Age-dependent blood signatures of rehabilitated patients with mild COVID-19

Growing evidence suggests that pulmonary and neurological sequelae from critical novel coronavirus disease 2019 (COVID-19) can occur which are closely related to immune responses. However, data on the long-term systemic biochemical sequelae in mild COVID-19 are lacking. Here we investigated the blood biochemical indexes and cytokines of 25 mild cases from Wuhan nine months after infection with COVID-19. Compared with control, rehabilitated patients with mild COVID-19 showed significant reduction in the levels of RBC count and ALB in an age-dependent manner. Major symptoms such as fatigue and memory decline were found in elderly rehabilitators. Besides the overall reduction in the correlations among hematologic indicators in rehabilitated patients, the serum cytokine assay also confirmed the age-related alterations such as the level of CD40 Ligand in rehabilitators with mild COVID-19. Our current data indicated the age-dependent long-term consequences after mild COVID-19 infection and continuous follow-up is warranted.