[Research advances on the role of mast cells in pelvic pain of endometriosis].

Libo Zhu, Xinmei Zhang
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2013 · vol. 42(4) , pp. 461–3 · doi:10.3785/j.issn.1008-9292.2013.04.015 · PMID:24022937 · W314017668
review OA: closed CC0 ⤵ 1 in-corpus citation
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⚙ AI-generated summary by claude@2026-06, 2026-06-13 ⓘ

Mast cells contribute to endometriosis pain by releasing inflammatory mediators in response to neural peptides released from nerve fibers in lesions.

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The provided text contains only the journal website/navigation content for a paper titled about the role of mast cells in pelvic pain of endometriosis, with no study details, population, methods, results, or explicit limitations included. Because the actual paper body is not present, the key findings and any caveats stated by the authors cannot be determined from the supplied material. This paper is centrally about endometriosis — the paper’s title indicates a focus on mast cells and pelvic pain in endometriosis.

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Abstract

Endometriosis (EMs) is a common gynecologic disease that affects women's physical and mental health seriously. The pathogenesis is still unknown and the mechanism of endometriosis-associated pain remains unclear. Mast cells (MC) are known to be multifunctional players in the immune system. Recent studies have shown that nerve fibers in EMs lesions can release neural peptides such as nerve growth factor and substance P to induce MC degranulating and releasing histamine, proteases, cytokines, chemokines etc., which contributes to the development of pain and hyperalgesia in patients with endometriosis.
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Condition tags

endometriosischronic_pelvic_pain

MeSH descriptors

Endometriosis Endometriosis Mast Cells Pelvic Pain Endometriosis Endometriosis Female Humans Mast Cells Nerve Growth Factor Nerve Growth Factor Pelvic Pain Pelvic Pain

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europepmc
last seen: 2026-06-18T06:15:08.409253+00:00
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