Association of the combination of obstructive sleep apnea risk and sleep duration with ideal cardiovascular health metrics in patients undergoing hemodialysis

Background: The purpose of this study was to explore the separated and combined associations of OSA risk and sleep duration with ideal cardiovascular health metrics in HD patients. Methods: : 470 HD participants (average: 59.48±12.89 y, 281 men) were included in this study. Sleep duration was measured as self-reported average sleep time during the previous month. OSA risk was evaluated by using STOP-BANG questionnaire. Participants were divided the into three groups by the number of ideal CVH metrics: 0-2,3-4, and 5-7. Ordinal logistic regression was performed to model the associations of CVH metrics with sleep duration, OSA risk, and their combined effects by adjusting for certain covariates. Results: : After adjusting for covariates, short sleep duration (< 7h) (OR=0.53; 95% CI [ 0.30, 0.92]) and OSA risk (OR=0.58; 95% CI [0.32, 0.83]) were negative associated with better CVH (ideal vs. intermediate; intermediate vs. poor), respectively. For HD patients with both short sleep duration and OSA risk, the proportional odds of having better CVH were 72% lower (odds ratio 0.28 [95% CI 0.13, 0.60]). Conclusions: : Short sleep duration and OSA risk are separated and combined related to poor CVH in hemodialysis patients. Suitable interventions for sleep may minimize the risk of subsequent cardiovascular disease.