Uterorelaxing effects of vaginal progesterone: comparison of two methodologies for assessing uterine contraction frequency on ultrasound scans
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This study compared two ultrasound methods for measuring uterine contraction frequency to assess the uterorelaxing effects of vaginal progesterone.
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Abstract
ObjectiveTo assess the changes in uterine contractility induced by increasing doses of P administered to estrogenized women and to compare two methodologies for assessing uterine contraction frequency from ultrasound scans.DesignProspective double-blind parallel study.SettingAcademic tertiary center.Patient(s)Infertile women aged 21-39 years with premature ovarian failure.Intervention(s)P support set to duplicate the luteal phase was provided every 2 days by application of 1.125 g of Crinone 4% and 8% or 2.25 g of Crinone 8%, containing 45, 90, and 180 mg of P per application, respectively.Main outcome measure(s)Changes in uterine contraction frequency following exposure to three doses of vaginal P on ultrasound scans analyzed by visualizing accelerated image sequences and using a previously described three-dimensional (3D)-derived approach.Result(s)A decrease in uterine contraction frequency reached statistical significance on the third day of exposure to P without differences between the three dose groups. The two methods for measuring uterine contraction frequency on ultrasound scans were equivalent.Conclusion(s)At all three doses studied, the vaginal P gel Crinone administered to estrogenized women induced a profound decrease in uterine contraction frequency that duplicated the changes in contractility described in the luteal phase of the menstrual cycle. Analyzing uterine contraction frequency on accelerated image sequences is as effective as our more complex approach based on identifying contractions on time mode graphs electronically reconstructed using 3D-software.
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Cited by (8)
- Impairment of Uterine Contractility Is Associated with Unexplained Infertility 2020
- Uterine peristalsis and fertility: current knowledge and future perspectives: a review and meta-analysis 2017
- Altered uterine contractility in women with chronic endometritis 2015
- Pelvic Imaging in Reproductive Endocrinology 2013
- Pelvic Imaging in Reproductive Endocrinology 2009
- Control and function of uterine peristalsis during the human luteal phase 2006
- The Uterus and In Vitro Fertilization 2006
- 10.1016/s1047-9422(03)00013-0 2000
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