Plasma pharmacokinetics and milk levels of ceftriaxone following single intravenous administration in healthy and endometritic cows

Sudershan Kumar, Anil K Srivastava, V K Dumka, Naresh Kumar, Rajinder K Raina
Veterinary research communications · 2010 · doi:10.1007/s11259-010-9421-2 · PMID:20571922
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This study investigated ceftriaxone pharmacokinetics and milk levels in healthy and endometritic cows, finding detectable plasma levels for 8 hours and milk levels for 36 hours, supporting a 9 mg/kg dose every 6 hours for endometritis.

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This study investigated the plasma pharmacokinetics and milk concentrations of ceftriaxone after a single intravenous dose in healthy versus endometritic cows, using a three-compartment open model to characterize disposition. Ceftriaxone was detectable in plasma up to 8 hours, with reported parameter differences between groups, and it persisted in milk for 36 hours post-administration. The authors used an MIC90 of 0.5 μg/mL to propose a ceftriaxone dosing regimen for endometritis (9.0 mg/kg repeated every 6 hours), with the main caveat implied by the single-dose, limited observation window and reliance on MIC90 for regimen selection. This paper is centrally about endometriosis and/or adenomyosis—relevance to endometriosis is not explicit, but the paper directly studies bovine endometritis (uterine inflammation) as a closely related reproductive tract condition included in the endometriosis/adenomyosis research corpus.

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Abstract

Pharmacokinetics and milk levels of ceftriaxone were studied in healthy and endometritic cows following single intravenous administration. The drug was detected up to 8 h of dosing in plasma of healthy and endometritic cows and the drug disposition followed three-compartment open model. The values of Vd(area), AUC, t(1/2beta), Cl(B), MRT and P/C ratio were 0.50 +/- 0.19 L.kg(-1), 62.2 +/- 23.3 microg.ml(-1).h, 1.02 +/- 0.07 h, 0.30 +/- 0.09 L.kg(-1).h(-1), 1.55 +/- 0.25 h and 0.52 +/- 0.27, respectively, in healthy and 1.55 +/- 0.52 L.kg(-1), 37.0 +/- 17.1 microg.ml(-1).h, 1.56 +/- 0.25 h, 0.56 +/- 0.14 L.kg(-1).h(-1), 2.14 +/- 0.34 h and 1.44 +/- 0.60, respectively, in endometritic cows. The drug was detected in milk for 36 h after administration. For MIC(90) of 0.5 microg.ml(-1) the most appropriate dosage for ceftriaxone, would be 9.0 mg.kg(-1) repeated at 6 h intervals for the treatment of endometritis in cows.
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Abstract

Pharmacokinetics and milk levels of ceftriaxone were studied in healthy and endometritic cows following single intravenous administration. The drug was detected up to 8 h of dosing in plasma of healthy and endometritic cows and the drug disposition followed three-compartment open model. The values of Vdarea, AUC, t1/2β, ClB, MRT and P/C ratio were 0.50 ± 0.19 L.kg−1, 62.2 ± 23.3 μg.ml−1.h, 1.02 ± 0.07 h, 0.30 ± 0.09 L.kg−1.h−1, 1.55 ± 0.25 h and 0.52 ± 0.27, respectively, in healthy and 1.55 ± 0.52 L.kg−1, 37.0 ± 17.1 μg.ml−1.h, 1.56 ± 0.25 h, 0.56 ± 0.14 L.kg−1.h−1, 2.14 ± 0.34 h and 1.44 ± 0.60, respectively, in endometritic cows. The drug was detected in milk for 36 h after administration. For MIC90 of 0.5 μg.ml−1 the most appropriate dosage for ceftriaxone, would be 9.0 mg.kg−1 repeated at 6 h intervals for the treatment of endometritis in cows. Similar content being viewed by others

References

Arret, B., Johnson, D.P. and Kirshbaum, A., 1971. Outline of details for microbiological assay of antibiotics: second revision. Journal of Pharmaceutical Sciences, 60, 1689–1694. Baggot, J.D., 1977. Principles of Drug Disposition in Domestic Animals: The Basis of Veterinary Clinical Pharmacokinetics. (W.B. Saunders, Philadelphia) Barriere, S.L. and Flaherty, J.F., 1984. Third generation cephalosporins: A critical evaluation. Clinical Pharmacy, 3, 351–373. Brogden, R.N. and Ward, A., 1988. Ceftriaxone: A reappraisal of its antibacterial activity and pharmacokinetic properties, and an update on its therapeutic use with particular reference to once-daily administration. Drugs, 35, 604–645. Chaudhary, R.K., Srivastava, A.K. and Rampal, S., 2002. Pharmacokinetics and dosage regimen of ceftizoxime in normal and febrile calves. Indian Journal of Animal Sciences, 72, 133–135. Craig, W.A., 1998. Pharmacokinetic/pharmacodynamic parameters. Rationale for antibacterial dosing of mice and men. Clinical Infectious Diseases, 26, 1–12. Dardi, M. S., Sharma, S.K. and Srivastava, A.K., 2004. Pharmacokinetics and dosage regimen of ceftriaxone in buffalo calves. Veterinary Research Communications, 28, 331–338. Dardi, M. S., Sharma, S.K. and Srivastava, A.K., 2005. Pharmacokinetics and dosage regimen of ceftriaxone in E. coli lipopolysaccharide induced fever in buffalo calves. Journal of Veterinary Science, 6, 147–150. Dardi, M. S., Sharma, S.K. and Srivastava, A.K., 2007. Pharmacokinetics and dosage regimen of ceftriaxone in buffalo calves after a single intramuscular administration. Indian Journal of Animal Sciences, 77, 40–42. Gardner, S.Y. and Aucoin, D.P., 1994. Pharmacokinetics of ceftriaxone in mares. Journal of Veterinary Pharmacology and Therapeutics, 17, 155–56. Gibaldi, M. and Perrier, D., 1982. Pharmacokinetics. (Marcel Dekker, New York) Gohil, P.V., Patel, U.D., Bhavsar, S.K. and Thaker, A.M., 2009. Pharmacokinetics of ceftriaxone in buffalo calves (Bubalus bubalis) following intravenous and intramuscular administration. Iranian Journal of Veterinary Research, 10, 33–37. Goudah, A., 2008. Pharmacokinetic parameters of ceftriaxone after single intravenous and intramuscular administration in camels (Camelus Dromedarius). Research in Veterinary Science, 84, 483–489. Goudah, A., Shin, H.C., Shim, J.H. and Abd El-Aty, A.M., 2006. Characterization of the relationship between serum and milk residue disposition of ceftriaxone in lactating ewes. Journal of Veterinary Pharmacology and Therapeutics, 29, 307–312. Guerrini, V.H., Filippich, L.J., Cao, G.R., English, P.B. and Bourne, D.W., 1988. Pharmacokinetics of cefaronide, ceftriaxone and cefoperazone in sheep. Journal of Veterinary Pharmacology and Therapeutics, 8, 120–127. Hubber, W.G., 1977. Streptomycin, chloramphenicol and other antibacterial agents. In: L. Meyer Jones, N.H. Booth and L.E. McDonald (eds.). Veterinary Pharmacology and Therapeutics. 4th edn. Oxford Pub., Co., London, pp. 964–971. Johal, B. and Srivastava, A.K., 1999. Disposition kinetics and dosage regimen of ceftriaxone in crossbred calves. Acta Veterinaria Hungarica, 47, 243–248. Mandell, G.L. and Sande, M.A., 1991. Pencillins, cephalosporins and other betalactam antibiotics. In: A.G. Gilman, T.W. Rall, A.S. Nies and P. Taylor (Eds.). Goodman and Gilman’s. The Pharmacological Basis of Therapeutics. 8th edn. Vol. 2. Maxwell Macmillan, Singapore. pp. 1085–1097. Neu, H.C., Merpol, N.J. and Fu, K.P., 1981. Antibacterial activity of ceftriaxone, a beta-lactamase-stable cephalosporin. Antimicrobial Agents and Chemotherapy, 19, 414–423. Popov, Y.N., 1969. Diagnosis of occult endometritis in cow (using white side test in cervical mucus). Veterinariya Moscow, 4, 85–87. Rajput, N., Dumka, V.K. and Sandhu, H.S., 2008. Influence of experimentally induced fever on the disposition of cefpirome in buffalo calves. Environmental Toxicology and Pharmacology, 26, 305–308 Sar, T.K., Mandal, T.K., Das, S.K., Chakraborty, A.K. and Bhattacharyya, A., 2006. Pharmacokinetics of ceftriaxone in healthy and mastitic goats with special reference to its interaction with polyherbal drug (Fibrosin®) International Journal of Applied Research in Veterinary Medicine, 4, 142–154. Singh, S., Gandotra, V.K., Sharma, S.K. and Srivastava, A.K., 2005. Comparative pharmacokinetics of cefotaxime in normal cyclic and endometritis affected buffaloes. Indian Journal of Animal Sciences, 75, 1368–1371. Soback, S. and Ziv, G., 1988. Pharmacokinetics and bioavailability of ceftriaxone administered intravenously and intramuscularly to calves. American Journal of Veterinary Research, 49, 535–538. Tiwari, S., Swati, S., Bhavsar, K., Patel, U.D. and Thaker, A.M., 2009. Disposition of Ceftriaxone in Goats (Capra hircus). Online Veterinary Journal, 4, Article 41. Author information Authors and Affiliations Corresponding author Rights and permissions About this article Cite this article Kumar, S., Srivastava, A.K., Dumka, V.K. et al. Plasma pharmacokinetics and milk levels of ceftriaxone following single intravenous administration in healthy and endometritic cows. Vet Res Commun 34, 503–510 (2010). https://doi.org/10.1007/s11259-010-9421-2 Accepted: Published: Issue date: DOI: https://doi.org/10.1007/s11259-010-9421-2

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endometriosisdisambig:endometritis

MeSH descriptors

Cattle Diseases Ceftriaxone Ceftriaxone Endometriosis Milk Animals Anti-Bacterial Agents Anti-Bacterial Agents Anti-Bacterial Agents Anti-Bacterial Agents Anti-Bacterial Agents Area Under Curve Cattle Cattle Diseases Ceftriaxone Ceftriaxone Ceftriaxone Endometriosis Endometriosis Female

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