Analysis of the efficacy of LNSRH for early cervical cancer based on T, B and NK lymphocytes

Objective: The analysis is based on the analysis of T, B, NK lymphocytes to analyze the efficacy of LNSRH surgery in the treatment of early cervical cancer. Methods: This article selected 30 patients with early cervical cancer who underwent LNSRH surgery in our hospital from December 2019 to January 2021 as the cervical cancer group, and 30 healthy women who underwent physical examination in our hospital during the same period were selected as the control group. The expressions of CD 4 + , CD 8 + , CD 20 + , and CD 57 + were detected by flow cytometry, FSFI, FACT-G scores were used to evaluate female sexual function and quality of life, and the receiver characteristic curve (ROC) was used to analyze the expression of CD 4 + , CD 8 + , CD 20 + , and CD 57 + in LNSRH surgery The predictive value of curative effect in the treatment of early cervical cancer. Results: The expression of CD 4 + and CD 57 + in the cervical cancer group was lower than that in the healthy group, and the expression of CD 8 + and CD 20 + was higher than that in the healthy group ( P <0.05). Compared with preoperatively, the expression of CD 4 + and CD 57 + was higher after operation, and the expression of CD 8 + and CD 20 + was lower ( P <0.05); compared with 1 day after operation, the expression of CD 4 + and CD 57 + was higher at 3d postoperatively, and the expression of CD 8 + and CD 20 + was lower ( P <0.05). CD 4 + , CD 57 + expression was positively correlated with FSFI score, CD 8 + , CD 20 + expression was negatively correlated with FSFI score, CD 4 + , CD 57 + expression was positively correlated with FACT-G score, and CD 8 + , CD 20 + expression was negatively correlated with FACT-G score ( P <0.05) . ROC analysis of CD 4 + , CD 8 + , CD 20 + , CD 57 + expression sensitivity was lower than the four-item combination, and the specificity was higher than the four-item combination, with statistical difference ( P <0.05). The four combined tests have good predictive value for the efficacy of LNSRH surgery in the treatment of early cervical cancer ( P ＜0.05). Conclusion: Cervical cancer patients are mainly cellular immunity. Cervical cancer patients have low expression of CD 4 + , high expression of CD 8 + , high expression of CD 20 + , and low expression of CD 57 + . T, B, and NK lymphocytes can be used for immunological detection of cervical cancer.