Antibiotic “Timeout” on Electronic Prescribing - Impact of Antibiotic Hardstop on Antimicrobial Stewardship Initiatives

Background: Antimicrobial resistance (AMR) remains a major public health threat and the exploration of interventions which may reduce inappropriate antimicrobial use are of particular interest. An Antibiotic Timeout (ATO) was included within the electronic medicine (eMeds) system introduced to the Central Coast Local Health District (CCLHD) in 2018. The function allows prescribers to set a predetermined time at which antibiotic orders would cease. By default, the function set prescribed length to 5 days with a view to encourage prescribers to review existing antimicrobial orders and reduce inappropriate use. Methods: : Records of adult inpatients prescribed broad spectrum antimicrobials with a registered indication of community acquired pneumonia (CAP) or an infective exacerbation of chronic obstructive pulmonary disease (IECOPD) between the 1 st of March 2017 and 31st May 2017 for the pre eMeds cohort and 1 st March 2019 and 31st May 2019 for the post eMeds cohort were randomly selected from our local health network’s Guidance MS® system. Baseline demographics, antimicrobial prescribing records and documented adverse events related to the antibiotic timeout function were collated/analysed. The days of therapy (DOT) and length of therapy (LOT) for each encounter were calculated manually and results analysed using a two-tailed t-test or Mann-Whitney U test. Results: : Of patients eligible to have the ATO function activated during their admission, 34% (n=34) had the function deployed at least once. Following the introduction of eMeds mean DOT for the pooled indications cohort was reduced by 3.02 days (CI 95% 0.41 – 5.63, p<0.05) and mean LOT by 1.97 days (CI 95% 0.39 – 3.55, p<0.05). The timeout function resulted in 2 cases of delayed or unintentionally ceased therapies. Conclusions: : Following the introduction of electronic prescribing and ATO, a significant reduction was observed in the DOT and LOT for antimicrobial use for inpatients with CAP and IECOPD without a significant increase in adverse events. Further research is required to determine the extent to which the antibiotic timeout functionality directly contributed to this effect and if the effect is present across a broader range of indications.