Proteomische Methoden zur Diagnostik der Endometriose aus Patientenserum

The study investigated whether proteomic profiling of patient serum using SELDI-TOF mass spectrometry could distinguish women with endometriosis from those without, in a prospective exploratory cohort of 91 symptomatic reproductive-age women undergoing laparoscopy for chronic pelvic pain, dysmenorrhea, dyspareunia, or infertility. Serum proteins were applied to Q10 or CM10 ProteinChip surfaces, and analysis using Ciphergen ProteinChip 3.1 and Bruker ClinProTools 2.0 identified endometriosis-associated mass peak patterns between 2 and 18 kDa, achieving an overall recognition capability of 86.3% with sensitivity 66.7% and specificity 46.0%. A key limitation is the preliminary nature of the findings and the modest specificity, meaning discrimination is imperfect. This paper is centrally about endometriosis — it evaluates SELDI-TOF–based serum proteomic markers to detect endometriosis in symptomatic women prior to or around diagnostic laparoscopy.

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