Observation on the Clinical Therapeutic Effect of Gonadotropin-Releasing Hormone Agonist on Endometriosis

Objective: To explore the clinical therapeutic effect of gonadotropin-releasing hormone agonist on endometriosis.Methods: 102 teachers of endometriosis treated in our clinic from August 2007 to January 2012 were randomly divided into three groups: 50 cases of gonadotropin-releasing hormone agonist(GnRH-a) plus reverse add treatment(group I),28 cases of GnRH-a withdrawal therapy(group II),24 cases as the control group(group III),the clinical efficacy,endocrinological changes of pituitary-ovary axis and adverse effects were compared among the three groups.Results: The total effective rate of the group I and II are 96.0 % and 85.7 % respectively,both are obviously higher than that of the group III(75.0 %,p0.05).The serum E2,FSH,LH,P level of patients from the group I and II after treatment were all significantly lower than before treatment(P 0.05),no significant difference of total effective rate and serum E2,FSH,LH,P level after treatment between the group I and II,had been found(P 0.05),in addition,no significant difference of bone density of the three groups before and after treatment was observed(P 0.05).Conclusion: Treatment with GnRH-a plus add-back or withdrawal therapy was able to improve the endocrine function of patients with endometriosis.The clinical efficacy was better than conventional therapy,and fewer adverse effects were observed,so it was worth being generalized in clinic.