Primary peritoneal anaplastic giant cell carcinoma: case report of an unusual and highly malignant müllerian neoplasm.

Xian Long Lu, Cunxian Zhang, Fang Liu, Chih‐Wei Sung, Margaret M. Steinhoff, W. Dwayne Lawrence
In: Archives of pathology & laboratory medicine · 2008 · vol. 132(1) , pp. 109–12 · doi:10.5858/2008-132-109-ppagcc · PMID:18181661 · W1888002135
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This report describes a rare, highly malignant primary peritoneal anaplastic giant cell carcinoma with an aggressive clinical course in a 72-year-old woman.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-08 ⓘ

This case report describes a 72-year-old woman with lower abdominal pain whose CT showed diffuse omental thickening, and who underwent exploratory laparotomy with omentectomy, total hysterectomy, bilateral salpingo-oophorectomy, and appendectomy. Pathology showed extensive peritoneal tumor replacement in a distribution consistent with primary peritoneal carcinoma, but the neoplasm consisted almost entirely of diffusely infiltrative anaplastic giant cells rather than the usual papillary serous histology; immunohistochemistry supported carcinoma (AE1/AE3, CK7, WT-1, p53) and excluded lymphoma and choriocarcinoma, with the patient dying within 1 month despite cisplatin-based chemotherapy. The main limitation is that this is a single unusual case report, so clinicopathologic generalization and causality regarding prognosis are not established. This paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

Virtually all primary peritoneal carcinomas (PPCs) are of serous papillary type. We report an unusual histologic type of PPC composed of anaplastic giant cells, which exhibited an aggressive clinical course. A 72-year-old woman presented with lower abdominal pain. Computed tomography showed a diffuse omental thickening. The patient underwent an exploratory laparotomy with omentectomy, total hysterectomy, bilateral salpingo-oophorectomy, and appendectomy. Pathologic examination revealed extensive omental replacement by tumor but only superficial surface cortical involvement of both ovaries, a disease distribution consistent with a typical müllerian-derived PPC. However, this neoplasm was composed of diffuse anaplastic tumor giant cells, rather than serous carcinoma, which is the usual histologic type encountered in PPC. The patient died within 1 month after surgery. We report this unusual histologic variant of PPC to raise awareness that anaplastic giant cell carcinoma may arise in the pelvic peritoneum as a primary tumor.

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