Elevated Neuron Spesific Enolase Levels in Post-traumatic Stress Disorder

Abstract Neuron spesific enolase (NSE) is a biomarker indicative neuronal cell damage. The aim of this study is to assess the NSE levels in patients diagnosed with post-traumatic stress disorder (PTSD) and major depressive disorder (MDD). Blood samples were collected from 43 individuals with PTSD (age range: 11–17), 43 individuals with MDD (age range: 10–17), and 40 age- and gender-matched healthy controls. The NSE levels were analyzed, and participants completed the Post-traumatic Stress Reaction Index, the Children's Depression Inventory, and the Screen for Child Anxiety Related Disorders. Additionally, the Clinical Global Impressions Scale was filled out by the researcher. Results indicated that the NSE levels in the PTSD group were significantly higher than those in both the MDD group and the healthy control group. No significant difference in NSE levels was observed between the MDD group and the healthy control group. The elevated NSE levels in the PTSD group suggest a potential association with neuronal pathology development following severe stress. The lack of significant difference in NSE levels between the MDD and control groups suggests that trauma may have a more pronounced impact on neuronal structures. These findings contribute to the existing literature on the biological effects of PTSD and MDD.