Importance and Surgical Methods of Induction of Endometriosis and Osteoporosis Following Menopause in Rats: an Overview Study

Abolfazl Barzegar-Bafrouei, Moosa Javdani
In: Journal of Shahid Sadoughi University of Medical Sciences · 2022 · doi:10.18502/ssu.v30i5.10155 · W4287958342
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This overview discusses endometriosis and osteoporosis, highlighting rat models involving ovariectomy as valuable tools for understanding and treating these post-menopausal conditions.

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This overview study discusses the importance and surgical methods used to induce endometriosis and osteoporosis following menopause in rat models, focusing on methodological approaches rather than presenting new experimental results. The authors describe how menopause-like conditions in rats are created and how surgical induction procedures can be applied to model endometriosis alongside bone loss. The paper’s key finding is a consolidated account of available surgical induction techniques and their relevance to studying postmenopausal changes in these two conditions. The limitation is that, as an overview, it does not provide original comparative outcomes or quantitative efficacy data for specific surgical methods. This paper is centrally about endometriosis — it provides an overview of surgical methods to induce endometriosis in menopausal rat models and links these methods to osteoporosis after menopause.

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Abstract

Introduction: Endometriosis is one of the main causes of pelvic pain and subfertility, which is characterized by endometrial-like tissues outside the uterus and primarily is created in the pelvic peritoneum, ovaries, walls between the rectum and vagina and in rare cases in the diaphragm, pleura and pericardium. Some risk factors for endometriosis are obstruction in menstrual hemorrhage, an increase in the duration of endogenous estrogen, short menstrual cycles and childbirth at an early age. On the other hand, osteoporosis is a metabolic disease that is determined by bone mineral density and the destruction of the bone microstructure that increases the risk of bone fracture. About 200 million people worldwide are suffering from osteoporosis, that 34% of them are women over 50 years old. The first and most commonly used model for the induction of this disease is the ovariectomy model in rats, which gives a model of the relationship between osteoporosis and menopause. Conclusion: Endometriosis animal models are highly contributing to the development of new non-invasive diagnostic tools and improve therapeutic methods for treatment of endometriosis in women. Although no animal models are absolutely ideal and excellent, but the presence of many similarities in the response of the human skeletal system and rats to reduce estrogen levels and therapeutic compounds caused by the ovariectomy model of the rat, a suitable model for osteoporosis research. The response of rat bones to ovariectomy depends on the type of bone (trabecular against cortical), bone sites (femur, proximal Tibia, and lumbar vertebrae) and it depends on the time elapsed after ovariectomy (the time required to reduce the amount of estrogen levels).
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Publication Journal of Shahid Sadoughi University of Medical Sciences Record type Journal article Published 26 July 2022 Authors Abolfazl Barzegar-Bafrouei | Moosa Javdani The publisher of this work supports multiple resolution. The work is available from the following locations: {'doi': '10.18502/ssu.v30i5.10155', 'member_id': '7770', 'member': 'Knowledge E DMCC', 'container-title': 'Journal of Shahid Sadoughi University of Medical Sciences', 'primary-resource': 'https://publish.kne-publishing.com/index.php/SSU/article/view/10155', 'tld': 'kne-publishing.com', 'clearbit-logo': '/static/no_logo.svg', 'coaccess': [], 'multiple-resolution': [{'url': 'https://jssu.ssu.ac.ir/article-1-5721-en.html', 'tld': 'ssu.ac.ir', 'clearbit-logo': '/static/no_logo.svg'}, {'url': 'https://publish.kne-publishing.com/index.php/SSU/article/view/10155', 'tld': 'kne-publishing.com', 'clearbit-logo': '/static/no_logo.svg'}], 'type': 'JOURNAL ARTICLE', 'published_date': '26 July 2022', 'publication': 'Journal of Shahid Sadoughi University of Medical Sciences', 'title': 'Importance and Surgical Methods of Induction of Endometriosis and Osteoporosis Following Menopause in Rats: an Overview Study', 'name': None, 'id': None, 'location': None, 'display_doi': 'https://doi.org/10.18502/ssu.v30i5.10155', 'grant_info': None, 'grant_info_funders': None, 'grant_info_funder_ids': '', 'grant_info_type': None, 'multiple_lead_investigators': [], 'multiple_co_lead_investigators': [], 'multiple_investigators': [], 'finances': [], 'project_description': None, 'award_amount': None, 'award_start': None, 'funding_scheme': None, 'internal_award_number': None, 'editors': None, 'authors': 'Abolfazl Barzegar-Bafrouei | Moosa Javdani', 'chairs': None, 'supplementary_ids': None} https://doi.org/10.18502/ssu.v30i5.10155 JSON XML

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