The Peritoneal Macrophages in Inflammatory Diseases and Abdominal Cancers

Ting Liu, Fang Liu, Leiwen Peng, Chang Li, Yong-Mei Jiang, Yongmei Jiang
In: Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics · 2017 · vol. 26(5) , pp. 817–826 · doi:10.3727/096504017x15130753659625 · PMID:29237519 · W2773134890
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This review covers the characterization and immunological function of peritoneal macrophages in inflammatory diseases and abdominal cancers, highlighting their role in regulating immune responses and their potential as immunotherapy targets.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-10 · read from full text ⓘ

This paper is a review of peritoneal macrophages (PMs), the predominant peritoneal cell type, focusing on their roles in innate and acquired immunity. It describes how PMs release both pro- and anti-inflammatory cytokines that regulate differentiation of innate immune cells and inflammatory T cells, and it synthesizes evidence that PM immunological and inflammatory responses are linked to pathogenic processes in multiple inflammatory diseases and abdominal cancers. The paper frames PM activation regulation as a potential immunotherapy target, while noting that the distinct biological functions of PMs likely vary by disease and thus require further understanding for designing disease-specific agents. Relevance to endometriosis: The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

Peritoneal macrophages (PMs) are the major cell type of peritoneal cells that participate in multiple aspects of innate and acquired immunity in the peritoneal cavity. PMs have an ability to release a large amount of proinflammatory and anti-inflammatory cytokines and therefore play a critical role in regulating the differentiation of innate immune cells and inflammatory T cells. Accumulating studies demonstrate that the immunological reactions and inflammatory responses of PMs are strongly related to the pathogenic processes of various inflammatory diseases and abdominal cancers. Consequently, the regulation of PM activation has gradually emerged as a promising target for immunotherapy, and better understanding of the distinctly biological function of PMs in individual diseases is crucial for designing specific and effective therapeutic agents. This review covers the characterization and immunological function of PMs in hosts with inflammatory diseases and abdominal cancers.
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Open Access REVIEW The Peritoneal Macrophages in Inflammatory Diseases and Abdominal Cancers Department of Laboratory Medicine, West China Second University Hospital, and Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, Sichuan University, Chengdu, P.R. China 1 These authors provided equal contribution to this work. Oncology Research 2018, 26(5), 817-826. https://doi.org/10.3727/096504017X15130753659625 Abstract Peritoneal macrophages (PMs) are the major cell type of peritoneal cells that participate in multiple aspects of innate and acquired immunity in the peritoneal cavity. PMs have an ability to release a large amount of proinflammatory and anti-inflammatory cytokines and therefore play a critical role in regulating the differentiation of innate immune cells and inflammatory T cells. Accumulating studies demonstrate that the immunological reactions and inflammatory responses of PMs are strongly related to the pathogenic processes of various inflammatory diseases and abdominal cancers. Consequently, the regulation of PM activation has gradually emerged as a promising target for immunotherapy, and better understanding of the distinctly biological function of PMs in individual diseases is crucial for designing specific and effective therapeutic agents. This review covers the characterization and immunological function of PMs in hosts with inflammatory diseases and abdominal cancers.Keywords Cite This Article This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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