Histopathological study of endometrium in cases of abnormal uterine bleeding

Saroj Bolde, Smita S. Pudale, Gopal A. Pandit, Pushkar Matkari
In: International Journal of Research in Medical Sciences · 2014 · vol. 2(4) , pp. 1378 · doi:10.5455/2320-6012.ijrms20141125 · W2114883345
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This study examined the histopathological patterns of endometrium in abnormal uterine bleeding cases, finding proliferative endometrium and leiomyoma to be the most common diagnoses among women aged 30-49.

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This study analyzed histopathological patterns in endometrial specimens from patients presenting with abnormal uterine bleeding, focusing on correlations between age, clinical presentation, and tissue morphology. The majority of participants were aged 30 to 49 years, with menorrhagia being the most frequent menstrual disorder observed among the cohort. Results indicated that proliferative endometrium was the most common finding in dysfunctional cases, while organic lesions such as leiomyoma and endometrial hyperplasia were also prevalent; notably, endometriosis was identified in only a small fraction of cases. Relevance to endometriosis: listed as one organic cause of abnormal uterine bleeding encountered in the study, though the paper's main focus is the broader histopathological spectrum of endometrial pathology in dysfunctional uterine bleeding.

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Abstract

Background:Abnormal uterine bleeding is one of the commonest complaints in women and when it occurs without organic lesions like tumor, inflammation, it is called as dysfunctional uterine bleeding. Aim of current study was to find out the histopathological pattern of endometrium in Abnormal Uterine Bleeding (AUB) also to study organic causes of AUB.Methods:Specimens received as endometrial curettage and hysterectomy specimens were studied followed by correlation of histopathology with age and clinical presentation.Results:The patients were mainly from the age group of 30-49 years (74.24%). The most common menstrual disorder was menorrhagia (46.86%). In dysfunctional uterine bleeding the most common histological pattern of endometrium includes proliferative endometrium (22.8%) followed by endometrial hyperplasia (19.40%), atrophic endometrium (7.16%), secretory endometrium (5.97%), irregular shedding [1.80%], irregular ripening (1.20%) and anovulatory endometrium (0.59%). Organic lesions encountered in AUB cases were leiomyoma (17.92%), endometrial polyp (1.79%), endometrial carcinoma (1.50%), endometriosis (0.59%) and choriocarcinoma (0.29%).Conclusion:It is important to know the histological pattern of the endometrium like proliferative endometrium, endometrial hyperplasia, atrophic endometrium, secretory endometrium, irregular ripening and shredding and organic lesions in patients diagnosed as AUB in different age groups since recognition of these conditions will help and will avoid further complications.
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Keywords

Atypical uterine bleeding, Dysfunctional uterine bleeding, Endometrial hyperplasiaAbstract Background:Abnormal uterine bleeding is one of the commonest complaints in women and when it occurs without organic lesions like tumor, inflammation, it is called as dysfunctional uterine bleeding. Aim of current study was to find out the histopathological pattern of endometrium in Abnormal Uterine Bleeding (AUB) also to study organic causes of AUB. Methods:Specimens received as endometrial curettage and hysterectomy specimens were studied followed by correlation of histopathology with age and clinical presentation. Results:The patients were mainly from the age group of 30-49 years (74.24%). The most common menstrual disorder was menorrhagia (46.86%). In dysfunctional uterine bleeding the most common histological pattern of endometrium includes proliferative endometrium (22.8%) followed by endometrial hyperplasia (19.40%), atrophic endometrium (7.16%), secretory endometrium (5.97%), irregular shedding [1.80%], irregular ripening (1.20%) and anovulatory endometrium (0.59%). Organic lesions encountered in AUB cases were leiomyoma (17.92%), endometrial polyp (1.79%), endometrial carcinoma (1.50%), endometriosis (0.59%) and choriocarcinoma (0.29%). Conclusion:It is important to know the histological pattern of the endometrium like proliferative endometrium, endometrial hyperplasia, atrophic endometrium, secretory endometrium, irregular ripening and shredding and organic lesions in patients diagnosed as AUB in different age groups since recognition of these conditions will help and will avoid further complications. Metrics

References

Zeeba S. Jairajpuri, S. Rama and S. Jetky. Atypical uterine bleeding: histopathological audit of endometrium. A study of 638 cases. Al Ameen J Med Sci. 2013;6(1):21-8. Wahada Moohmad Taib Al-Neaimy, Manal Thanoon Ahmed, Safwan I. Al-Jawadi. Histopathological interpretation of Abnormal uterine bleeding after the age of 40 years. Iraqi Postgrad Med J. 2010;9(3):274-82. Ayesha Sarwar, Anwar ul Haque. Types and frequencies of pathologies in endometrial curettings of abnormal uterine bleeding. 2005;3(2):65-70. Bhoomika Dadhania, Gauravi Dhruva, Amit Agarval, Krupal Pujara. Histopathological study of endometrium in dysfunctional uterine bleeding. Int J Res Med. 2013;2(1):20-4. Archana Bhosle, Michelle Fonseca. Evaluation and histopathological correlation of abnormal uterine Bleeding in perimenopausal women. Bombay Hosp J. 2010;52(1):69-72. A. Khare, R. Bansal, S. Sharma, P. Elhence, N. Makkar, Y. Tyagi. Morphological spectrum of endometrium in patients presenting with dysfunctional uterine bleeding. People’s J Sci Res. 2012;5(2):13-6. Layla Abdullah, Nabeel S. Bondayji. Histopathological pattern of endometrial sampling performed for abnormal uterine bleeding. Bahrain Med Bull. 2011;33(4):1-6. Pilli GS, Sthi B, Dhaded AV. Dysfunctional uterine bleeding. Study of 100 cases. J Obstet Gynecol India. 2002;52(3):87-9. Vakiani M, Vavilis D, Agorastos T, Stamatopoulos P, Assimaki A, Bontis J. Histopathological findings of the endometrium in patients with dysfunctional uterine bleeding. Clin Exp Obstet Gynecol. 1996;23(4):236-9. Gerald Dafe Furae, Jonathan Umezuluike Aligbe. Histopathological patterns of endometrial lesions in patients with abnormal uterine bleeding in a cosmopolitan population. J Basic Clin Reprod Sci. 2013;2(2):101-4. Sadia Khan, Sadia Hameed, Aneela Umber. Histopathlogic pattern of endometrium on diagnostic D&C in patients with abnormal uterine bleeding. 2011;17(2):166-70.

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