From biomarkers to the operating room: solutions that are changing routine practice

This issue focuses on the transition from traditional approaches to personalized, predictive, and preventive medicine, highlighting studies demonstrating the high diagnostic and prognostic value of new biomarkers (such as the sFlt-1/PlGF ratio, miRNA, and VEGF) for the early detection of preeclampsia, the risk of preterm birth, and endometriosis recurrence. Modern surgical tactics are considered, including organ-preserving hemostasis and innovative methods of perioperative analgesia that comply with enhanced recovery after surgery (ERAS) principles. Current data on nutritional support (omega-3 PUFAs), the prevention of thromboembolic complications, the role of micronutrients in fertility, and the impact of endocrine disruptors on reproductive health are analyzed. The review also includes case studies and historical aspects, which together form a holistic understanding of modern solutions transforming routine medical practice.

About the Authors A. D. MakatsariyaRussian Federation Alexander D. Makatsariya - MD, Dr Sci Med, Prof., Academician of RAS. Scopus Author ID: 57222220144. WoS ResearcherID: M-5660-2016. 8 bldg. 2, Trubetskaya Str., Moscow 119048 A. V. Vorobev Russian Federation Alexander V. Vorobev - MD, PhD. Scopus Author ID: 57191966265. WoS ResearcherID: F-8804-2017. 8 bldg. 2, Trubetskaya Str., Moscow 119048

1. Matveev M.O., Prokopenko E.I., Nikolskaya I.G., Fedosov A.A., Blinov D.V., Bitsadze V.O. Quantitating soluble fms-like tyrosine kinase-1 (sFlt-1) and placental growth factor (PlGF) biomarker levels along with sFlt-1/PlGF ratio in patients with extragenital diseases for diagnostics of early- and late-onset preeclampsia. [Issledovanie urovnej biomarkerov – rastvorimoj fms-podobnoj tirozinkinazy-1 (sFlt-1), placentarnogo faktora rosta (PlGF) i ih sootnosheniya sFlt-1/PlGF u pacientok s ekstragenital'nymi zabolevaniyami dlya diagnostiki rannej i pozdnej preeklampsii]. Obstetrics, Gynecology, and Reproduction. 2025;19(5):632–653. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2025.671. 2. Zhilnio E.Y., Salov I.A., Naumova I.V. Personalization of the relapse probability and prevention of post-surgery ovarian endometriosis. [Personalizaciya veroyatnosti recidiva i profilaktiki endometrioza yaichnikov posle operacii]. Obstetrics, Gynecology, and Reproduction. 2025;19(5):654–666. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2025.649. 3. Inoyatova N.M., Kayumova D.T. The effect of three pairs of uterine vessels ligation on uterine and ovarian blood supply in patients with pathological blood loss. [Vliyanie perevyazki trekh par matochnyh sosudov na krovosnabzhenie matki i yaichnikov u pacientok s patologicheskoj krovopoterej]. Obstetrics, Gynecology, and Reproduction. 2025;19(5):667–674. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2025.659. 4. Gromova O.A., Torshin I.Yu., Ilovaiskaya I.A., Gromov A.N. Comprehensive biochemical analysis of the omega-3 polyunsaturated fatty acid-based drug and biologically active additive composition for nutritional support of pregnancy. [Kompleksnyj biohimicheskij analiz sostava preparatov i biologicheski aktivnyh dobavok omega-3 polinenasyshchennyh zhirnyh kislot dlya nutricial'noj podderzhki beremennosti]. Obstetrics, Gynecology, and Reproduction. 2025;19(5):675–689. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2025.669. 5. Pachuliya O.V., Lazareva T.E., Khalenko V.V., Illarionov R.A., Vashukova E.S., Postnikova T.B., Maltseva A.R., Milyutina Yu.P., Kornushina E.A., Bespalova O.N., Glotov A.S. Early modeling of preterm birth risk using a biocollection of pregnancy samples created at different gestational stages according to the "longitudinal biobanking" strategy. [Rannee modelirovanie riska prezhdevremennyh rodov na platforme biokollekcii obrazcov beremennyh, sozdannoj na raznyh srokah gestacii soglasno strategii «longityudnoe biobankirovanie»]. Obstetrics, Gynecology, and Reproduction. 2025;19(5):691–704. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2025.686. 6. Stryuk R.I., Krikunova O.V., Lokshina E.E., Gomova T.A., Fedotova E.E. Efficacy and safety for preventing of venous thromboembolic complications in high-risk pregnant women: «BEREG» pregnancy registry results. [Effektivnost' i bezopasnost' profilaktiki venoznyh tromboembolicheskih oslozhnenij u beremennyh vysokogo riska: analiz rezul'tatov registra beremennyh «BEREG»]. Obstetrics, Gynecology, and Reproduction. 2025;19(5):705–715. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2025.652. 7. Kharlov N.S., Shapovalova E.A., Basos A.S., Karamyan R.A., Babina U.F., Belousov A.M. Superior hypogastric plexus block along with preemptive troacar site infiltration: a novel multimodal strategy for pain control following laparoscopic myomectomy. [Blokada verhnego gipogastral'nogo spleteniya v sochetanii s preventivnoj infil'tracionnoj anesteziej operacionnyh ran – novyj vzglyad na perioperacionnuyu anal'geziyu pri laparoskopicheskoj miomektomii]. Obstetrics, Gynecology, and Reproduction. 2025;19(5):717–726. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2025.682. 8. Gridasova O.S., Khizroeva J.Kh., Solopova A.G., Ivanov A.E., Blinov D.V., Tatarintseva A.Yu. Assessing blood vascular endothelial growth factor level in patients with vulvovaginal atrophy. [Ocenka urovnya faktora rosta endoteliya sosudov v krovi pacientok s vul'vovaginal'noj atrofiej]. Obstetrics, Gynecology, and Reproduction. 2025;19(5):727–736. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2025.684. 9. Gromova O.A., Torshin I.Yu., Tapilskaya N.I. Myoinositol and D-chiroinositol in combination with folates and manganese as factors of male health: effect on spermatozoa structure and fertility. [Mioinozitol i D-hiroinozitol v komplekse s folatami i margancem kak faktory muzhskogo zdorov'ya: vozdejstvie na strukturu i fertil'nost' spermatozoidov]. Obstetrics, Gynecology, and Reproduction. 2025;19(5):737–757. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2025.687. 10. Kolomytseva L.N., Nebora E.D., Dzhamalutinov A.D., Sufiyarov D.I., Muginova D.R., Mullagulova I.I., Tushigov A.S., Bazarova Z.D., Nosinkova T.A., Khuseynova L.A., Derevyanko K.A., Abaeva M.P., Magomedova Zh.Zh., Borlakova S.M. Ovarian toxicity of endocrine-disrupting chemicals: current state of the problem. [Ovarial'naya toksichnost' endokrinnyh dizraptorov: sovremennoe sostoyanie problem]. Obstetrics, Gynecology, and Reproduction. 2025;19(5):759–775. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2025.658. 11. Pavlova Z.Sh., Orlova I.A., Kamalov A.A. Progesterone influence on prostate diseases and prospects in preventing and treating benign prostatic hyperplasia. [Vliyanie progesterona na zabolevaniya predstatel'noj zhelezy i perspektivy ego ispol'zovaniya dlya profilaktiki i lecheniya dobrokachestvennoj giperplazii predstatel'noj zhelezy]. Obstetrics, Gynecology, and Reproduction. 2025;19(5):776–787. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2025.662. 12. Apolikhina I.A., Gorbunova E.A., Saidova A.S., Tarnaeva L.A. The role of local estriol therapy in comprehensive management of women with genitourinary menopausal syndrome: clinical observation series. [Rol' lokal'noj gormonal'noj terapii estriolom v kompleksnom vedenii zhenshchin s genitourinarnym menopauzal'nym sindromom: seriya klinicheskih nablyudenij]. Obstetrics, Gynecology, and Reproduction. 2025;19(5):788–799. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2025.668. 13. Karpova A.L., Mostovoi A.V., Baranov A.A., Anikeeva L.A., Klubnichkina E.V., Zaplatnikov A.L., Karpov L.N. Congenital human herpesvirus 6 infection in a full-term newborn: literature review and case report. [Vrozhdennaya infekciya u donoshennogo novorozhdennogo rebenka, vyzvannaya virusom gerpesa cheloveka 6-go tipa: obzor literatury i klinicheskij sluchaj]. Obstetrics, Gynecology, and Reproduction. 2025;19(5):801–811. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2025.635. 14. Kozlov L.A., Chikmareva K.A. Pedagogical thoughts on the term "Küstner–Chukalov's sign of placental separation". [Pedagogicheskie razdum'ya o termine «Priznak otdeleniya posleda Kyustnera–Chukalova»]. Obstetrics, Gynecology, and Reproduction. 2025;19(5):812–817. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2025.685. Review For citations: Makatsariya A.D., Vorobev A.V. From biomarkers to the operating room: solutions that are changing routine practice. Obstetrics, Gynecology and Reproduction. 2025;19(5):626-631. (In Russ.) https://doi.org/10.17749/2313-7347/ob.gyn.rep.2025.698 JATS XML This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.