Diminished ovarian reserve in patients with psoriasis

Burcu Tuğrul Ayanoğlu, Elif Didem Özdemir, Elif Özdemir, Onur Türkoğlu, Aslıhan Alhan
Taiwanese journal of obstetrics & gynecology · 2018 · vol. 57(2) , pp. 227–230 · doi:10.1016/j.tjog.2018.02.010 · PMID:29673665 · W2799447821
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This study found that female patients with psoriasis exhibit significantly higher follicle-stimulating hormone levels and lower antral follicular counts than healthy controls, indicating diminished ovarian reserve unrelated to disease severity.

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Abstract

OBJECTIVE: Psoriasis is a multi-systemic chronic inflammatory skin disease. Previous data suggests that women with some chronic inflammatory diseases have diminished ovarian reserve. This study explores ovarian reserve in patients with psoriasis. MATERIALS AND METHODS: We prospectively analyzed 14 female patients with psoriasis and 35 healthy age and body mass index matched controls. An interview explored demographic characteristics, obstetrical history and menstrual characteristics. Psoriatic area severity index (PASI) in patients was assessed. Estrogen, follicle-stimulating hormone (FSH), luteinizing hormone (LH), thyroid stimulating hormone and with gynecologic ultrasonography, ovarian volume and antral follicular count (AFC) were measured in both study and control groups. These values were analyzed with changes of the PASI in the patient group. RESULTS: Patients with psoriasis had significantly higher levels of FSH and FSH/LH ratio than healthy controls (p = 0.039, p = 0.005 respectively). AFC of psoriasis patients were significantly lower than healthy controls (p = 0.002).There were no significant difference among other hormone levels and ovarian volumes (p > 0.05). The hormone levels, ovarian volume and AFC were not correlated with PASI of the patients. CONCLUSION: The results of the study suggest that patients with psoriasis may have diminished ovarian reserve.

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MeSH descriptors

Ovarian Reserve Psoriasis Adolescent Adult Estradiol Estradiol Female Follicle Stimulating Hormone Follicle Stimulating Hormone Humans Luteinizing Hormone Luteinizing Hormone Middle Aged Ovarian Follicle Ovarian Follicle Ovary Ovary Prospective Studies Psoriasis Psoriasis

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