Versatile and Ligand-Free Copper-Catalyzed α-Arylations of Aromatic Ketones Using Diaryliodonium Salts

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Abstract

A ligand and base free copper catalyzed synthetic methodology for the efficient alpha-arylation of aromatic ketones has been developed. The reaction of the ketone-derived silyl enol ethers with diaryliodonium salts led to the intermolecular C-C coupling displaying high functional group tolerance with a low catalyst loading.

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europepmc
last seen: 2026-05-19T01:45:01.086888+00:00