The expression and significance of HIF-1 and COX-2 in uterine endometrium of anovulatory dysfunctional uterine bleeding

Objective:To investigate the relationship between HIF-1 and COX-2 by detecting their expression in anovulatory dysfunctional uterine bleeding(ADUB).Methods:70 cases of various proliferative endometrial samples of ADUB and 10 normal endometrial samples were chosen.All of the cases were obtained from the second affiliated hospital of HMU.The expression of HIF-1 and COX-2 was detected by using immunohistochemical staining with appropriate antibodies.Results:HIF-1 and COX-2 were positively expressed in the nucleus and plasm of glandular epithelial cells of the endometrium;The positive expression rates of HIF-1 in endometrium of normal and ADUB were respectively 10.00%(1/10) and 42.86%(30 /70),while COX-2 20.00%(2/10) and 67.14%(47/70).There was significant difference in the expression of HIF-1 and COX-2 between ADUB and normal proliferative endometrium(P0.05).There was no significant relationship between Livin and Bax.Conclusions:The expression of HIF-1 and COX-2 is potentized in ADUB.They maybe play roles during the development and progression of ADUB.HIF-1 may be have important function during the angiogenesis of ADUB.COX-2 is related to the inhibition of endometrial glandular cell apoptosis and angiogenesis.