An Interesting Case of Sister Mary Joseph's Nodule Revealed by 18F-FDG PET

Oueriagli SN; Salah Nabih Oueriagli; Sahel OA; Omar Ait Sahel; Yassir Benameur; Benameur Y; Doudouh A; Abderrahim Doudouh

doi:10.4103/ijnm.ijnm_34_25

An Interesting Case of Sister Mary Joseph's Nodule Revealed by 18F-FDG PET

Oueriagli SN, Salah Nabih Oueriagli, Sahel OA, Omar Ait Sahel, Yassir Benameur, Benameur Y, Doudouh A, Abderrahim Doudouh

Indian journal of nuclear medicine : IJNM : the official journal of the Society of Nuclear Medicine, India · 2025 · vol. 40(4) , pp. 263–264 · doi:10.4103/ijnm.ijnm_34_25 · PMID:41064210 · PMC12503169

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A case report describes a 61-year-old woman with rectosigmoid adenocarcinoma presenting as a Sister Mary Joseph's nodule, identified via 18F-FDG PET/CT imaging alongside widespread metastases.

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This case report describes the diagnostic utility of 18F-FDG PET in identifying a Sister Mary Joseph’s nodule, which serves as a cutaneous metastasis from an underlying intra-abdominal malignancy. The authors detail the clinical presentation and imaging findings that led to the discovery of the primary cancer source through this specific radiological sign. No major limitations are explicitly stated beyond the inherent constraints of a single case study design. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

The Sister Mary Joseph's nodule is a rare umbilical metastatic lesion, occurring in 1%-3% of abdominopelvic adenocarcinomas. It represents the visible tip of the iceberg, and its presence is associated with a poor prognosis. We report the case of a 61-year-old postmenopausal female patient with rectosigmoid adenocarcinoma. An 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET) scan revealed, in addition to a large sigmoid mass, multiple hypermetabolic lumbo-aortic lymphadenopathies, secondary hypermetabolic pulmonary and hepatic nodules, and a large subcutaneous umbilical nodule consistent with a Sister Marie Joseph's nodule. This case supports the systematic use of 18F-FDG PET in oncologic evaluations involving suspicious umbilical nodules.

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Authorship

S. O. N. Design: S. O. N., O. A. S., Y. B., A. D., Data Collection or Processing: S. N. O., Analysis or Interpretation: S. N. O, A. D., Literature Search: S. N. O, O. A. S, Writing: S. N. O.

Declaration

The authors certify that they have obtained all appropriate patient consent forms. In the form, the patient has given her consent for her images and other clinical information to be reported in the journal. The patient understands that her name and initials will not be published and due efforts will be made to conceal identity, but anonymity cannot be guaranteed.

Coi Statement

There are no conflicts of interest.

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License: CC-BY-NC-SA-4.0