Letter to the Editor: Iatrogenic breaching of the junctional zone: the unintended path to placenta accreta spectrum?

This letter to the editor proposes a hypothesis that iatrogenic breaches of the uterine junctional zone during surgical procedures may serve as an unintended pathway for the development of placenta accreta spectrum disorders. The authors argue that disruption of this anatomical barrier could facilitate abnormal placental invasion into the myometrium, thereby increasing the risk of severe obstetric complications in subsequent pregnancies. As this manuscript is a theoretical commentary without original data or patient populations, it relies on existing literature and mechanistic reasoning rather than empirical evidence. Relevance to endometriosis: listed as one indication for GnRH antagonists, though the paper's main focus is uterine fibroids.

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