The use of platelet rich plasma in the management of medication-related osteonecrosis of the jaws: a cohort study

Medication-related osteonecrosis of the jaw (MRONJ) is an adverse drug reaction that occurs in a very different ways and affects patients with complex medical histories.  The objective of this study is to evaluate the prognosis of surgically treated drug-related osteonecrotic lesions and to verify whether the platelet concentrates used during the surgical procedure can improve the prognosis. The study was performed by analyzing a sample of 64 patients with medication-related osteonecrosis of the maxillary bones, in which 79 lesions were diagnosed and surgically treated at the S. Orsola-Malpighi Polyclinic in Bologna.  The lesions treated with PRP showed a lower tendency to relapse compared to its non-use, the probability of recurrence.  In conclusion, this study demonstrates that treatment with PRP may have positive effects in the therapy of Medication-Related Osteonecrosis of the Jaw (MRONJ).