Serous cystadenofibroma of ovary mimicking malignancy: a case report and review of diagnostic challenges

B. Kalpana, Abhinav B. Anand, Aishwina Anand, S. Balamurugan
In: International Journal of Reproduction, Contraception, Obstetrics and Gynecology · 2025 · vol. 14(10) , pp. 3574–3576 · doi:10.18203/2320-1770.ijrcog20253113 · W4414556568
article OA: diamond CC0
🔓 Open OA copy Full text JSON View on OpenAlex View at publisher
⚙ AI-generated deep summary by claude@2026-07, 2026-07-03 · read from full text ⓘ

This case report describes a 31-year-old nulliparous woman with heavy menstrual bleeding, in whom imaging identified a complex multiloculated right ovarian cyst (~5 cm) and led to a provisional diagnosis of a complex ovarian neoplasm mimicking malignancy. She underwent right ovarian cystectomy, and histopathological examination confirmed a benign serous cystadenofibroma. The authors emphasize that this rare benign epithelial tumor can display imaging features that resemble malignant ovarian tumors, creating diagnostic challenges. This paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

Ovarian cystadenofibroma is a rare benign epithelial tumour composed of both glandular and fibrous stromal elements. Although benign, its imaging features mimic those of malignant neoplasms, posing diagnostic and therapeutic challenges. We report a case of 31-year-old nulliparous woman who presented with heavy menstrual bleeding. Clinical examination revealed right adnexal fullness and imaging studies demonstrated a complex multiloculated right ovarian cyst measuring approximately 5cm. a provisional diagnosis of complex ovarian neoplasm was made. Patient underwent right ovarian cystectomy. Histopathological examination confirmed the diagnosis of benign serous cystadenofibroma.
Full text 2,372 characters · extracted from oa-doi-fallback · click to expand
Serous cystadenofibroma of ovary mimicking malignancy: a case report and review of diagnostic challenges DOI: https://doi.org/10.18203/2320-1770.ijrcog20253113Keywords: Serous cystadenofibroma, Histopathological examination, Ovary mimicking malignancyAbstract Ovarian cystadenofibroma is a rare benign epithelial tumour composed of both glandular and fibrous stromal elements. Although benign, its imaging features mimic those of malignant neoplasms, posing diagnostic and therapeutic challenges. We report a case of 31-year-old nulliparous woman who presented with heavy menstrual bleeding. Clinical examination revealed right adnexal fullness and imaging studies demonstrated a complex multiloculated right ovarian cyst measuring approximately 5cm. a provisional diagnosis of complex ovarian neoplasm was made. Patient underwent right ovarian cystectomy. Histopathological examination confirmed the diagnosis of benign serous cystadenofibroma. Metrics References Lheureux S, Braunstein M, Oza AM. Epithelial ovarian cancer: Evolution of management in the era of precision medicine. CA Cancer J Clin. 2019;69(4):280-304. DOI: https://doi.org/10.3322/caac.21559 Leelavathi, Roy P, Sree SG, Srirama S. Ovarian serous cystadenofibroma – A rare case report. J South Asian Feder Obst Gynae. 2015;7(2):112–4. DOI: https://doi.org/10.5958/2394-2754.2015.00033.8 Bencherifi Y, Watik F, Lyafi Y, Mostapha B, Ennachit M, Mohammed EK. Serous ovarian cystadenofibroma and review of the literature: Report of a case. Int J Surg Case Rep. 2023;110:108649. DOI: https://doi.org/10.1016/j.ijscr.2023.108649 Montoriol P-F, Mons A, Da Ines D, Bourdel N, Tixier L, Garcier JM. Fibrous tumours of the ovary: Aetiologies and MRI features. Clin Radiol. 2013;68(12):1276–83. DOI: https://doi.org/10.1016/j.crad.2013.07.005 Wolfe SA, Seckinger DL, Variedanatomical types of ovarianadenofibroma. A proposed classification. Am. J. Obstet. Gynecol. 1967;99:121–5. DOI: https://doi.org/10.1016/S0002-9378(16)34500-8 Sivapragasam V, Nellore L. Serous papillary cystadenofibroma of ovary with extremely elevated CA 125. A masquerader of malignancy: a case report. J South Asian Feder Obst Gynae. 2024;16(1):692. DOI: https://doi.org/10.5005/jp-journals-10006-2387 Bell D.A., Scully R.E. Atypical and borderline endometrioidadenofibromas of the ovary. A report of 27 cases. Am J Surg Pathol. 1985;1:87.

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: oa-doi-fallback ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Citation neighborhood (no data yet)

We don't have any in-corpus citations linked to this paper yet. This is a recent paper (2025) — citers typically take a year or two to land, and the OpenAlex reference graph may still be filling in.

References (6)

Source provenance

openalex
last seen: 2026-05-14T06:16:37.095483+00:00
License: CC0 · commercial use OK