\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 62.75pt;\"\u003e\n\u003ctd style=\"width: 72.6pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 62.75pt;\" width=\"97\"\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003ePseudocyst \u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e(kidney)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; Valli\u0026nbsp; 2011\u0026nbsp;\u0026nbsp; (ref 17)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 62.75pt;\" width=\"47\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e46/M\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 62.1pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 62.75pt;\" width=\"83\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003enegative\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 62.75pt;\" width=\"132\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eLeft-sided flank pain\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 62.75pt;\" width=\"123\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eFoci of large lymphoid cells within necrosis\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 134.65pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 62.75pt;\" width=\"180\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eCD20+, MUM1+, CD10-, BCL6-BCL2+, CD30-, HHV8-;Ki67:90%. EBER+. Ig clonality NP.\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 79.0pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 62.75pt;\" width=\"105\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eCT/PET/BM Staging: neg\u0026nbsp;\u0026nbsp; Surgery+\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; R-CHOP (VI)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: solid black 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt; height: 62.75pt;\" width=\"104\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eNED at 1 mo\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"text-align: justify;\"\u003e\u0026nbsp;\u003c/p\u003e\n\u003ctable style=\"margin-left: -2.2pt; border-collapse: collapse;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 86.5pt;\"\u003e\n\u003ctd style=\"width: 72.6pt; border: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 86.5pt;\" width=\"97\"\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003ePseudocyst\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e \u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e(adrenal gland) Boroumand\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 2012\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; (ref 18)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; border: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 86.5pt;\" width=\"47\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e63/F\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 62.1pt; border: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 86.5pt;\" width=\"83\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003enegative\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; border: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 86.5pt;\" width=\"132\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eRight abdominal pain\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 86.5pt;\" width=\"123\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eFoci of large lymphoid cells within fibrin\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 134.65pt; border: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 86.5pt;\" width=\"180\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eCD20+, CD79\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: Symbol;\"\u003ea\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e+, PAX5+, MUM1+, BCL2+, CD3-, CD10-, CD30- , BCL6-, HHV8-. Ki67 \u0026gt;90%.\u0026nbsp; LMP1-; EBER+. Ig clonality NP.\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 79.0pt; border: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 86.5pt;\" width=\"105\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eNS Staging: neg\u0026nbsp;\u0026nbsp;\u0026nbsp; Surgery +\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;R-CHOP (VI)+RT\u0026nbsp;\u0026nbsp;\u0026nbsp; \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 86.5pt;\" width=\"104\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eNED at 40 mo\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 26.65pt;\"\u003e\n\u003ctd style=\"width: 72.6pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 26.65pt;\" width=\"97\"\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003ePseudocyst\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e \u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e(testis) Boroumand\u0026nbsp; 2012\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; (ref 18)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 26.65pt;\" width=\"47\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e27/M\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 62.1pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 26.65pt;\" width=\"83\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003enegative\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 26.65pt;\" width=\"132\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eR. scrotal swelling. Herniorraphy followed by l. scrotal hematoma (removed 3 yrs before)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 26.65pt;\" width=\"123\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eFoci of large lymphoid cells within fibrin\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 134.65pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 26.65pt;\" width=\"180\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eCD20+, CD79\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: Symbol;\"\u003ea\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e+, CD30+, MUM1+, BCL2+, CD3-, CD10- BCL6-, HHV8-. Ki67\u0026gt;90%.\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; LMP1+, EBER+. Ig clonality NP.\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 79.0pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 26.65pt;\" width=\"105\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eNS Staging: neg\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; Surgery only \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: solid black 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt; height: 26.65pt;\" width=\"104\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eNED at 9 mo\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 46.25pt;\"\u003e\n\u003ctd style=\"width: 72.6pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 46.25pt;\" width=\"97\"\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003ePseudocyst \u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e(spleen)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; Boyer\u0026nbsp; 2017 (ref 9)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 46.25pt;\" width=\"47\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e37/F\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 62.1pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 46.25pt;\" width=\"83\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003enegative\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 46.25pt;\" width=\"132\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eSplenic mass (9 cm), incidentally found\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 46.25pt;\" width=\"123\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eFoci of large lymphoid cells within fibrin\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 134.65pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 46.25pt;\" width=\"180\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eCD20+, PAX5+, MUM1+, CD10-BCL6-, CD30-, CD45+, KI67\u0026gt;90% EBER+.\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; Ig clonality NP.\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 79.0pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 46.25pt;\" width=\"105\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eCT/PET/BM Staging: neg.\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; Surgery +\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; R-CHOP (III)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: solid black 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt; height: 46.25pt;\" width=\"104\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eNED at 32 mo\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 46.25pt;\"\u003e\n\u003ctd style=\"width: 72.6pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 46.25pt;\" width=\"97\"\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003ePseudocyst \u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e(retrop.)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u003c/span\u003e\u003c/em\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eBoyer\u0026nbsp; 2017 (ref 9)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 46.25pt;\" width=\"47\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e73/M\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 62.1pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 46.25pt;\" width=\"83\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003enegative\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 46.25pt;\" width=\"132\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eFemoral a. aneurysm repair \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 46.25pt;\" width=\"123\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eFoci of large lymphoid cells within fibrin\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 134.65pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 46.25pt;\" width=\"180\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eCD20+, PAX5+, CD79\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: Symbol;\"\u003ea\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e+, BCL6-, CD10-, MUM1+, CD30+, CD45+, HHV8-, KI67\u0026gt;95%, EBER+. Ig clonality NP.\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 79.0pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 46.25pt;\" width=\"105\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eCT/BM Staging: neg\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; Surgery+ R-CHOP (VI)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: solid black 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt; height: 46.25pt;\" width=\"104\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eNED at 43 mo\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 46.25pt;\"\u003e\n\u003ctd style=\"width: 72.6pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 46.25pt;\" width=\"97\"\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003ePseudocyst \u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e(adrenal gland)\u0026nbsp; Boyer\u0026nbsp; 2017\u0026nbsp; (ref 9)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 46.25pt;\" width=\"47\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e70/M\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 62.1pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 46.25pt;\" width=\"83\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003enegative\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 46.25pt;\" width=\"132\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eAdrenal mass (7 cm) causing bladder obstruction\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 46.25pt;\" width=\"123\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eFoci of large lymphoid cells within fibrin\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 134.65pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 46.25pt;\" width=\"180\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eCD20-, PAX5+, CD79\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: Symbol;\"\u003ea\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e+, BCL6-, CD10-, MUM1+, CD45+, CD30+, CD138-, HHV8-, KI67\u0026gt;90%, LMP1-, EBNA2+, EBER+. FISH for MYC -. Ig clonality NP.\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 79.0pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 46.25pt;\" width=\"105\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eCT/PET Staging: neg\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; Surgery only\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: solid black 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt; height: 46.25pt;\" width=\"104\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eNED at 14 mo\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 46.25pt;\"\u003e\n\u003ctd style=\"width: 72.6pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 46.25pt;\" width=\"97\"\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003ePseudocyst \u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e(retrop.)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; Boyer\u0026nbsp; 2017 (ref 9)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 46.25pt;\" width=\"47\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e44/M\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 62.1pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 46.25pt;\" width=\"83\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003enegative\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 46.25pt;\" width=\"132\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eRight flank pain \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 46.25pt;\" width=\"123\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eFoci of large lymphoid cells within fibrin\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 134.65pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 46.25pt;\" width=\"180\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eCD20+, PAX5+, CD10-, BCL6-, MUM1+, CD45+, CD30-, KI67 40%, LMP1+, EBNA2+, EBER+, FISH for MYC -. Ig clonality +.\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 79.0pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 46.25pt;\" width=\"105\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eBM/imaging Staging: neg\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 5-CHOP\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: solid black 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt; height: 46.25pt;\" width=\"104\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eNED at 84 mo\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"text-align: justify;\"\u003e\u0026nbsp;\u003c/p\u003e\n\u003ctable style=\"margin-left: -2.2pt; border-collapse: collapse;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 62.05pt;\"\u003e\n\u003ctd style=\"width: 72.6pt; border: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 62.05pt;\" width=\"97\"\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003ePseudocyst \u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e(adrenal gland) Zanelli \u0026nbsp;2019 (ref 19)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; border: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 62.05pt;\" width=\"47\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e71/F\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 62.1pt; border: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 62.05pt;\" width=\"83\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003enegative\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; border: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 62.05pt;\" width=\"132\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eLower limbs edema+\u0026nbsp;\u0026nbsp; abdominal distension\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 62.05pt;\" width=\"123\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eFoci of large lymphoid cells within fibrin\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 134.65pt; border: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 62.05pt;\" width=\"180\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eCD20+, PAX5+, CD30+, MUM1+, CD10-, BCL6-, EBER+, Ki67 90%.\u0026nbsp; Ig clonality NP.\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 79.0pt; border: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 62.05pt;\" width=\"105\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eCT Staging: neg\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; Surgery only\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 62.05pt;\" width=\"104\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eNED at 6 mo\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 26.65pt;\"\u003e\n\u003ctd style=\"width: 72.6pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 26.65pt;\" width=\"97\"\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eTeratoma \u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e(ovary)\u0026nbsp;\u0026nbsp;\u0026nbsp; \u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;Valli\u0026nbsp; 2014\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e(ref 20)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 26.65pt;\" width=\"47\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e56/F\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 62.1pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 26.65pt;\" width=\"83\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003enegative\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 26.65pt;\" width=\"132\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eAbdominal pain+ swelling\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 26.65pt;\" width=\"123\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eFoci of large lymphoid cells\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 134.65pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 26.65pt;\" width=\"180\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eCD20+, MUM1+, CD45+, PAX5+, CD30-, BCL6-, CD10-, CD3-, CD2-, HHV8-, CD138-. Ki67: 80%. EBER+. Ig clonality +.\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 79.0pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 26.65pt;\" width=\"105\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eCT/PET Staging: neg\u0026nbsp; Surgery+ R-CHOP (VI)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: solid black 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt; height: 26.65pt;\" width=\"104\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eNED at 8 mo\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 72.6pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"97\"\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eHydrocele\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e \u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e(testis)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; Loong 2010\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; (ref 4)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"47\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e88/M\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 62.1pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"83\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003enegative\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"132\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eFever, scrotal pain, swelling\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"123\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eFoci of large lymphoid cells within necrosis\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 134.65pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"180\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eCD20+, CD79\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: Symbol;\"\u003ea\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e+, PAX5+, MUM1+, CD10-, BCL6-, CD138-, BCL2+, CD30-, HHV8-, CD3+, CD2-, CD5-, CD7-. Ki67 70% LMP1+, EBNA2+, EBER+. Ig clonality -.\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 79.0pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"105\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eStaging NA Surgery only (Orchidectomy)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: solid black 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"104\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eNA\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 103.95pt;\"\u003e\n\u003ctd style=\"width: 72.6pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 103.95pt;\" width=\"97\"\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eHematoma \u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e(testis)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; Boyer\u0026nbsp; 2017 (ref 9)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 103.95pt;\" width=\"47\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e79/M\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 62.1pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 103.95pt;\" width=\"83\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003enegative\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 103.95pt;\" width=\"132\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eTesticular trauma (5 yrs before)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 103.95pt;\" width=\"123\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eFoci of large lymphoid cells within hematoma\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 134.65pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 103.95pt;\" width=\"180\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eCD20+, PAX5+, CD79\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: Symbol;\"\u003ea\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e+, CD10-CD138-, BCL6-, MUM1+, CD45+, CD30+, HHV8-, KI67 \u0026gt; 90%, EBER+, LMP1+, EBNA2+.\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; Ig clonality +.\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 79.0pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 103.95pt;\" width=\"105\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eNS Staging: neg.\u0026nbsp;\u0026nbsp; Surgery only\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: solid black 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt; height: 103.95pt;\" width=\"104\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eNED.\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; Died at 17 mo\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 26.65pt;\"\u003e\n\u003ctd style=\"width: 72.6pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 26.65pt;\" width=\"97\"\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eHematoma \u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e(thigh)\u003cstrong\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u003c/strong\u003e\u003c/span\u003e\u003c/em\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eHayes\u0026nbsp;\u0026nbsp;\u0026nbsp; 2014 (ref 21)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 26.65pt;\" width=\"47\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e91/M\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 62.1pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 26.65pt;\" width=\"83\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003enegative\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 26.65pt;\" width=\"132\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eThigh hematoma. (6 yrs before leg amputation for popl. a. aneurysm rupture at prior artery bypass graft site)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 26.65pt;\" width=\"123\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eFoci of large lymphoid cells\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 134.65pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 26.65pt;\" width=\"180\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eCD45+, CD20+, MUM1+, CD30+, CD43+, BCL2+/-, MYC+, p53+/-, HHV8-, CD3-, CD5-, CD10-, BCL1-, BCL6-. Ki67: 90%. LMP1-, EBER+.\u0026nbsp; Ig clonality NP.\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 79.0pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 26.65pt;\" width=\"105\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eNS Staging: neg\u0026nbsp; \u0026nbsp;\u0026nbsp;Surgery only. \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: solid black 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt; height: 26.65pt;\" width=\"104\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eNED at 18 mo\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003ctable style=\"margin-left: -2.2pt; border-collapse: collapse;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 62.75pt;\"\u003e\n\u003ctd style=\"width: 70.9pt; border: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 62.75pt;\" width=\"95\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003eSubdural hematoma \u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003eReyes 1990 (ref 22)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; border: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 62.75pt;\" width=\"47\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e56/M\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 79.65pt; border: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 62.75pt;\" width=\"106\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003enegative\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 83.35pt; border: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 62.75pt;\" width=\"111\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003eHeadaches, dizziness, unsteady gait \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; border: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 62.75pt;\" width=\"113\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003eFoci of large lymphoid cells within fibrin, clots, necrosis\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 127.6pt; border: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 62.75pt;\" width=\"170\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003eB-cell phenotype. EBV NV. Ig clonality NP.\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.95pt; border: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 62.75pt;\" width=\"124\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003eCT/BM Staging: neg\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;Surgery only\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.95pt; border: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 62.75pt;\" width=\"105\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003eNA\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 26.65pt;\"\u003e\n\u003ctd style=\"width: 70.9pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 26.65pt;\" width=\"95\"\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eSubdural hematoma\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e \u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eSugita\u0026nbsp;\u0026nbsp; 2012 (ref 23)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 26.65pt;\" width=\"47\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e77/M\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 79.65pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 26.65pt;\" width=\"106\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003enegative\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 83.35pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 26.65pt;\" width=\"111\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eDementia due to head trauma (20 yrs before)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 26.65pt;\" width=\"113\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eFoci of large lymphoid cells\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 127.6pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 26.65pt;\" width=\"170\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eCD20+, CD79\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: Symbol;\"\u003ea\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e+, MUM1+, CD3-, BCL6-, CD10-. Ki67 high. EBNA2+, LMP1-, EBER+. Ig clonality - (rare neoplastic foci).\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.95pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 26.65pt;\" width=\"124\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eImaging Staging: neg\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; Surgery only\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.95pt; border: solid black 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt; height: 26.65pt;\" width=\"105\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eNA\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 23.7pt;\"\u003e\n\u003ctd style=\"width: 70.9pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 23.7pt;\" width=\"95\"\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eSubdural hematoma\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e \u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eKameda 2015 (ref 24)\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 23.7pt;\" width=\"47\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e96/M\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 79.65pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 23.7pt;\" width=\"106\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003enegative\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 83.35pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 23.7pt;\" width=\"111\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eGait disturbs+ anorexia. Trauma+ subdural hematoma (7 mo before). \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 23.7pt;\" width=\"113\"\u003e\n\u003cp\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eBrain mass: DLBCL EBV+.\u0026nbsp; \u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n\u003cp\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eSubdural hematoma:\u0026nbsp; FA-DLBCL.\u003c/span\u003e\u003c/em\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp; No continuity among 2 lesions\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 127.6pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 23.7pt;\" width=\"170\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eCD20+, CD79\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: Symbol;\"\u003ea\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e+, CD3-, CD4-, CD7-, CD8-, LMP1+, EBNA2+, EBER+. Ig clonality NP.\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.95pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 23.7pt;\" width=\"124\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eCT Staging: neg at presentation.\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; Brain mass+ subdural hematoma resection. IT MTX + cytarabine+\u0026nbsp; glucocorticoids \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.95pt; border: solid black 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt; height: 23.7pt;\" width=\"105\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eDied after 3 mo for lymphoma dissemination. No autopsy\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 46.25pt;\"\u003e\n\u003ctd style=\"width: 70.9pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 46.25pt;\" width=\"95\"\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eSubdural\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e \u003cstrong\u003ehematoma\u003c/strong\u003e\u003c/span\u003e\u003c/em\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e Boyer\u0026nbsp; 2017 (ref 9)\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 46.25pt;\" width=\"47\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e25/M\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 79.65pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 46.25pt;\" width=\"106\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003enegative\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 83.35pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 46.25pt;\" width=\"111\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eSD hematoma since child. Hydrocephalus+ SD catheter. Steroid tp for pituitary overactivity\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 46.25pt;\" width=\"113\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eFoci of large lymphoid cells within hematoma\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 127.6pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 46.25pt;\" width=\"170\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eCD20+, PAX5+, MUM1+, CD10-BCL6-, CD30+, HHV8-, KI67\u0026gt;90%; EBER+, LMP1+. Ig clonality NP.\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.95pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 46.25pt;\" width=\"124\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eCT/PET/BM Staging: neg.\u0026nbsp;\u0026nbsp; Surgery only\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.95pt; border: solid black 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt; height: 46.25pt;\" width=\"105\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eNED at 7 mo\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 96.55pt;\"\u003e\n\u003ctd style=\"width: 70.9pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 96.55pt;\" width=\"95\"\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eArachnoid cyst\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e \u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eKirshenbaum 2017\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; (ref 25)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 96.55pt;\" width=\"47\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e81/M\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 79.65pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 96.55pt;\" width=\"106\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003enegative\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 83.35pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 96.55pt;\" width=\"111\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eTremor, gait ataxia, memory disturbs\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 96.55pt;\" width=\"113\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eFoci of large lymphoid cells within fibrin\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 127.6pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 96.55pt;\" width=\"170\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eCD20+ CD30+, BCL2+, MUM1+, BCL6+/-, CD10-, TdT-, CD5-, cMYC+ (50%) Ki67: \u0026gt;80%.\u0026nbsp;\u0026nbsp; EBER+.\u0026nbsp; FISH MYC -. Ig clonality +.\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.95pt; border-top: none; border-left: solid black 1.0pt; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 96.55pt;\" width=\"124\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eCT/PET staging: neg Surgery (cyst excision)+\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; R-lenalidomide\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.95pt; border: solid black 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt; height: 96.55pt;\" width=\"105\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eNA\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003ctable style=\"margin-left: -1.9pt; border-collapse: collapse;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 46.35pt;\"\u003e\n\u003ctd style=\"width: 77.95pt; border: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 46.35pt;\" width=\"104\"\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eCerebral artery aneurysm\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003ePresent case\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.45pt; border: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 46.35pt;\" width=\"57\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e64/F\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 52.5pt; border: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 46.35pt;\" width=\"70\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003enegative\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.1pt; border: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 46.35pt;\" width=\"104\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eCerebral hemorrhage. Left middle cerebral artery aneurysm\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.25pt; border: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 46.35pt;\" width=\"107\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eFoci of large lymphoid cells within fibrin\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 143.2pt; border: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 46.35pt;\" width=\"191\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eCD20+/-, PAX5+, CD79\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: Symbol;\"\u003ea\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e+, CD30+, MUM1+, CD10-, BCL6-, EBER+, Ki67 90%.\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; Ig clonality NP.\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.75pt; border: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 46.35pt;\" width=\"133\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eCT/BM Staging: neg\u0026nbsp;\u0026nbsp;\u0026nbsp; Surgery only \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.9pt; border: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 46.35pt;\" width=\"105\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eNED at 5 mo\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eLITERATURE REVIEW OF FIBRIN-ASSOCIATED DIFFUSE LARGE B-CELL LYMPHOMA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp style=\"text-align: justify;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003eA: artery; AA: abdominal aorta; AF: aortofemoral; Asc. A: ascending aorta; AWSD: alive with stable disease; AZA: azathioprine; BM: bone marrow; CEOP: cyclophosphamide, etoposide, oncovin, prednisone; CHOP: cyclophosphamide, doxorubicin, vincristine, prednisone; retro: retroperitoneum CIA: common iliac arteries; CH: chemotherapy; CVP: cyclophosphamide, vincristine, prednisone; CT: Computerized tomography; DEXA: dexamethasone; F: female; IT: intrathecal; IR: infrarenal; Ig: immunoglobulin: IGH: immunoglobulin heavy chain; mo: months; M: male; MTX: methotrexate; MG: myasthenia gravis; NA: not available; NED: not evidence of disease; Neg: negative; NP: not performed; NS: not specified; PBL: plasmablastic lymphoma; popl. A: popliteal artery; R: rituximab; Retrop: retroperitoneum; RT: radiotherapy; SD: subdural; sy: syndrome; TAA: thoracoabdominal aorta; TCR: T cell receptor; THY: Thymoma; Tp: therapy; yrs: years.\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: justify;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: justify;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: justify;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: justify;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: justify;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: justify;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: justify;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 115%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: justify;\"\u003e\u0026nbsp;\u003c/p\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":true,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"bmc-cancer","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"bcan","sideBox":"Learn more about [BMC Cancer](http://bmccancer.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/bcan/default.aspx","title":"BMC Cancer","twitterHandle":"BMC_series","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true},"keywords":"Fibrin, B-cell, Lymphoma, Epstein-Barr virus","lastPublishedDoi":"10.21203/rs.2.12131/v3","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.2.12131/v3","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"Background: Fibrin-associated diffuse large B-cell lymphoma (FA-DLBCL) is a rare Epstein-Barr virus (EBV) positive lymphoproliferative disorder included in the current World Health Organization (WHO) classification. It arises within fibrinous material in the context of hematomas, pseudocysts, cardiac myxoma or in relation with prosthetic devices. In these clinical settings the diagnosis requires an high index of suspicion, because it does not form a mass itself, being composed of small foci of neoplastic cells. Despite overlapping features with diffuse large B-cell lymphoma associated with chronic inflammation, it deserves a separate classification, being not mass-forming and often following an indolent course. Case presentation: A 64-year-old immunocompetent woman required medical care for cerebral hemorrhage. Computed Tomography (CT) angiography identified an aneurysm in the left middle cerebral artery. A FA-DLBCL was incidentally identified within thrombotic material in the context of the arterial aneurysm. After surgical removal, it followed a benign course with no further treatment. Conclusions: The current case represents the first report of FA-DLBCL identified in a cerebral artery aneurysm, expanding the clinicopathologic spectrum of this rare entity. A complete literature review is additionally made.","manuscriptTitle":"Fibrin-Associated Large B-Cell Lymphoma: First Case Report Within A Cerebral Artery Aneurysm And Literature Review","msid":"","msnumber":"","nonDraftVersions":[{"code":3,"date":"2019-10-12 12:26:22","doi":"10.21203/rs.2.12131/v3","editorialEvents":[{"type":"communityComments","content":0},{"type":"checksComplete","content":"","date":"2019-11-18T12:00:00+00:00","index":"","fulltext":""},{"type":"decision","content":"Accept","date":"2019-08-21T12:00:00+00:00","index":"","fulltext":""},{"type":"editorAssigned","content":"","date":"2019-08-20T12:00:00+00:00","index":"","fulltext":""},{"type":"editorInvited","content":"","date":"2019-08-19T12:00:00+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"bmc-cancer","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"bcan","sideBox":"Learn more about [BMC Cancer](http://bmccancer.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/bcan/default.aspx","title":"BMC Cancer","twitterHandle":"BMC_series","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true}},{"code":2,"date":"2019-09-13 18:03:10","doi":"10.21203/rs.2.12131/v2","editorialEvents":[{"type":"communityComments","content":0},{"type":"decision","content":"Minor revision","date":"2019-08-20T12:00:00+00:00","index":"","fulltext":""},{"type":"editorAssigned","content":"","date":"2019-08-08T12:00:00+00:00","index":"","fulltext":""},{"type":"reviewersInvited","content":"","date":"2019-08-08T12:00:00+00:00","index":"","fulltext":""},{"type":"reviewerAgreed","content":"","date":"2019-08-08T12:00:00+00:00","index":1,"fulltext":""},{"type":"reviewerAgreed","content":"","date":"2019-08-08T12:00:00+00:00","index":2,"fulltext":""},{"type":"editorInvitedReview","content":"","date":"2019-08-08T12:00:00+00:00","index":1,"fulltext":"Form responses:\n---\n* Does the work include the necessary controls?\nIf not, please specify which controls are required in your comments to the authors.\tYes: **Are the conclusions drawn adequately supported by the data shown?\nIf not, please explain in your comments to the authors.\tYes**\n"},{"type":"editorInvitedReview","content":"","date":"2019-08-08T12:00:00+00:00","index":2,"fulltext":"Form responses:\n---\n* Does the work include the necessary controls?\nIf not, please specify which controls are required in your comments to the authors.\tYes: **Are the conclusions drawn adequately supported by the data shown?\nIf not, please explain in your comments to the authors.\tYes**\n"},{"type":"checksComplete","content":"","date":"2019-08-07T12:00:00+00:00","index":"","fulltext":""},{"type":"editorInvited","content":"","date":"2019-08-07T12:00:00+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"bmc-cancer","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"bcan","sideBox":"Learn more about [BMC Cancer](http://bmccancer.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/bcan/default.aspx","title":"BMC Cancer","twitterHandle":"BMC_series","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC 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conclusions drawn adequately supported by the data shown?\nIf not, please explain in your comments to the 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