Tibolone Use Associated With Elevated Hepatocellular Carcinoma Risk: Findings From a Nationwide Cohort.

Lee J, Kim HJ, Park SJ, Park S, Chung J, Yu J, Kang JH, Jeong S, Shin HY, Park SM
International journal of cancer · 2027 · doi:10.1002/ijc.70725 · PMID:42681541 · PMC13729920
Observational OA: gold
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Abstract

Tibolone, a synthetic steroid with estrogenic, progestogenic, and androgenic activity, is widely prescribed for menopausal symptoms, but its association with hepatocellular carcinoma (HCC) remains unclear. Using data from 117,271 women aged ≥ 45 years in the Korean National Health Insurance Service-Health Screening Cohort, we evaluated tibolone use between 2003 and 2007 and identified incident HCC from 2009 through 2019, implementing a 1-year lag period. Participants were propensity score-matched (1:10) by demographic, lifestyle, and metabolic factors. During a median 11-year follow-up, women with ≥ 180 cumulative days of tibolone use showed a higher HCC risk compared with non-users (hazard ratio [HR], 1.88; 95% CI, 1.07-3.29), which persisted after adjustment for key covariates (adjusted hazard ratio [aHR], 1.74; 95% CI, 0.99-3.06). A dose-response trend was observed (P for trend = 0.043). These findings suggest a possible link between sustained tibolone use and HCC risk, warranting confirmation in larger populations and longer follow-up, ideally through well-designed prospective studies.

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organisms 10
noordeloos 2009062 noordeloos 2009062 men 2004071 noordeloos 2009062 noordeloos 2009062 woodchuck hepatitis virus rodents noordeloos 2009062 noordeloos 2009062 noordeloos 2009062
chemicals 48
estrogen progestogen estrogen estrogen tibolone tibolone steroid tibolone tibolone tibolone tibolone tibolone tibolone tibolone clopidogrel alcohol glucose cholesterol tibolone tibolone tibolone tibolone tibolone clopidogrel tibolone tibolone tibolone tibolone estrogen tibolone tibolone tibolone tibolone tibolone tibolone tibolone tibolone tibolone tibolone tibolone tibolone tibolone tibolone tibolone steroid tibolone tibolone tibolone

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