Study of the mechanisms by which Sambucus williamsii HANCE extract exert protective effects against ovariectomy-induced osteoporosis in vivo

Yue Zhang, Q Li, Hoi-Ying Wan, Hui Xiao, Wan‐Ping Lai, Xin‐Sheng Yao, Man‐Sau Wong
In: Osteoporosis International · 2010 · vol. 22(2) , pp. 703–709 · doi:10.1007/s00198-010-1240-3 · PMID:20414641 · W2065506983
article OA: closed CC0
View on OpenAlex View on PubMed View at publisher

Abstract

UnlabelledThe purpose of this study is to investigate the dose-dependent effects of SWH on bone properties and the mechanism involved in mediating the osteoprotective actions of SWH. The results indicated that SWH could improve bone properties by inhibiting the process of bone resorption and stimulating the process of bone formation.IntroductionOur previous study showed that Sambucus williamsii HANCE (SWH) improved trabecular bone mass and cortical bone strength in ovariectomized (OVX) rats. The purpose of this study is to investigate the dose-dependent effects of SWH on bone properties and the mechanism involved in mediating the osteoprotective actions of SWH.MethodsThree-month-old C57BL/6J mice were fed a phytoestrogen-free diet and subjected to either ovariectomy or sham operation. OVX mice were treated with genistein (50 mg/kg), or a low (200 mg/kg), medium (500 mg/kg), or high (1,000 mg/kg) dose of SWH extract.ResultsSWH could dose-dependently decrease urinary Ca excretion and increase serum Ca level in OVX mice. It could increase tibial bone mineral density and exert beneficial effects on the microarchitecture of trabecular bone in the OVX mice. SWH suppressed the ovariectomy-induced expression of Cbfa1 mRNA and cathepsin K mRNA and enhanced the ratio of OPG/RANKL mRNA expression in the tibia. In vitro study showed that SWH dramatically reduced the number of TRAP-positive cells in RANKL-induced RAW 264.7 cells.ConclusionsThe present study indicated that SWH could improve bone properties by inhibiting the process of bone resorption and stimulating the process of bone formation.

My notes (saved in your browser only)

Citation neighborhood (no data yet)

We don't have any in-corpus citations linked to this paper yet. The paper's references may be in our DB but unresolved to ``paper_id`` (resolution happens at ingest when the cited DOI matches a row we already have). Run the cross-source citation reconcile pass to retry.

References (26)

Source provenance

openalex
last seen: 2026-05-11T06:00:05.006021+00:00
unpaywall
last seen: 2026-08-28T06:28:33.284919+00:00
License: CC0 · commercial use OK