The expression of matrix metallop roteinase-2,3 and tissue inhibitor of metalloproteinase-1 in endometriosis
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Immunohistochemical analysis revealed that ectopic endometriotic tissue exhibits higher MMP-2 and MMP-3 levels but lower TIMP-1 expression compared to normal uterine endometrium, with no significant differences observed between endometriosis and adenomyosis groups.
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Abstract
Objective: To investigate the role of matrix metalloproteinase-2,3 and tissue inhibitor of metalloproteinase-1 in the pathogenesis endometriosis.Methods:Immunohistochemical method(SP) was employed to detect the expression of MMP2,3 and TIMP-1 in ectopic endometriotic tissue from women with endometriosis(60 cases) and with adenomyosis(40 cases) and the normal controls(30 cases).Results:The expressions of MMP-2,MMP-3 in ectopic endometriotic tissue were higher than those of uterine endometrium from women without endometrosis(P0.05).The expression of TIMP-1 in ectopic endometriotic tissue were lower than those of uterine endometrium from women without endometrosis(P0.05).The expressions of MMP2,MMP-3,TIMP-1 were no obvious difference between the ectopic endometriotic tissue from women with endometriosis and with adenomyosis(P0.05).Conclusion:The increased expression of MMP-2,3 and decrease expression of TIMP-1 in the ectopic endometriotic tissue contributes to the pathogenosis of endometriosis.
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