Pure non-gestational ovarian choriocarcinoma in a postmenopausal woman coexisting with a clear cell adenofibroma and endometriosis foci: A case report and review of the literature
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This case report describes a rare occurrence of pure non-gestational ovarian choriocarcinoma in a postmenopausal woman, coexisting with a clear cell adenofibroma and endometriosis.
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Abstract
Ovarian germ cell tumours are uncommon, with choriocarcinoma being the rarest of them. Among choriocarcinomas, the non-gestational type occurs mainly in premenarchal women, although cases have been described in postmenopausal women. The distinction between gestational or non-gestational aetiology of choriocarcinoma is essential given the prognostic and therapeutic implications involved. The distinction between pure and mixed form of choriocarcinoma also has prognostic relevance. Clear cell adenofibroma is a rare benign lesion, considered a precursor of clear cell carcinoma, with described association to endometriosis. We present the case of a 72-year-old woman diagnosed at our centre with pure non-gestational choriocarcinoma, clear cell adenofibroma and foci of endometriosis present in the same ovary. We performed a review of the literature, focusing on how to differentiate a gestational from a non-gestational choriocarcinoma and the pure form from the mixed form, as well as the described coexistence between germ cell and epithelial tumours.
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Cites (3)
- Pathogenesis of Ovarian Clear Cell Adenofibroma, Atypical Proliferative (Borderline) Tumor, and Carcinoma: Clinicopathologic Features of Tumors with Endometriosis or Adenofibromatous Components Support Two Related Pathways of Tumor Development 2011
- Endometriosis and malignancy: The intriguing relationship 2021
- Clear Cell Adenocarcinoma Arising from Adenofibroma in a Patient with Endometriosis of the Ovary 2015
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organisms 2
noordeloos 2009062
noordeloos 2009062
Source provenance
- europepmc
- last seen: 2026-07-25T06:15:30.875455+00:00
- openalex
- last seen: 2026-06-04T00:00:01.174412+00:00
- pubmed
- last seen: 2026-07-25T06:09:46.810213+00:00
- scilite
- last seen: 2026-05-18T04:57:49.680383+00:00
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