[Antibodies to cardiolipin and tumor-associated antigens CA-125 and CA-19-9 in patients with ovarian tumors]

Karpov NI; N I Karpov; Н. Ю. Карпов; Baranov AA; А. А. Баранов; A A Baranov; Е. Л. Насонов; E L Nasonov; Nasonov EL; Zakutskii AV; A V Zakutskii; N P Shilkina; Shilkina NP; Н П Шилкина; I I Barteneva; Юлия Юрьевна Бартенева; Barteneva II; O P Rechkina; Rechkina OP

[Antibodies to cardiolipin and tumor-associated antigens CA-125 and CA-19-9 in patients with ovarian tumors]

Karpov NI, N I Karpov, Н. Ю. Карпов, Baranov AA, А. А. Баранов, A A Baranov, Е. Л. Насонов, E L Nasonov, Nasonov EL, Zakutskii AV, A V Zakutskii, N P Shilkina, Shilkina NP, Н П Шилкина, I I Barteneva, Юлия Юрьевна Бартенева, Barteneva II, O P Rechkina, Rechkina OP

Klinicheskaia meditsina · 1996 · vol. 74(4) , pp. 42–5 · PMID:8999153 · W118012633

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This study found that antibodies to cardiolipin and tumor markers CA-125 and CA-19-9 are frequently elevated in ovarian tumors, particularly endometriosis, with parallel changes suggesting an autoimmune origin for ovarian endometriosis.

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Abstract

Antibodies to cardiolipin (ACL) were detected in 12 (35%) of 34 patients with tumors of the ovaries. 8 of 12 patients exhibited clinical signs of antiphospholipid syndrome, 9 (75%), 2 and 1 patients demonstrated isolated hyperproduction of IgG ACL, combined rise of IgG ACL and IgM ACL, IgM ACL, respectively. Most frequently ACL occurred in endometriosis of the ovaries and serous cystadenomas (50 and 60%, respectively). In 5 (42%) of 12 patients CA-125 antigen concentration was above the upper norm (35 U/ml), in 3 (25%) cases the level of CA 19-9 antigen was elevated. There were parallel changes of ACL concentration and tumor marker CA-125 before and after operation. Autoimmune origin of ovarian endometriosis is suggested.

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Condition tags

endometriosis

MeSH descriptors

Antibodies, Anticardiolipin Antibodies, Neoplasm CA-125 Antigen CA-19-9 Antigen Ovarian Neoplasms Adult Adult Aged Aged Antibodies, Anticardiolipin Antibodies, Anticardiolipin Antibodies, Neoplasm Antibodies, Neoplasm CA-125 Antigen CA-125 Antigen CA-19-9 Antigen CA-19-9 Antigen Female Female Humans

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