Efficacy of Gonadotropin- releasing Hormone Agonist Combined with Desogestrel- ethinylestradiol for Treating Severe Endometriosis

Objective To investigate the clinical efficacy of gonadotropin- releasing hormone agonist( GnRH- a)combined with desogestrel- ethinylestradiol for treating severe endometriosis.Methods A total of 80 patients with severe endometriosis who were admitted to our hospital and were treated by laparoscopic conservative operation from January 2009 to May2012,were selected as study subjects.The patients were randomly divided into two groups: control group( 38 cases) received GnRH- a treatment alone after operation,while observation group( 42 patients) were given the treatment of GnRH- a combined Marvelon after operation.The patients were followed up for 1 year,levels of the endocrine hormones( FSH,LH,E2),severity of perimenopausal period syndrome( Kupperman score) and patients' subjective feelings for perimenopausal period syndrome were compared between two groups of patients before operation and in 1 year after operation.Results There was no significant difference in levels of FSH,LH and E2 between two groups of patients before operation( P 0.05).For both groups,levels of FSH,LH and E2 after operation were significantly lower than those before operation( P 0.05),there was no significant difference in levels of FSH,LH and E2 between two groups of patients in 1 year after surgery( P 0.05).There was no significant difference in hot flushes and sweating score,vulvovaginal discomfort score,joint pain score and Kupperman score between two groups of patients before operation( P 0.05).The vulvovaginal discomfort score and Kupperman score in observation group were significant lower than those in control group 〔( 1.1 ± 1.0) vs.( 2.0 ± 1.5),( 9.0 ± 1.2) vs.( 10.5 ± 1.3),P 0.05〕in 1 year after surgery.There was no significant difference in hot flushes and sweating score and joint pain score between two groups in 1 year after surgery( P 0.05).There was no significant difference in dysmenorrhea score,chronic pelvic pain score,dyspareunia score and subjective feelings total score between two groups of patients before operation( P 0.05).The chronic pelvic pain score and subjective feelings total score in observation group were significant lower than those in control group in 1 year after surgery 〔( 0.20 ± 0.32) vs.( 0.40 ± 0.53),( 2.53 ± 1.21) vs.( 3.47 ± 1.31),P 0.05〕.There was no significant difference in dysmenorrhea score and dyspareunia score between two groups in 1 year after surgery( P≥0.05).Conclusion Marvelon can relieve the low level estrogen- related symptoms caused by GnRH- a treatment among patients with severe endometriosis,and can relieve pain symptom caused by endometriosis.