To Evaluate the Apoptosis Gene in Relation to Endometriosis

Junqi Ma

doi:10.3877/cma.j.issn.1673-5250.2008.05.110

To Evaluate the Apoptosis Gene in Relation to Endometriosis

Junqi Ma

In: Chung-Hua Fu Ch'an K'o Tsa Chih · 2008 · vol. 4(5) , pp. 443–450 · doi:10.3877/cma.j.issn.1673-5250.2008.05.110 · W3032317459

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This study measured mRNA expression of Survivin, Bcl-2, and Cox-2 in endometriosis patients, finding significant up-regulation in both ectopic and eutopic endometrium compared to controls.

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This study investigated the molecular mechanisms underlying endometriosis by measuring the mRNA expression levels of survivin, Bcl-2, and Cox-2 in ectopic and eutopic endometrial tissues from 32 patients compared to 32 healthy controls. Using semi-quantitative reverse transcription-polymerase chain reaction, the researchers found that all three genes were significantly upregulated in the ectopic endometrium, while only survivin was elevated in the eutopic endometrium relative to normal tissue. The results indicated a positive correlation between the overall expression of these apoptosis-related genes and the presence of endometriosis, suggesting their involvement in lesion implantation and progression. This paper is centrally about endometriosis — specifically examining the role of apoptosis-related gene expression in its pathogenesis.

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Abstract

Objective To evaluate the molecular mechanism by measuring the gene expression of Survivin, Bcl-2 and Cox-2 in patients with endometriosis(EMS) and investigate their effects on the initiation and maintenance of endometriosis. Methods From January 2006 to November 2006, the ectopic endometrium and eutopic endometrium were obtained from 32 patients with endometriosis (EMS group) and from 32 normal endometrium(the control group). Informed consent was obtained from all patients. The mRNA expression of survivin, bcl-2 and cox-2 were measured by semi-quantitative reverse transcription-polymerase chain reaction(RT-PCR). Results Compared to normal group, the mRNA levels of survivin of ectopic endometrium and eutopic endometrium were significantly increased, the mRNA levels of bcl-2, cox-2 were significantly increased too. The total mRNA levels of survivin, bcl-2 and cox-2 were positively correlated with endometriosis, and the correlations of three were obvious. Conclusion Abnormal up-regulation of Survivin, Bcl-2 and Cox-2 in the endometriosis patients might be one of molecular biologic mechanisms for ecotopic implantation and development of endometrium. Furthermore, three genes were highly associated to the endometriosis progress. Key words: endometriosis (EMS); Survivin; Bcl-2; Cox-2; gene expression

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Objective

To evaluate the molecular mechanism by measuring the gene expression of Survivin, Bcl-2 and Cox-2 in patients with endometriosis(EMS) and investigate their effects on the initiation and maintenance of endometriosis.

Methods

From January 2006 to November 2006, the ectopic endometrium and eutopic endometrium were obtained from 32 patients with endometriosis (EMS group) and from 32 normal endometrium(the control group). Informed consent was obtained from all patients. The mRNA expression of survivin, bcl-2 and cox-2 were measured by semi-quantitative reverse transcription-polymerase chain reaction(RT-PCR).

Results

Compared to normal group, the mRNA levels of survivin of ectopic endometrium and eutopic endometrium were significantly increased, the mRNA levels of bcl-2, cox-2 were significantly increased too. The total mRNA levels of survivin, bcl-2 and cox-2 were positively correlated with endometriosis, and the correlations of three were obvious.

Conclusion

Abnormal up-regulation of Survivin, Bcl-2 and Cox-2 in the endometriosis patients might be one of molecular biologic mechanisms for ecotopic implantation and development of endometrium. Furthermore, three genes were highly associated to the endometriosis progress. | 1 Giudice LC, Tazuke SI, Swiersz L. Status of current research on endometriosis. J Reprod Med, 1998，43(Suppl 3)：252－262. | | | 2 Selam B, Arici A. Implantation defect in endometriosis: Endometrium or peritoneal fluid. J Reprod Fertil Suppl，2000，55：121－128. | | | 3 Suganuma N, Harada M, Furuhashi M, et al. Apoptosis in human endometrial and endometriotic tissues. Horm Res，1997，48(Suppl 3)：42－47. | | | 4 Kennedy S. Genetics of endometriosis：A review of the positional cloning approaches. Semin Reprod Med，2003，21：111－118. | | | 5 Lang JH. Cornerstone of study on endometriosis. Chin J Obstet Gynecol, 2005，40(1)：3－4.[郎景和. 子宫内膜异位症研究的新里程. 中华妇产科杂志，2005, 40(1)：3－4.] | | | 6 LaCasse EC, Baird S, Korneluk RG, et al. The inhibitors of apoptosis (IAPS) and their emerging role in cancer. Oncogene，1998, 17(25)：3247－3259. | | | 7 Sung BJ, Cho YS, Kim HJ, et al. An anti－apoptotic protein human survivin is a direct inhibitor of caspase－3 and －7.Biochemistry, 2001，40(4): 1117－1126. | | | 8 Suzuki A, Ito T, Kawano H，et al.Survivin initiates procaspase－3/p21 complex formation as a result of interaction with CDK4 to resist fas－mediated cell death.Oncogene，2000，19(10)：1346－1355. | | | 9 Wheatley SP, McNeish IA. A protein with dual roles in mitosis and apoptosis. INT Rev Cytol, 2005，247(1)：34－88. | | | 10 Parenti A，Leo G，Porzionato A, et al. Expression of survivin, p53, and caspase 3 in Barrett's esophagus carcinogenesis. Hum Pathol, 2006, 37(1)：16－22. | | | 11 Papapetropoulos A，Fulton D，Mubboubi K, et al. Angiopoietin－1 inhibits endothelial cell. J Biol Chem, 2002，275(13)：9102. | | | 12 Oconnor DS, Schechner JS, Adida C, et al. Control of apoptosis during angiogenesis by surviving express in endothelial cell. Am J Pathol，2000，156(2)：393. | | | 13 Letsas KP, Frangou LM, Skyrlas A, et al. Transcription factor－mediated proliferation and apoptosis in benign and malignant thyroid lesions. Pathol Int, 2005，55(11): 694－702. | | | 14 Gong FL, editor. Apoptosis and immunity. Med Immunol, Beijing：Science Publishing House，2004, 6：251－263.[龚非力主编. 医学免疫学. 北京：科学出版社，2004，251－263.] | | | 15 Chishima F, Hayakawa S, Sugita K，et al.Increased expression of cycloosygenase－2 in local lesions of endometriosis patients.Am J Reprod Immunol，2002，48(1)：50－56. | | | 16 Ota H, Igarashi S, Sasaki M, et al. Distribution of cyclooxygenase－2 in eutopic and ectopic endometrium in endometriosis and adenomyosis. Hum Reprod, 2001, 16(3)：561－566. | | | 17 Lin MT, Lee RC, Yang PC，et al. Cyclooxygenase－2 inducing Mcl－1－dependent survival mechanism in human lung adrnocarcinoma CL1.0 cells. Involvement of phosphatidylinositol 3－kinase/Akt pathway. J Biol Chem, 2001，276：48997－49002. | | | 18 Lang JH.Summary of the eighth international congresses on endometriosis. Chin J Obstet Gynecol，2002，37：638－4－640.[郎景和，冷金花，赵栋等. 第八届国际子宫内膜异位症学术会议纪要. 中华妇产科杂志，2002，37(1)：638－640.] | | [1] | 朱成美, 赵巧梅, 邓学东. 经阴道超声联合生理盐水灌注直肠子宫陷凹对腹膜型子宫内膜异位症的诊断价值[J/OL]. 中华医学超声杂志（电子版）, 2024, 21(01): 32-36. | | [2] | 林桦, 秦超, 骆宁, 刘宏伟, 于泳浩. 烧伤大鼠肝组织关键基因的筛选[J/OL]. 中华危重症医学杂志(电子版), 2023, 16(06): 448-452. | | [3] | 乔林. 子宫内膜异位症鉴别诊断病例分享[J/OL]. 中华妇幼临床医学杂志(电子版), 2024, 20(02): 248-. | | [4] | 魏丽坤, 张旭红, 罗营, 薛凤霞, 王颖梅, 宋学茹, 田丽娜, 张艳芳, 王艳霞, 田文艳. 卵巢子宫内膜异位囊肿发生恶变并发盆腔脓肿1例并文献复习[J/OL]. 中华妇幼临床医学杂志(电子版), 2023, 19(06): 696-702. | | [5] | 张琳, 李婷. CRIP1在胃癌中的表达及与临床病理指标和预后的关系研究[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(02): 171-175. | | [6] | 邱凌霄, 王创业, 卿斌, 刘锦程, 张鑫烨, 武文娟, 邢德冰, 郭亮, 徐智, 王斌. 基于转录组学筛选特发性肺纤维化的枢纽基因和信号通路[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(02): 212-217. | | [7] | 胡启明, 鄢潇, 尤志学, 黄骁昊. 经瘢痕处单孔腹腔镜下切除多病灶腹壁子宫内膜异位症[J/OL]. 中华腔镜外科杂志(电子版), 2024, 17(05): 314-317. | | [8] | 张蕾, 彭超, 周应芳. 直肠阴道隔子宫内膜异位症腹腔镜手术技巧[J/OL]. 中华腔镜外科杂志(电子版), 2024, 17(05): 257-261. | | [9] | 王庭宇, 邵联波, 刘珊, 沈振亚. Stanford A 型主动脉夹层相关基因KIF20A 的共表达网络构建及作用靶点分析[J/OL]. 中华细胞与干细胞杂志(电子版), 2024, 14(05): 303-312. | | [10] | 芦煜, 李振宇, 吴承东, 周仲伍. 肛周子宫内膜异位症一例报告[J/OL]. 中华结直肠疾病电子杂志, 2024, 13(05): 431-434. | | [11] | 李京, 牛博, 刘晓蓓, 魏新雪, 黄荣. circ-SESN2 沉默靶向调控miRNA-23a-5p/ULK1 在神经细胞氧化应激损伤中的作用机制研究[J/OL]. 中华神经创伤外科电子杂志, 2024, 10(05): 263-272. | | [12] | 陈娟, 邓静敏. 胸部子宫内膜异位综合征的研究进展[J/OL]. 中华临床医师杂志(电子版), 2024, 18(01): 96-100. | | [13] | 王飞飞, 王光林, 孟泽松, 李保坤, 曹龙飞, 张娟, 周超熙, 丁源一, 王贵英. 敲低IMPDH1对结肠癌SW480、HT29细胞生物功能的影响[J/OL]. 中华临床医师杂志(电子版), 2023, 17(08): 884-890. | | [14] | 王丁然, 迟洪滨. 自身免疫甲状腺炎对子宫内膜异位症患者胚胎移植结局的影响[J/OL]. 中华临床医师杂志(电子版), 2023, 17(06): 682-688. | | [15] | 洪凡, 陈敦金, 傅洋, 梁新月, 吴毅, 王晓怡. 体外受精-胚胎移植妊娠合并前置胎盘临床研究[J/OL]. 中华产科急救电子杂志, 2024, 13(03): 176-182. | | 阅读次数 | ||||| | 全文 | | |||| | 摘要 | | |||| 版权所有中华医学会中华医学电子音像出版社有限责任公司京ICP备14006079号-1 网络出版服务许可证：(署)网出证(京)字第075号 AI 小编 AI小编

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