Innovative medical technology of succinic acid photophoresis in comorbid patients with adenomyosis

Ya. I. Uraeva, И. И. Иванова, Н. Н. Лазаренко
In: Fizioterapevt (Physiotherapist) · 2025 · pp. 107–115 · doi:10.33920/med-14-2502-13 · W4410312987
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-07-13 ⓘ

This study found that photophoresis of succinic acid combined with standard therapy reduced depression in women with adenomyosis, unlike standard therapy alone.

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⚙ AI-generated deep summary by claude@2026-07, 2026-07-13 · read from full text ⓘ

The paper proposes and studies an innovative intervention—succinic acid photophoresis (photoferesis) delivered as part of complex treatment—in comorbid women with stage II diffuse adenomyosis and chronic pelvic pain. Women of reproductive age with clinician- and lab-confirmed adenomyosis were enrolled, while key exclusions included allergic history or intolerance to study agents, acute disease stages, and general contraindications to physiotherapy; the aim was to assess the effect of this regimen on depression in these patients. A major caveat explicitly stated is that patients who did not want to participate or who violated protocol (e.g., missed procedures or used prohibited medications) were excluded, which could affect interpretability. This paper is centrally about adenomyosis — specifically, succinic acid photophoresis as part of treatment for stage II diffuse adenomyosis with chronic pelvic pain and associated somatized depression.

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Abstract

Objective. Adenomyosis, which is aggravated by the presence of chronic pelvic pain, in practice occurs against the background of the presence of other chronic diseases in patients, the combination of which can lead to a somatodepressive state in women. Relevance. To study the effect of complex treatment, including photophoresis of succinic acid, on the depressive state in women with diffuse adenomyosis stage II. Subject and methods. An open randomized and controlled study of women (n = 60) with diffuse adenomyosis stage II, aged 31.4 ± 8.6 years, was conducted. Patients were divided into two groups. Group 1 (control, n = 30) received standard drug therapy. Group 2 (main, n = 30) additionally received photophoresis of succinic acid. The effectiveness of the treatment was assessed using the Beck Depression Scale, as well as statistical analysis before treatment, after the course of treatment and after 6 months of observation. Results. Before treatment, patients in both groups, against the background of severe pain syndrome, showed significant differences in the signs of the BEC depression scale, compared with the norm. After the course of treatment and up to 6 months in the 2nd (main) group, the signs of the Beck Depression Scale began to decrease, which was accompanied by a pronounced therapeutic effect according to the g — Hedges criterion. In patients in the 1st (control) group, the studied signs of the Beck Depression Scale from the large therapeutic effect that occurred after the course of treatment decreased to baseline values by 6 months. Conclusion. Photophoresis of succinic acid, included in the complex treatment of patients with stage II adenomyosis in the 2nd (main) group reduced depression. In patients in the 1st (control) group who received only drug therapy, such therapeutic effectiveness was not observed.
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Заболевание эндометриозом проявляется срывом адаптационных реакций, развивающихся в виде «биопсихосоциального криза», который может изменить психическое состояние больных [1]. Нарушение работы организма при эндометриозе изменяет нейроэндокринный фон целостной системы организма. Это влечет за собой появление других заболеваний, которые утяжеляют основную патологию, но имея некоторые общие патогенетические черты на молекулярно-биологическом уровне. Общей чертой этих заболеваний может являться соматизированная депрессия [2, 3]. При лечении таких состояний используют лекарственные средства, зачастую из класса антидепрессантов и психотропных средств, которые могут неоднозначно влиять на организм больного при сочетании с другими лекарственными средствами [4]. С целью лечения больных с соматизированной депрессией эффективно используют физические факторы, такие как электросон, светотерапию, ванны различного состава [5–7]. Нами предлагается новая инновационная технология фотофореза янтарной кислоты (ЯК) у коморбидных больных с диффузным аденомиозом II стадии с хронической тазовой болью (далее АМ). Изучить влияние комплексного лечения, включающего фотофорез янтарной кислоты, на состояние депрессии у женщин с диффузным аденомиозом II стадии с хронической тазовой болью. Критерии включения в исследование: установленный диагноз АМ подтвержденный клинико-лабораторными и функциональными методами; наличие хронического тазового болевого синдрома; репродуктивный возраст;подписание информированного согласия пациенткой. Критерии невключения в исследование: возраст женщины моложе 20 лет и старше 42 лет, аллергические реакции в анамнезе или индивидуальная непереносимость используемых лекарственных средств, острая стадия любого заболевания, общие противопоказания к физиотерапии и частные — к янтарной кислоте и лазерной терапии. Критерии исключения из исследования: нежелание пациента участвовать в настоящем исследовании, несоблюдение пациентом правил участия в исследовании (пропуск процедур, самостоятельное применение препаратов, запрещенных в исследовании), появление причин в ходе исследования, угрожающих безопасности пациента, общие противопоказания к физиотерапии.

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adenomyosischronic_pelvic_pain

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