Effect of Human Chorionic Gonadotropin Injection before Frozen-Thawed Embryo Transfer

Abstract Purpose To investigate the effect of human chorionic gonadotropin (hCG) in hormone replacement regimen for frozen-thawed embryos Methods We performed a retrospective cohort study and included patients who underwent frozen embryo transfer (FET) between January 1, 2015, to May 31, 2021. According to the protocols for the FET cycle, the patients were divided into control (n = 238) and hCG groups (n = 216). The clinical pregnancy rate, live birth rate, early abortion rate, late abortion rate, and ectopic pregnancy rate were compared between the two groups. Results There was a significant difference in clinical pregnancy rate between the hCG and control groups (54.6 vs. 45.5%, p = 0.048). The ectopic pregnancy rate decreased (0.4% vs. 1.2%), while the live birth rate increased (35.6 vs. 28.6%, p = 0.107) in the hCG group; however, these differences were not statistically significant. Conclusion HCG injection in the hormone replacement regimen for FET increased the pregnancy rate.