Expression of long non-coding RNAs ROR and MALAT1 in uterine fibroids

С А Леваков, G.Ya. Azadova, A.E. Mamedova, Kh.R. Movtaeva, M.I. Maslyakova, Marat S. Pavlyukov, M. I. Shakhparonov, Н. В. Антипова
In: Voprosy ginekologii, akušerstva i perinatologii · 2021 · vol. 20(4) , pp. 17–21 · doi:10.20953/1726-1678-2021-4-17-21 · W3209039696
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This study found that uterine fibroid tissues exhibit decreased ROR and increased MALAT1 expression compared to normal myometrium, a pattern correlating with findings in endometriosis.

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This study investigated the expression levels of long non-coding RNAs ROR and MALAT1 in tissue samples from 28 women with uterine fibroids compared to normal myometrium. Using real-time reverse-transcription polymerase chain reaction, the researchers found a significant decrease in ROR expression and an increase in MALAT1 expression within the fibroid tissues. The authors note that these findings correlate with data previously obtained for patients with endometriosis, suggesting a potential shared molecular mechanism, although further research is needed to clarify the clinical significance and underlying actions of these RNAs. Relevance to endometriosis: mentioned only as a comparative correlation for similar lncRNA expression patterns, while the paper's main focus is uterine fibroids.

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Abstract

Objective. To study the expression level of long non-coding RNAs ROR and MALAT1 in tissue samples of uterine fibroids. Patients and methods. Samples of myomatous nodes and tissues of normal myometrium in 28 women of reproductive age were examined. The analysis of the expression of long non-coding RNAs was carried out using a real-time reverse-transcription polymerase chain reaction (RT-PCR) with specific primers. Results. There was a significant decrease in the expression level of long non-coding RNA ROR and an increase in the MALAT1 expression in tissue samples of uterine fibroids relative to the control group. Conclusion. The results obtained demonstrate a possible role of long non-coding RNAs in the development of uterine fibroids and correlate with the data which we obtained for patients with endometriosis. Detecting the expression level of long non-coding RNAs can improve the existing methods for diagnosing this disease. However, further research is required to determine the clinical significance of MALAT1 and ROR, and the molecular mechanisms underlying the action of these RNAs in uterine fibroid cells. Key words: long non-coding RNAs, uterine fibroids, myomectomy, lncROR, MALAT1
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Expression of long non-coding RNAs ROR and MALAT1 in uterine fibroids Sergey A. Levakov / Gyullar Yа. Azadova / Ainura E. Mamedova / Khadizhat R. Movtaeva / Marina I. Maslyakova / Marat S. Pavlyukov / Mikhail I. Shakhparonov / Olga N. Vetchinnikova / Objective. To study the expression level of long non-coding RNAs ROR and MALAT1 in tissue samples of uterine fibroids. Patients and methods. Samples of myomatous nodes and tissues of normal myometrium in 28 women of reproductive age were examined. The analysis of the expression of long non-coding RNAs was carried out using a real-time reverse-transcription polymerase chain reaction (RT-PCR) with specific primers. Results. There was a significant decrease in the expression level of long non-coding RNA ROR and an increase in the MALAT1 expression in tissue samples of uterine fibroids relative to the control group. Conclusion. The results obtained demonstrate a possible role of long non-coding RNAs in the development of uterine fibroids and correlate with the data which we obtained for patients with endometriosis. Detecting the expression level of long non-coding RNAs can improve the existing methods for diagnosing this disease. However, further research is required to determine the clinical significance of MALAT1 and ROR, and the molecular mechanisms underlying the action of these RNAs in uterine fibroid cells. Key words: long non-coding RNAs, uterine fibroids, myomectomy, lncROR, MALAT1 For citation: Levakov S.A., Azadova G.Ya., Mamedova A.E., Movtaeva Kh.R., Maslyakova M.I., Pavlyukov M.S., Shakhparonov M.I., Antipova N.V. Expression of long non-coding RNAs ROR and MALAT1 in uterine fibroids. Vopr. ginekol. akus. perinatol. (Gynecology, Obstetrics and Perinatology). 2021; 20(4): 17–21. (In Russian). DOI: 10.20953/1726-1678-2021-4-17-21

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