Intravenous lidocaine Increases the Efficacy of Propofol Anesthesia for Gastroscope Implanted:A Randomised, Double-blind, Controlled Study

Intravenous lidocaine Increases the Efficacy of Propofol Anesthesia for Gastroscope Implanted:A Randomised, Double-blind, Controlled Study | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Intravenous lidocaine Increases the Efficacy of Propofol Anesthesia for Gastroscope Implanted:A Randomised, Double-blind, Controlled Study Fu Shi, Jie Chen, Guang Ren, Rong Du, Xiang Wang This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-149394/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Backgroud : Gastroscope insertion is a distressing experience and propofol use for sedation can result in inhibition of circulation and respiration. Intravenous (IV) infusion of lidocaine has been shown to reduce propofol requirements during surgery.The goal of this study was to evaluate the impact of IV lidocaine on the median effective dose (ED50) of propofol and other outcomes after surgery. Method : Ninety adult patients undergoing analgesic gastroscopy were randomly divided into two groups (45 cases in each). The lidocaine group was slowly injected with 1% lidocaine at 1.5mg/kg while the saline group was given the same volume of saline before propofol induction. Motion and cough reaction were regarded as the judgment index of gastroscope implanted. The dose-response curves were made in the two groups when implanted gastroscope according to the formula of Y=Ymin+(Ymax-Ymin)/[1+10 log(ED50-X)*m ]. The primary outcome were the ED50 and requirement of propofol. Secondary outcomes were:intraoperative hemodynamic parameters,adverse reaction,awakening time,post-operative pain and fatigue. Results : Compared with the group S, the dose-response curve showing percentage of gastroscope implanted after propofol anesthesia in the L group shifted to the left. Intravenous infusion of lidocaine decreased the ED50 of propofol (group S 1.80mg/kg, group L 1.56mg/kg).Compared with group S, induction, additional requirement and total dose of propofol anesthesia, and incidence of bucking were significantly reduced in group L (P<0.05). Post-operative fatigue scores in group L were lower than that in group S (P < 0.05). Conclusion : Intravenous lidocaine could reduce the consumption of propofol anesthesia and reduce adverse reaction in patients undergoing painless gastroscopy. Trials registration: ChiCTR2000038542. Data of registration: Sep 23th, 2020. Anesthesiology & Pain Medicine Intravenous lidocaine Propofol Gastroscopy The median effective dose Figures Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Full Text Due to technical limitations, full-text HTML conversion of this manuscript could not be completed. However, the latest manuscript can be downloaded and accessed as a PDF. Additional Declarations No competing interests reported. Supplementary Files database.xls CONSORT2010Checklist.doc researchprotocol.doc Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-149394","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":10852106,"identity":"04836415-5634-482e-aba5-4849807fce61","order_by":0,"name":"Fu Shi","email":"","orcid":"","institution":"Department of Anesthesiology, Liaocheng People's Hospital","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Fu","middleName":"","lastName":"Shi","suffix":""},{"id":10852108,"identity":"87f1233d-207b-4623-8a89-f0c616a04ee8","order_by":1,"name":"Jie Chen","email":"","orcid":"","institution":"Department of Anesthesiology, Liaocheng People's Hospital","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Jie","middleName":"","lastName":"Chen","suffix":""},{"id":10852110,"identity":"818b8108-fb9b-4f97-bd30-2c371fe0aaca","order_by":2,"name":"Guang Ren","email":"","orcid":"","institution":"Department of Anesthesiology, Liaocheng People's Hospital","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Guang","middleName":"","lastName":"Ren","suffix":""},{"id":10852111,"identity":"523a82bd-e86d-4d49-8513-4bd62316b003","order_by":3,"name":"Rong Du","email":"","orcid":"","institution":"Department of Anesthesiology, Liaocheng People's Hospital","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Rong","middleName":"","lastName":"Du","suffix":""},{"id":10852112,"identity":"b0542db1-6e4b-4d1e-8bb6-043e003d94bd","order_by":4,"name":"Xiang Wang","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAAs0lEQVRIiWNgGAWjYHACxgNAQo6BmRQ9IC3GpGtJbCBaucGNHIPDvDl16fPbeQ9+YKixiSas5cyxhMO829hyNxzmS5ZgOJaWS9A6s+PNB4BaeHI3MPMYSDA2HCZCy2GgMt5tEunyzTzGP4jTArHFIIHhMI8ZcbbYA/1ycO62BMMNQC0WCcT4RXJGjuGDt9vq5OX7zxjf+FBjQ1gLCDDxwFgJxCgHAcYfxKocBaNgFIyCkQkANwc+NSvEhFkAAAAASUVORK5CYII=","orcid":"","institution":"Department of Anesthesiology, Liaocheng People's Hospital","correspondingAuthor":true,"submittingAuthor":false,"prefix":"","firstName":"Xiang","middleName":"","lastName":"Wang","suffix":""}],"badges":[],"createdAt":"2021-01-17 13:43:59","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-149394/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-149394/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":5780906,"identity":"fc853a07-2ad5-45f6-8dce-9f8f01214469","added_by":"auto","created_at":"2021-02-09 15:16:31","extension":"png","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":90644,"visible":true,"origin":"","legend":"study population flow diagram","description":"","filename":"figure1.png","url":"https://assets-eu.researchsquare.com/files/rs-149394/v1/584f0bf7b2ec53c9f68d65d5.png"},{"id":5780908,"identity":"9a8b7680-0f65-401e-a208-8b03303360ab","added_by":"auto","created_at":"2021-02-09 15:16:31","extension":"png","order_by":2,"title":"Figure 2","display":"","copyAsset":false,"role":"figure","size":122286,"visible":true,"origin":"","legend":"A:The dose-response curves of gastroscopy implanted under propofol anesthsia X axle shown the log-converted drug dose using the Prism 5 software, Y axle shown the percentage of\n \ngastroscope implanted at different dose of propofol anesthesia. B: the induction, additional and total consumption dose of propofol in the two groups.\n","description":"","filename":"figure2.png","url":"https://assets-eu.researchsquare.com/files/rs-149394/v1/87ad5acc16fec3c436e61318.png"},{"id":5780733,"identity":"042f8ff8-4d08-4758-9e09-f8b2056b9088","added_by":"auto","created_at":"2021-02-09 15:13:31","extension":"png","order_by":3,"title":"Figure 3","display":"","copyAsset":false,"role":"figure","size":82816,"visible":true,"origin":"","legend":"Comparison of MAP and HR at different time points in the two groups\n\nNotes: T0= before induction ; T1= after anesthesia induction ; T2=after endoscope implantation; T3 =after endoscope removal. * P ＜ 0.05,compared with saline group\n","description":"","filename":"figure3.png","url":"https://assets-eu.researchsquare.com/files/rs-149394/v1/0f84806a3bf39735cbed7909.png"},{"id":5780735,"identity":"20687615-5cbc-4b72-96d1-7193988a0283","added_by":"auto","created_at":"2021-02-09 15:13:31","extension":"png","order_by":4,"title":"Figure 4","display":"","copyAsset":false,"role":"figure","size":130790,"visible":true,"origin":"","legend":"Comparison of the adverse reaction between the two groups during the surgery Note: Grey color shown the percentage of adverse reaction in the two groups.","description":"","filename":"figure4.png","url":"https://assets-eu.researchsquare.com/files/rs-149394/v1/13f02ed383eba2573f712d2f.png"},{"id":5780907,"identity":"44785517-31eb-49f0-8cfd-8137e70d3f48","added_by":"auto","created_at":"2021-02-09 15:16:31","extension":"png","order_by":5,"title":"Figure 5","display":"","copyAsset":false,"role":"figure","size":72445,"visible":true,"origin":"","legend":"Comparison of the recovery time, pain and fatigue score in the two groups * P ＜ 0.05; compared with saline group","description":"","filename":"figure5.png","url":"https://assets-eu.researchsquare.com/files/rs-149394/v1/7f8b2485685dac2f36f9f725.png"},{"id":13582401,"identity":"b7f4266a-f9a7-4aed-9fc8-329951106479","added_by":"auto","created_at":"2021-09-17 04:31:01","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":1282204,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-149394/v1_covered.pdf"},{"id":5781070,"identity":"ec8cdafd-25e7-4fa3-b21a-591d71364c6b","added_by":"auto","created_at":"2021-02-09 15:22:35","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":1029316,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-149394/v1_stamped.pdf"},{"id":5781022,"identity":"6da67b17-5b89-4f69-b56f-c1db4cfece13","added_by":"auto","created_at":"2021-02-09 15:19:31","extension":"xls","order_by":1,"title":"","display":"","copyAsset":false,"role":"supplement","size":46592,"visible":true,"origin":"","legend":"","description":"","filename":"database.xls","url":"https://assets-eu.researchsquare.com/files/rs-149394/v1/4051a3c49bb07efe3cdfc88a.xls"},{"id":5780741,"identity":"780d1e78-8e11-42ab-a99b-fd9ea3085511","added_by":"auto","created_at":"2021-02-09 15:13:31","extension":"doc","order_by":2,"title":"","display":"","copyAsset":false,"role":"supplement","size":200704,"visible":true,"origin":"","legend":"","description":"","filename":"CONSORT2010Checklist.doc","url":"https://assets-eu.researchsquare.com/files/rs-149394/v1/286287e91c0a68c624a98660.doc"},{"id":5780909,"identity":"2df5d271-9eb6-4ebc-be68-cc150662df1b","added_by":"auto","created_at":"2021-02-09 15:16:31","extension":"doc","order_by":3,"title":"","display":"","copyAsset":false,"role":"supplement","size":39744,"visible":true,"origin":"","legend":"","description":"","filename":"researchprotocol.doc","url":"https://assets-eu.researchsquare.com/files/rs-149394/v1/c65537483c458268d0cc513d.doc"}],"financialInterests":"No competing interests reported.","formattedTitle":"\u003cp\u003eIntravenous lidocaine Increases the Efficacy of Propofol Anesthesia for Gastroscope Implanted:A Randomised, Double-blind, Controlled Study\u003c/p\u003e","fulltext":[{"header":"Full Text","content":"Due to technical limitations, full-text HTML conversion of this manuscript could not be completed. However, the latest manuscript can be downloaded and \u003ca href='/article/rs-149394/latest.pdf' target='_blank'\u003e accessed as a PDF.\u003c/a\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Intravenous lidocaine, Propofol, Gastroscopy, The median effective dose","lastPublishedDoi":"10.21203/rs.3.rs-149394/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-149394/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cstrong\u003eBackgroud\u003c/strong\u003e: Gastroscope insertion is a distressing experience and propofol use for sedation can result in inhibition of circulation and respiration. Intravenous (IV) infusion of lidocaine has been shown to reduce propofol requirements during surgery.The goal of this study was to evaluate the impact of IV lidocaine on the median effective dose (ED50) of propofol and other outcomes after surgery. \u003c/p\u003e\u003cp\u003e\u003cstrong\u003eMethod\u003c/strong\u003e: Ninety adult patients undergoing analgesic gastroscopy were randomly divided into two groups (45 cases in each). The lidocaine group was slowly injected with 1% lidocaine at 1.5mg/kg while the saline group was given the same volume of saline before propofol induction. Motion and cough reaction were regarded as the judgment index of gastroscope implanted. The dose-response curves were made in the two groups when implanted gastroscope according to the formula of Y=Ymin+(Ymax-Ymin)/[1+10 log(ED50-X)*m ]. The primary outcome were the ED50 and requirement of propofol. Secondary outcomes were:intraoperative hemodynamic parameters,adverse reaction,awakening time,post-operative pain and fatigue. \u003c/p\u003e\u003cp\u003e\u003cstrong\u003eResults\u003c/strong\u003e: Compared with the group S, the dose-response curve showing percentage of gastroscope implanted after propofol anesthesia in the L group shifted to the left. Intravenous infusion of lidocaine decreased the ED50 of propofol (group S 1.80mg/kg, group L 1.56mg/kg).Compared with group S, induction, additional requirement and total dose of propofol anesthesia, and incidence of bucking were significantly reduced in group L (P\u0026lt;0.05). Post-operative fatigue scores in group L were lower than that in group S (P \u0026lt; 0.05). \u003c/p\u003e\u003cp\u003e\u003cstrong\u003eConclusion\u003c/strong\u003e: Intravenous lidocaine could reduce the consumption of propofol anesthesia and reduce adverse reaction in patients undergoing painless gastroscopy. Trials registration: ChiCTR2000038542. 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