A photo-Responsive Porphyrin-Mn@Choles Complex for Bacteria Treatment

Abstract Biocompatible photo-driven producers of singlet oxygen can inhibit the growth of drug-resistant bacteria and tumors. In order to bacteria targeting generator of singlet oxygen for tumor and bacterial treatment, a metal porphyrin liposome (Phy-Mn-Ls) was prepared by the metal coordination reaction and self-assembly of porphyrin compounds with bacteria targeting polymer (HS-PEG-chol). The photo-driven production of 1O2, binding with protein (BSA) and lipase, toxicity to MCF-7 breast cancer cells and inhibitory effect on the growth of Escherichia coli were investigated. Fluorescence analysis results show that Phy-Mn-Ls can bind to lipase, and it shows less effect on the conformation of BSA and is low cytotoxicity without irradiation. In particular, the good biocompatibility made Phy-Mn-Ls exhibit good photosensitive antibacterial activity and anti-tumor properties. The results demonstrate that the coordination of HS-PEG-chol with metal-phorphrin coodination is an effective way to develop bacteria targeting nano-complexes (Phy-Mn-Ls) for lipase affinity and photodriven bacteria treatment.