Mutational DNA profile in non-atypical endometriomas using Next-generation-sequencing

Endometriosis is a common gynecologic disorder, affecting at least 6 – 10% of reproductive-aged women. Endometriotic implants are observed all over the pelvis but the endometriosis-associated cancers typically arise in endometriomas. This observations rise up the question whether the special ovarian cyst environment, especially oxidative stress caused by free „catalytic“ iron, induces cancer driver gene mutations in endometriotic implants that may lead to carcinogenic transformation in these cysts.