Cholestasis is associated with a higher rate of complications in both medical and surgical necrotizing enterocolitis.

Abstract Objective: To evaluate the relationship between cholestasis and outcomes in medical and surgical necrotizing enterocolitis (NEC). Study Design: A retrospective analysis of prospectively collected data from 1472 infants with NEC [455 medical (mNEC) and 1017 surgical (sNEC)] from the Children’s Hospital Neonatal Database. Results: The prevalence of cholestasis was lower in mNEC versus sNEC (38.2% vs 70.1%, p<0.001). In both groups, cholestasis was associated with lower birth gestational age [mNEC: OR 0.79 (95% CI 0.68-0.92); sNEC: OR 0.86 (95%CI 0.79-0.95)] and increased days of parenteral nutrition [mNEC: OR 1.08 (95%CI 1.04-1.13); sNEC: OR 1.01 (95%CI 1.01-1.02)]. For both groups, the highest direct bilirubin was associated with the composite outcome mortality or length of stay >75th percentile [mNEC: OR 1.21 (95%CI 1.06-1.38); sNEC: OR 1.06 (95%CI 1.03-1.09)]. Conclusion: Cholestasis with both medical NEC and surgical NEC is associated with adverse patient outcomes including increased mortality or extreme length of stay.