Clinical efficacy and safety of GnRH-a combined with estrogen-dydrogesteronea in the treatment for endometriosis

Objective To investigate the clinical efficacy and safety of GnRH-a combined with estrogen-dydrogesteronea in the treatment for endometriosis.Methods 86 cases of endometriosis admitted to our hospital from January 2009 to December 2010 were randomly divided into two groups,control group(n=43)and treatment group(n=43).The control group was given triptorelin acetate only,and the treatment group was given estradiol valerate and medroxyprogesterone acetate at the same time.The levels of CA125 and sex hormones,scores of VAS and Kupperman,the incidence of menopause symptoms and adverse reactions of the two groups were observed and compared.Results The levels of CA125 and sex hormones of the two groups after treatment were significantly reduced,and the level of E2 of treatment group was significantly higher than that of control group(P0.05);the scores of VAS and Kupperman of the two groups after treatment was significantly reduced,and the scores of hot flashes of treatment group was significantly lower than that of control group(P0.05);the incidence of hot flashes and night sweats,bone pain of treatment group were significantly less than those of control group(P0.05).Conclusion Clinical application of GnRH-a combined with estrogen-dydrogesteronea can alleviate the symptoms of low hormone and reduce menopause,and decrease the rate adverse reactions in the treatment for endometriosis.