Appendicular mucocele: two case reports and literature review

Gabriele Anania, Anania G, G Anania, Giaccari S, S Giaccari, G Solfrini, Solfrini G, L Scagliarini, Scagliarini L, Vedana L, L Vedana, G Resta, Resta G
Il Giornale di chirurgia · 2015 · vol. 36(6) , pp. 276–9 · doi:10.11138/gchir/2015.36.6.276 · PMID:26888705 · PMC4767376 · W2278752435
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⚙ AI-generated summary by claude@2026-06, 2026-06-13 ⓘ

This paper presents two case reports of appendicular mucocele treated with surgery and HIPEC, contributing to the literature on these controversial and difficult-to-diagnose mucinous appendiceal neoplasms.

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Abstract

The classification of mucinous tumors of the vermiform appendix is quite controversial, and includes a spectrum of neoplastic lesions ranging from benign proliferations, intraluminal, to invasive adenocarcinomas. Among the complications of appendicular mucinous neoplasms we should mention the "pseudomyxoma peritonei", a condition caused by cancerous cells (mucinous adenocarcinoma) that produce abundant mucin or gelationous ascites. Mucinous neoplasms of the appendix are rare diseases of unknown etiology. The diagnosis is difficult because of poorly specific clinical, biochemical and imaging parameters, and their detection can be occasional. Most of the reported cases involving women of reproductive age (with a history of endometriosis, abdominal surgery or pelvic inflammatory disease). The definitive diagnosis requires histology and immunohistochemistry. Cytoredutive surgery combined with hyperthermic intraperitoneal chemoterapy (HIPEC) is now considered the best treatment for this disease. We present two cases treated with surgery and HIPEC.

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Condition tags

endometriosis

MeSH descriptors

Appendix Cecal Diseases Cecal Diseases Cecal Diseases Mucocele Mucocele Mucocele Adult Female Humans Middle Aged

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