자궁내막증 환자의 복강액의 Interleukin-8에 관한 연구

Objective : This study was investigated to know the relationship between the level of interleukin-8(IL-8) in the peritoneal fluid of women with and without endometriosis Design : Prospective and case-control study. Setting : University hospital. Patients : Twenty six patients who had been confirmed endometriosis by operative and pathological findings were studied. The another twenty six women with benign gynecologic disease except endometriosis was studied by control groups. Main outcome and Measures : IL-8 levels in peritoneal were determined using commercial ELISA set. IL-8 concentration were compared between women with and without endometriosis, and also compared according to severity of endometriosis by which was graded the revised American Fertility Society classification. Results : IL-8 concentration was higher in the peritoneal fluid of women with endometriosis than in matched controls. The concentrations in the proliferative phase were higher than those in the secretory phase. IL-8 concentration in endometriosis stage III, IV were significant higher than stage I, II. Conclusions : Increased level of IL-8 in peritoneal fluid of patients with endometriosis may be related to the pathogenesis of endometriosis that partially contribute to the disturbed immune response.