Hollow mesoporous silica nano-delivery systems based on ultra-thin biodegradable shells a synergistic integration strategy for chemotherapy and photothermal therapy

Hollow mesoporous silica nano-delivery systems based on ultra-thin biodegradable shells a synergistic integration strategy for chemotherapy and photothermal therapy | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Hollow mesoporous silica nano-delivery systems based on ultra-thin biodegradable shells a synergistic integration strategy for chemotherapy and photothermal therapy Huixia Zhang, Yan Zhang, Zhencheng Diao, Minmin Chen, Xichuan Cao This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-6485418/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Mesoporous silica nanoparticles (MSNs) have been discovered to hold substantial potential in tumor treatment due to their ability to enhance drug tumor-targeting capacity and reduce side effects as a nanoparticle drug delivery system. We rationally designed and successfully synthesized hollow mesoporous silica nanoparticles (HMSNs) with a large cavity structure and ultra-thin shells. By incorporating disulfide bonds (-S-S-) and gold nanoparticles (Au NPs) into the framework of the particles, we endowed the system with biodegradable properties and redox-responsive drug release behavior, resulting in biodegradable HMSNs (BHMSNs). Through optimization of shell thickness and composition, BHMSNs were obtained with an average diameter of 120 ± 5 nm and a shell thickness as low as 11.3 nm, exhibiting a high drug loading capacity (900.2 mg/g for DOX) and significant degradation efficiency. Embedding Au NPs into the biodegradable shell further enhanced their degradation performance. Under near-infrared (NIR) light irradiation, the drug delivery system demonstrated excellent photothermal conversion efficiency. Internalization behavior and cytotoxicity assays demonstrate that DOX-BHMSNs@Au can effectively deliver doxorubicin into cells and exhibit significantly enhanced antitumor activity under near-infrared light. This nanocarrier system possesses redox-responsive biodegradability and controlled drug release capabilities, which are promising for cancer therapy. Physical sciences/Materials science/Biomaterials/Biomedical materials Physical sciences/Materials science/Biomaterials/Drug delivery Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-6485418","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":456646987,"identity":"1afc2dcc-e7ff-42b0-b7a8-d7825fa53fe4","order_by":0,"name":"Huixia Zhang","email":"","orcid":"","institution":"China University of Mining and Technology","correspondingAuthor":false,"prefix":"","firstName":"Huixia","middleName":"","lastName":"Zhang","suffix":""},{"id":456646988,"identity":"a269770e-8a77-4867-9b2a-45befd06c299","order_by":1,"name":"Yan Zhang","email":"","orcid":"","institution":"China University of Mining and Technology","correspondingAuthor":false,"prefix":"","firstName":"Yan","middleName":"","lastName":"Zhang","suffix":""},{"id":456646989,"identity":"4a4ee15f-1557-4cc1-a6d2-ffaa564e9177","order_by":2,"name":"Zhencheng Diao","email":"","orcid":"","institution":"China University of Mining and Technology","correspondingAuthor":false,"prefix":"","firstName":"Zhencheng","middleName":"","lastName":"Diao","suffix":""},{"id":456646990,"identity":"d7acfb29-f484-4000-a24e-b1764616082e","order_by":3,"name":"Minmin Chen","email":"","orcid":"","institution":"Xuzhou Medical College","correspondingAuthor":false,"prefix":"","firstName":"Minmin","middleName":"","lastName":"Chen","suffix":""},{"id":456646991,"identity":"46da4ad7-5314-49e4-98db-07710d46db5b","order_by":4,"name":"Xichuan Cao","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA4UlEQVRIiWNgGAWjYDACZgY2GOsAlJFAtBY2kFIDIrQwwLXwGBCnxeA487PHPDV35Pnbez5+5s35w8DPnmPA8HMHbi2SzWzmxjzHnhnOOHN2szTvNgMGyZ43Boy9Z3Br4WfmYZPmYTucwHAjdxszSIvBjRwDZsY2PB4Ba/l3OEH+Rs4zsBZ7QlrAtvC2HU4AGs4GsUWCgBagX8wk5/YdNtx45pix5NxtxjwSZ54VHOzFo8Xg/OFnEm++HZaXO9788MPbbXJy/O3JGx/8xKMFA/CAiAMkaBgFo2AUjIJRgAUAABNTRxmuqzPmAAAAAElFTkSuQmCC","orcid":"","institution":"China University of Mining and Technology","correspondingAuthor":true,"prefix":"","firstName":"Xichuan","middleName":"","lastName":"Cao","suffix":""}],"badges":[],"createdAt":"2025-04-19 14:53:19","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-6485418/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-6485418/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":83436084,"identity":"1e189828-13a2-4174-9ba2-6f50231db50a","added_by":"auto","created_at":"2025-05-26 08:31:24","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":7026872,"visible":true,"origin":"","legend":"","description":"","filename":"ScientificReportsHollowmesoporoussilicananodeliverysystems.pdf","url":"https://assets-eu.researchsquare.com/files/rs-6485418/v1_covered_cf29aad5-b6d9-456f-83e5-aad5295860c6.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"Hollow mesoporous silica nano-delivery systems based on ultra-thin biodegradable shells a synergistic integration strategy for chemotherapy and photothermal therapy","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"","lastPublishedDoi":"10.21203/rs.3.rs-6485418/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-6485418/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"Mesoporous silica nanoparticles (MSNs) have been discovered to hold substantial potential in tumor treatment due to their ability to enhance drug tumor-targeting capacity and reduce side effects as a nanoparticle drug delivery system. We rationally designed and successfully synthesized hollow mesoporous silica nanoparticles (HMSNs) with a large cavity structure and ultra-thin shells. By incorporating disulfide bonds (-S-S-) and gold nanoparticles (Au NPs) into the framework of the particles, we endowed the system with biodegradable properties and redox-responsive drug release behavior, resulting in biodegradable HMSNs (BHMSNs). Through optimization of shell thickness and composition, BHMSNs were obtained with an average diameter of 120 ± 5 nm and a shell thickness as low as 11.3 nm, exhibiting a high drug loading capacity (900.2 mg/g for DOX) and significant degradation efficiency. Embedding Au NPs into the biodegradable shell further enhanced their degradation performance. Under near-infrared (NIR) light irradiation, the drug delivery system demonstrated excellent photothermal conversion efficiency. Internalization behavior and cytotoxicity assays demonstrate that DOX-BHMSNs@Au can effectively deliver doxorubicin into cells and exhibit significantly enhanced antitumor activity under near-infrared light. This nanocarrier system possesses redox-responsive biodegradability and controlled drug release capabilities, which are promising for cancer therapy.","manuscriptTitle":"Hollow mesoporous silica nano-delivery systems based on ultra-thin biodegradable shells a synergistic integration strategy for chemotherapy and photothermal therapy","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2025-05-16 17:48:43","doi":"10.21203/rs.3.rs-6485418/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"7e3bf2e0-d98d-4fe7-9411-051c41ecc7e5","owner":[],"postedDate":"May 16th, 2025","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[{"id":48536088,"name":"Physical sciences/Materials science/Biomaterials/Biomedical materials"},{"id":48536089,"name":"Physical sciences/Materials science/Biomaterials/Drug delivery"}],"tags":[],"updatedAt":"2025-05-26T08:23:16+00:00","versionOfRecord":[],"versionCreatedAt":"2025-05-16 17:48:43","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-6485418","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-6485418","identity":"rs-6485418","version":["v1"]},"buildId":"8U1c8b4HqxoKbykW_rLl7","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}