Mog-Specific T Cell Response Amplified in Para- and Post-Sar-Cov-2 Infection in Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease

We describe clinical characteristics and immunophenotypes in 2 patients with myelin-oligodendrocyte- glycoprotein (MOG)-antibody-associated-disease after COVID-19. The first case was a 74-year-old man who developed optic neuritis two days after COVID-19. Immunological assays revealed reduced absolute CD8+ T- and B-cell counts with increased frequency of NK cells. In a 63-year-old man with optic neuritis six months after COVID-19, a frequency of CD8+ T-cells was elevated with a relatively low fraction of naïve and a high fraction of effector memory CD8+ T-cells. Both patients had increased CD38+HLA-DR+ T-cells, SARS-CoV-2-specific and MOG-specific T-cell responses. Both patients recovered after high- dose steroids.